Experimental combo targets tough breast cancer
NCT ID NCT03901469
Summary
This study tested whether combining two drugs, ZEN003694 and talazoparib, could help control triple-negative breast cancer in patients whose cancer had progressed despite prior treatments. The trial involved 115 adults with advanced disease who had not responded to previous therapies, excluding those with specific genetic mutations. Researchers measured how well the combination shrank tumors, controlled disease progression, and affected patients' quality of life, while closely monitoring side effects.
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Contacts and locations
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Locations
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Affliated Hospital of Jining Medical University
Jining, Shandong, 272000, China
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Banner MD Anderson Cancer Center
Gilbert, Arizona, 85234, United States
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Dana Farber Cancer Institute
Boston, Massachusetts, 02115, United States
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Emory University Winship Cancer Institute
Atlanta, Georgia, 30322, United States
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Hunan Cancer Hospital
Changsha, Hunan, 410000, China
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Institut Jules Bordet
Anderlecht, 1070, Belgium
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MD Anderson
Houston, Texas, 77030, United States
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Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
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START Madrid
Madrid, 28050, Spain
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Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Guangzhou, Guangdong, 510289, China
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Sun Yat-sen University Cancer Center
Guangzhou, Guangdong, 510060, China
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Tennessee Oncology (Sarah Cannon)
Nashville, Tennessee, 37203, United States
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The First Affiliated Hosptial of Bengbu Medical College
Bengbu, Anhui, 233000, China
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The Second People's Hospital of Neijiang
Neijiang, Sichuan, 641100, China
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Tianjing Medical University Cancer Institute & Hospital
Tianjin, Tianjin Municipality, 300060, China
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UZ Leuven
Leuven, 3000, Belgium
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University of Kansas Cancer Center
Westwood, Kansas, 66203, United States
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University of Pennsylvania
Philadelphia, Pennsylvania, 19104, United States
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Vall d'Hebron Institute of Oncology (VHIO)
Barcelona, 08035, Spain
Conditions
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