Can a Plant-Based pill tame your daily jitters?

NCT ID NCT07511088

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a botanical supplement can reduce feelings of stress or anxiety in healthy adults who experience these feelings at least once a week. Participants will take either the supplement or a placebo when they feel stressed and rate their anxiety over the next five hours. The goal is to see if the supplement provides real relief in everyday life.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
botanical extract supplement
What this could lead to
If it works, this could offer a natural, on-demand option for managing mild stress or anxiety without a prescription.
What could go wrong
This is an early-stage trial with subjective self-reported outcomes, so results may not be conclusive. The supplement may work no better than a placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 250 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2026

Expected to finish

Jun 2026

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Female and male subjects aged \>18 and \<60 years. 2. Self-reported experience of episodic stress or situational anxiety of ≥1 x per week. 3. Score of ≥ 40 on a self-assessment of typical anxiety on a Visual Analog Scale where 0 represents "not stressed or anxious" and 100 represents "extremely stressed or anxious." 4. Score of ≥ 20 on the Positive Reactivity component of the Perth Emotional Reactivity Scale- Short Form (PERS-S). 5. Ability to complete surveys on the Alethios digital platform. 6. Subject is only taking well-established, stable doses of prescription and non-prescription medications that are not indicated to treat anxiety disorder. 7. Subject is in generally good health as determined by a review of self-reported medical history and in the opinion of the Principal Investigator. 8. Women of child-bearing potential must agree to use a medically approved form of birth control during the study. Acceptable methods of birth control include hormonal - oral (pill), implantable, injectable (shot), ring, or transdermal (patch) contraceptives; mechanical - spermicide in conjunction with a barrier such as a diaphragm or condom; or an intra-uterine device (IUD. 9. Subject agrees to abstain from cannabis use for the duration of the study period 10. Subject agrees to maintain current dietary habits and abstain from using dietary supplements or herbal products thought to affect a sense of calming, including ashwagandha, L-theanine, or St. John's Wort, for the duration of the study period. 11. Individual is aware of the procedures and agrees to participate in the study. 12. Participant understands and is willing to sign an Informed eConsent in conformance with 21 CFR Part 50: "Protection of Human Participants." Exclusion Criteria: 1. Score of \> 9 on the Patient Health Questionnaire (PHQ-9) or any response \> 0 on question 9 of the PHQ-9. 2. Score \> 24 on the Hamilton Anxiety Scale (HAM-A). 3. History of severe psychiatric or medical conditions that would interfere with participation. 4. Use of \>14 alcoholic drinks per week. 5. Subject is a regular cannabis user, as defined as equal to or greater than 2 times per week over the prior 6 weeks. 6. Individuals with a history of drug abuse or dependence within the past 6 months. 7. Changes to medication treatment for any health condition within the prior 3 months. 8. Use of any prescription medication for anxiety. 9. Any diagnosis of a mental health condition in the prior 3 months. 10. Unstable medical conditions. 11. Known hypersensitivity to study product. 12. Participant is pregnant, planning to become pregnant, or breastfeeding. 13. Pregnant or lactating women or women of child-bearing potential unwilling to use a medically approved form of birth control. 14. Inability to comply with digital study requirements. 15. Participation in a clinical study within 30 days prior to randomization

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Situational anxiety are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Alethios (Virtual)

    RECRUITING

    San Francisco, California, 94117, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.