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Scientists map hidden brain layers to unlock new treatments

NCT ID NCT07073391

Knowledge-focused Sponsor: Christopher I. Petkov Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how information moves through the six layers of the brain's cortex. Researchers will use advanced MRI and brain recordings in 100 neurosurgery patients and healthy volunteers during memory and language tasks. The goal is to understand this missing piece of brain function, which could lead to better diagnosis and treatment for brain disorders.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Sep 2032

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Candidate patient research participants are those requiring DBS implant, epilepsy/tumor/biopsy resection procedures that require awake treatment with craniotomy. The patients can participate in the intracranial recordings, brain imaging and tissue sampling parts of the research. Control healthy participants will only participate in the non-invasive brain imaging study with fMRI in 7 Tesla.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients: Eligible for wake DBS implantation or epilepsy/tumor/biopsy treatment procedure, within the age range of 18 and 80 years old. * Healthy controls: can only participate in the non-invasive brain imaging study, within the age range of 18 and 80 years old. Exclusion Criteria: * Psychiatric disorder * Drug addiction * Not able to conduct an English based language task * Not capable of being scanned with MRI (e.g., metal implants)

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Laminar circuits Neuronal mechanisms

How to take part

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  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

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