New experimental drug BMS-986500 enters first human trials for advanced cancers
NCT ID NCT06997029
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-stage trial is testing an experimental drug called BMS-986500 in people with advanced solid tumors or breast cancer that has not responded to prior treatments. The study will first test the drug alone, then in combination with other cancer drugs (palbociclib and fulvestrant) for breast cancer patients. The main goals are to check safety, find the right dose, and see how the body processes the drug. About 234 participants are being recruited.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
BMS-986500 (an experimental drug)
What this could lead to
If successful, this could point toward a new treatment option for advanced solid tumors and breast cancer that has stopped responding to other therapies.
What could go wrong
This is a very early Phase 1 trial focused on safety and dosing, not effectiveness. The drug may not work or could have serious side effects. Results may not apply to all patients.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Locations
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Dana-Farber Cancer Institute
RECRUITINGBoston, Massachusetts, 02215, United States
Contact Phone: •••-•••-••••
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Dartmouth-Hitchcock Medical Center
RECRUITINGLebanon, New Hampshire, 03756, United States
Contact Phone: •••-•••-••••
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Hoag Memorial Hospital Presbyterian
RECRUITINGNewport Beach, California, 92663, United States
Contact Phone: •••-•••-••••
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Kansai Medical University Hospital
RECRUITINGHirakata, Osaka, 573-1191, Japan
Contact Phone: •••-•••-••••
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Local Institution - 0008
NOT_YET_RECRUITINGAurora, Colorado, 80045, United States
Contact
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Local Institution - 0011
NOT_YET_RECRUITINGNew York, New York, 10016, United States
Contact
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Local Institution - 0025
NOT_YET_RECRUITINGCopenhagen, 2100, Denmark
Contact
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Marin Cancer Care
RECRUITINGGreenbrae, California, 94904, United States
Contact Phone: •••-•••-••••
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Memorial Sloan Kettering Cancer Center
RECRUITINGNew York, New York, 10065, United States
Contact Phone: •••-•••-••••
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Moores Cancer Center
RECRUITINGLa Jolla, California, 92093, United States
Contact Phone: •••-•••-••••
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NEXT Oncology
RECRUITINGSan Antonio, Texas, 78229, United States
Contact Phone: •••-•••-••••
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National Cancer Center Hospital
RECRUITINGChuo-ku, Tokyo, 104-0045, Japan
Contact Phone: •••-•••-••••
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National Cancer Center Hospital East
RECRUITINGKashiwa, Chiba, 277-8577, Japan
Contact Phone: •••-•••-••••
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Northwell Health-Cancer Institute
RECRUITINGNew Hyde Park, New York, 11042, United States
Contact
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Odense Universitetshospital
RECRUITINGOdense, Region Syddanmark, 5000, Denmark
Contact Phone: •••-•••-••••
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Providence St. Jude Medical Center
RECRUITINGFullerton, California, 92835, United States
Contact Phone: •••-•••-••••
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Roswell Park Cancer Institute
RECRUITINGBuffalo, New York, 14263, United States
Contact Phone: •••-•••-••••
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START Dallas Fort Worth
RECRUITINGFort Worth, Texas, 76104, United States
Contact Phone: •••-•••-••••
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The Cancer Institute Hospital of JFCR
RECRUITINGKoto-ku, Tokyo, 135-8550, Japan
Contact Phone: •••-•••-••••
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University of Alabama at Birmingham
RECRUITINGBirmingham, Alabama, 35294-3300, United States
Contact Phone: •••-•••-••••
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Washington University School of Medicine
RECRUITINGSt Louis, Missouri, 63110, United States
Contact