Can a botanical extract heal your skin barrier? new study investigates
NCT ID NCT07645339
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether a plant extract added to skincare creams can help repair the skin's natural barrier. Researchers will temporarily damage the skin of 35 healthy Chinese women aged 35-60 using tape strips, then apply creams with or without the extract for 14 days. They will measure how quickly the skin heals by checking redness, dryness, and moisture levels.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- botanical extract in a topical skincare formulation
- What this could lead to
- If it works, this could lead to a new skincare ingredient that helps repair dry or damaged skin more effectively.
- What could go wrong
- This is a small, early study on healthy volunteers, not patients. The extract may not work better than the placebo, and results may not apply to real-world skin conditions.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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35 people
The number who actually took part.
- Started
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Oct 2025
- Expected to finish
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Jul 2026
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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35 to 60 years
- Sex
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Female participants only
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Chinese women aged 35 to 60 years in good general health. 2. Self-reported dry skin type. 3. a hydration index \< 35 and a trans-epidermal water loss (TEWL) ≥ 6g.m-2.h-1 on both anterior sides of the forearms at screening. 4. Willingness to avoid excessive sun exposure and comply with all study procedures including tape stripping and biosampling. 5. Bilateral forearms clear of scars, wounds, or significant pigment spots. Exclusion Criteria: 1. Current pregnancy, breastfeeding, or planning to become pregnant. 2. Current smokers or history of smoking within the last 6 months (including e-cigarettes/nicotine products). 3. History of facial cosmetic procedures (fillers, lasers, implants, Botox, etc.). 4. Active systemic or localized skin diseases (acne, eczema, psoriasis, atopic dermatitis). 5. Allergies to cosmetics, personal care products, or their ingredients. 6. Excessive UV exposure or frequent sauna/water sports usage. 7. Use of antihistamines, antibiotics, corticosteroids, or NSAIDs within the relevant washout periods. 8. Participation in any other clinical trial within the past 30 days.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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L'OREAL
Shanghai, China