NIH launches study to map brain changes in kids with rare genetic disorders

NCT ID NCT01132885

Recruiting now Knowledge-focused Sponsor: National Institute of Mental Health (NIMH) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 05, 2026 · Updated 7 times

Summary

This study aims to understand how the brain develops in children with Williams syndrome or 7q11.23 duplication syndrome, compared to healthy children. Researchers will use MRI scans and cognitive tests to track changes over time. The goal is to learn how these genetic variations affect brain structure and function during childhood and adolescence.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could reveal how specific genetic changes affect brain development, pointing toward future therapies for related conditions.
What could go wrong: This is an observational study, not a treatment trial. It may not lead directly to any new therapies, and results may take years to translate into clinical practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

7q11.23 microduplication syndrome Williams syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DUPLICATION WILLIAMS SYNDROME

Contacts and locations

Locations

National Institutes of Health Clinical Center
RECRUITING

Bethesda, Maryland, 20892, United States

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