Can botox ease leg stiffness after stroke? new trial investigates
NCT ID NCT03992404
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a single injection of botulinum toxin (NT 201) can reduce leg muscle stiffness caused by stroke or traumatic brain injury in adults. About 600 participants will be randomly assigned to receive either the treatment or a placebo, and neither they nor their doctors will know which they got. The main goal is to see if the treatment improves muscle tightness and overall function better than no treatment.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Azienda Ospedaliera Universitaria Ospedali Riuniti Di Foggia; Merz Investigational Site #0390018
Foggia, 71122, Italy
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Brooks Rehabilitation Clinical Integration and Research, Merz investigational site #0010483
Jacksonville, Florida, 72204, United States
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CHU Brugmann Neurology; Merz investigational site #0320015
Brussels, 1020, Belgium
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CHU Lille/Hôpital Swynghedauw; investigational site # 0330045
Lille, 59000, France
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CRR, Mee Suva (Clinique romande de réadaptation), Merz investigational site #0410016
Sion, 1950, Switzerland
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Cambridge University Hospitals NHS Foundation Trust; Merz Investigational Site 0440023
Cambridge, CB2 0QQ, United Kingdom
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DKD HELIOS Medical Center, Fachbereich Neurologie, Merz Investigational Site #0490081
Wiesbaden, 65191, Germany
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Federal State Autonomous Institution "National Medical Research Centre "Treatment and Rehabilitation" of the Ministry of Health of the Russian Federation, Neurology department, Merz Investigational Site # 0070305
Moscow, 125367, Russia
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Federal State Budgetary Educational Institution of Higher Education "Krasnoyarsk State Medical University n.a. Professor V.F. Voino-Yasenetskiy of Ministry Healthcare of Russian Federation", Merz Investigational Site #0070306
Krasnoyarsk, 660049, Russia
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Federal State Budgetary Institution "National Medical Research Centre of Psychiatry and Neurology n.a. V.M. Bekhterev" of the Ministry of Healthcare of the Russian Federation, Merz Investigational Site #0070009
Saint Petersburg, 195119, Russia
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Filia 7 Centrum Kompleksowej Rehabilitacji Sp. z o.o., Merz Investigational Site #0480100
Warsaw, 01-518, Poland
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Glenrose Rehabilitation Hospital, Merz investigational site #0010195
Edmonton, T5G 0B7, Canada
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HFR Fribourg - Hôpital Cantonal, Department of Rehabilitation, Merz Investigational site #0410014
Meyriez, 3280, Switzerland
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Heinrich Heine University Duesseldorf, Department of Neurology; Merz Investigational Site #0490071
Düsseldorf, 40225, Germany
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Hospital Universitari Mútua de Terrassa, Merz Investigational Site #0340003
Terrassa, 08221, Spain
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Hospital Universitario Juan Ramón Jiménez, Merz Investigational Site #0340037
Huelva, 21005, Spain
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Hospital Universitario La Paz, Merz Investigational Site #0340007
Madrid, 28046, Spain
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Howard A. Rusk Rehabilitation Center; Merz investigational site #0010283
Columbia, Missouri, 65203, United States
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IRCCS Ospedale Policlinico S. Martino, U.O.Complessa Riabilitazione e Rieducazione Funzionale; Merz investigational site #0390020
Genova, 16132, Italy
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Icahn School of Medicine at Mount Sinai, Neurology Department, Merz Investigational Site #0010191
New York, New York, 10029, United States
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Indywidualna Praktyka Lekarska dr. hab. Med. Anna Szczepanska-Szerej, Merz Investigational Site #0480096
Lublin, 20-582, Poland
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Institut Universitaire de Readaptation Clemenceau, Physical Medicine / Rehabilitation Medecine, Merz Investigational site # 0330063
Strasbourg, 67000, France
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Institute of Neurology, Psychiatry and Narcology of NAMS of Ukraine, MC "Neuron", Merz Investigational Site #3800018
Kharkiv, 61000, Ukraine
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Institute of Neurology, Psychiatry and Narcology of NAMS of Ukraine; Merz Investigational Site #3800019
Kharkiv, 61000, Ukraine
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Instytut Psychiatrii i Neurologii, II Klinika Neurologiczna, Merz Investigational Site #0480023
Warsaw, 02-957, Poland
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Lviv regional clinical hospital; Merz investigational site # 3800020
Lviv, 79010, Ukraine
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Mazowiecki Szpital Brodnowski, Merz investigational site #0480064
Warsaw, 03-242, Poland
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Medical College of Wisconsin,Department of PM&R, Merz Investigational Site #0010237
Milwaukee, Wisconsin, 53226, United States
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NPE "Regional Clinical Centre of Neurosurgery and Neurology" Transcarpathian Regional Council; Merz investigational site #3800014
Uzhhorod, 88018, Ukraine
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NeuroKlinika Gabinet Lekarski Prof Andrzej Bogucki, Merz Investigational Site #0480101
Lodz, 90-640, Poland
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Neurologicka klinika, Fakultna nemocnica Trnava; Merz investigational site #4210009
Trnava, 917 01, Slovakia
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Neurologie Bewegt; Merz Investigational site #0490378
Berlin, 10627, Germany
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Neurologische Klinik und Poliklinik des Universitätsklinikums Würzburg, Merz Investigational Site #0490302
Würzburg, 97080, Germany
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Neurology Center of New England P.C., Merz investigative site #0010476
