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First-in-Human trial tests 'Vaccine' to train immune system against deadly brain cancer

NCT ID NCT04808245

Ongoing Disease control Sponsor: German Cancer Research Center Source: ClinicalTrials.gov ↗

Summary

This early-stage trial is testing a new personalized vaccine designed to treat a specific, hard-to-treat brain tumor called H3-mutated glioma. The vaccine aims to teach the patient's own immune system to recognize and attack the cancer cells. It is being given alongside standard radiotherapy and an immunotherapy drug (atezolizumab) to 15 adult patients to first check for safety and to see if it triggers the desired immune response.

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Contacts and locations

Locations

  • Clinic and Polyclinic for Neurosurgery, University Hospital Carl Gustav Carus Dresden

    Dresden, Saxony, 1307, Germany

  • Clinical Neuro-Oncology Section, University Hospital Bonn (UKB)

    Bonn, North Rhine-Westphalia, 53127, Germany

  • Department of Neurology and Polyclinic, Universitiy Clinic Heidelberg

    Heidelberg, Baden-Wurttemberg, 69120, Germany

  • Department of Neurosurgery with Pediatric Neurosurgery

    Berlin, State of Berlin, 10117, Germany

  • Dr. Senckenberg Institute for Neurooncology, University Hospital Frankfurt

    Frankfurt am Main, Hesse, 60528, Germany

  • Neurooncology Department, University Hospital Essen

    Essen, North Rhine-Westphalia, 45147, Germany

  • University Clinic Tuebingen, Neurological Clinic, Department of Neurology

    Tübingen, Baden-Wurttemberg, 72076, Germany

  • University Medical Center Mannheim, Department of Neurology

    Mannheim, Baden-Wurttemberg, 68167, Germany

Conditions

Explore the condition pages connected to this study.

NEWLY DIAGNOSED H3-MUTATED GLIOMA