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Fatty foods spark brain inflammation, study aims to find out why

NCT ID NCT07557628

Knowledge-focused Sponsor: Centre Hospitalier Universitaire Dijon Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how eating a high-fat meal affects a part of the brain called the hypothalamus, which controls hunger and metabolism. Researchers will use MRI scans and blood tests in 20 healthy men to see if the brain's immune cells become active after a fatty meal. The goal is to better understand the link between diet and brain function, which could help in fighting obesity.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could reveal how the brain's immune cells respond to fatty foods, potentially pointing to new ways to manage obesity and overeating.
What could go wrong
This is a very early, small study in only 20 healthy men, so results may not apply to women or people with health conditions. It is observational and does not test a treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 20 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

May 2026

An estimate. Start dates often move.

Expected to finish

May 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Healthy male volunteers

Ages

20 years and older

Sex

Male participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * A person who has given oral consent * Male * Body Mass Index (BMI) between 18.5 and 30 kg/m² * Age ≥ 20 years Exclusion Criteria: * A person subject to a measure of legal protection (guardianship, tutorship) * A person subject to a judicial protective measure * A person who is not enrolled in or eligible for a social security program * Subject does not speak French * Subjects with a pacemaker or any other contraindication to MRI * Subjects with type 1 or type 2 diabetes * Subjects with a chronic inflammatory condition * Subjects with a neuropsychiatric condition * Subjects taking anti-inflammatory medication or medication that affects the central nervous system * Known hypersensitivity to foods provided during the study

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pathophysiology

How to take part

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  1. The places running it

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  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Chu Dijon Bourgogne

    Dijon, 21000, France

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