Foxborough, Massachusetts, 02035, United States
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Neurology and Physiotherapy Skopalikova, Merz Investigational Site #4200049
Brno, 61500, Czechia
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Neuryt Diagnostyka I Terapia Neurologiczna, Merz investigational site #0480106
Wroclaw, 50-305, Poland
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New England institute for clinical research; Merz Investigational Site #0010441
Stamford, Connecticut, 06905, United States
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Nova Clinical Research, Merz investigational site #0010474
Bradenton, Florida, 34209, United States
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Ospedale Alfredo Fiorini, UOSD Neurologia Universitaria; Merz Investigational site #0390022
Terracina, 04019, Italy
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Ospedale Maggiore della Carita, Dipartimento di Medicina fisica e Riabilitativa, Merz Investigational Site #0390017
Novara, 28100, Italy
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Pardubice Regional Hospital; Merz investigational site #4200025
Pardubice, 530 03, Czechia
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Petz Hospital, Neurology, Merz Investigational Site #0360010
Győr, 9024, Hungary
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Physical Medicine and Rehabilitation at University of Alabama at Birmingham; Merz investigational site #0010479
Birmingham, Alabama, 35233, United States
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Projekt Samodzielni Sp z o.o., Merz Investigational Site #0480099
Warsaw, 02-121, Poland
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Pôle Saint-Hélier; Merz investigational site #0330024
Rennes, 35000, France
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Rancho Research Institute at Rancho Los Amigos National Rehabilitation Center; Merz investigational site #0010184
Downey, California, 90242, United States
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Rangueil Hospital-University Hospital Center (CHU) of Toulouse, Médecine physique et de réadaptation, Merz investigational site #0330025
Toulouse, 31059, France
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Raymond Poincaré University Hospital, Service de MPR Pôle Handicap-Rééducation, Merz Investigational site #00330018
Garches, 92380, France
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Rivne City Hospital 2, Department of Clinical Neurology and Neurorehabilitation; Merz investigational site #3800016
Rivne, 33001, Ukraine
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Royal Devon and Exeter Foundation Trust Hospital, Department of Neurology, Merz Investigational Site #0440047
Exeter, EX2 5DW, United Kingdom
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Sarasota Memorial Health Care System, Rehabilitation Medicine, Merz investigational site #0010478
Sarasota, Florida, 34239, United States
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Specjalistyczna Praktyka Lekarska Dr. n. med Stanisław Ochudło, Merz Investigational Site #0480077
Katowice, 40-097, Poland
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Specjalistyczne Gabinety Sp z o.o., Merz Investigational Site #0480059
Krakow, 30-539, Poland
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St.Damjan Hospital, Kisvarda; Merz investigational site #0360019
Kisvárda, 4600, Hungary
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State Autonomous Institution of Healthcare of Moscow City "Moscow Scientific and Practical Centre of Medical Rehabilitation, Regenerative and Sports Medicine of Moscow City Healthcare Department", Merz Investigational Site #0070011
Moscow, 105005, Russia
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The Walton Centre NHS Foundation Trust; Neuroscience Research Centre; Merz Investigational site #0440004
Liverpool, L9 7LJ, United Kingdom
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UCL Bruxelles, Physical Medicine & Rehabilitation Department, Merz Investigational Site #0320013
Brussels, 1200, Belgium
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UCL Mont Godinne, Physical Medicine & Rehabilitation Department; Merz Investigational Site #0320008
Yvoir, 5530, Belgium
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UT Southwestern Medical Center, Department of Physical Medicine & Rehabilitation, Merz investigational site #0010082
Dallas, Texas, 75390-9055, United States
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UZ Leuven Pellenberg campus; Merz investigational site #0320014
Pellenberg, 3212, Belgium
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Uniklinik RWTH Aachen, Neurologie, Merz Investigational Site #0490191
Aachen, 52074, Germany
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University Hospital Bratislav, 2nd Dept. of Neurology, Merz Investigational Site # 4210005
Bratislava, 83305, Slovakia
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University Hospital Ostrava; Neurology Departement, Merz investigational site #4200024
Ostrava, 708 52, Czechia
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University Hospital of Bern, Center of Parkinson's diseases and Movement disorders (ZfPB), Merz investigational site #0410015
Bern, 3010, Switzerland
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University of Arkansas for Medical Sciences, Merz investigational site #0010481
Little Rock, Arkansas, 72205, United States
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University of Bonn Medical Center, Department of Neurodegenerative disease, Merz investigational site #0490390
Bonn, 53127, Germany
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University of Pittsburgh Medical Center, Physical Medicine & Rehabiliation, Merz Investigational Site #0010211
Pittsburgh, Pennsylvania, 15213, United States
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University of Szeged, Department of Neurology, Merz investigational site #0360008
Szeged, 6725, Hungary
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University of Texas Health Science Center McGovern, Medical School Department of PM&R; merz investigational site #0010183
Houston, Texas, 77030, United States
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Universitätsklinikum Hamburg-Eppendorf, Merz Investigational site #0490079
Hamburg, 20246, Germany
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Weill Cornell Medical Center, Department of Rehabilitation Medicine; Merz Investigational Site #0010440
New York, New York, 10065, United States