New Dual-Action CAR t therapy targets Hard-to-Treat myeloma
NCT ID NCT06153251
First seen Mar 30, 2026 · Last updated Apr 24, 2026 · Updated 8 times
Summary
This early-stage study tests a new treatment called BMS-986453 for people with multiple myeloma that has come back or stopped responding to other therapies. The treatment uses specially engineered immune cells (CAR T cells) that target two proteins on cancer cells to attack them. About 187 participants will receive the therapy to find the safest dose and see how well it works, while monitoring side effects.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Locations
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City of Hope Comprehensive Cancer Center
RECRUITINGDuarte, California, 91010, United States
Contact Phone: •••-•••-••••
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Clinica Universidad de Navarra
RECRUITINGPamplona, Navarre, 31008, Spain
Contact Phone: •••-•••-••••
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Colorado Blood Cancer Institute
RECRUITINGDenver, Colorado, 80218, United States
Contact Phone: •••-•••-••••
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Dana-Farber Cancer Institute
RECRUITINGBoston, Massachusetts, 02215, United States
Contact Phone: •••-•••-••••
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Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca
RECRUITINGSalamanca, 37007, Spain
Contact Phone: •••-•••-••••
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Hôpital Saint-Louis
RECRUITINGParis, 75010, France
Contact Phone: •••-•••-••••
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Icahn School of Medicine at Mount Sinai
RECRUITINGNew York, New York, 10029, United States
Contact Phone: •••-•••-••••
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Local Institution - 0008
NOT_YET_RECRUITINGNashville, Tennessee, 37203, United States
Contact
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Memorial Sloan Kettering Cancer Center
RECRUITINGNew York, New York, 10065, United States
Contact Phone: •••-•••-••••
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Moffitt Cancer Center
RECRUITINGTampa, Florida, 33612, United States
Contact Phone: •••-•••-••••
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Stanford University Medical Center
RECRUITINGStanford, California, 94305, United States
Contact Phone: •••-•••-••••
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Swedish Medical Center
RECRUITINGSeattle, Washington, 98104, United States
Contact Phone: •••-•••-••••
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Tennessee Oncology
RECRUITINGNashville, Tennessee, 37203, United States
Contact Phone: •••-•••-••••
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UCSF Helen Diller Medical Center at Parnassus Heights
RECRUITINGSan Francisco, California, 94143, United States
Contact Phone: •••-•••-••••
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Universitaetsklinikum Heidelberg
RECRUITINGHeidelberg, D-69120, Germany
Contact Phone: •••-•••-••••
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Universitaetsklinikum Koeln
RECRUITINGCologne, 50937, Germany
Contact Phone: •••-•••-••••
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Universitaetsklinikum Wuerzburg
RECRUITINGWürzburg, 97080, Germany
Contact Phone: •••-•••-••••
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University of Alabama at Birmingham
RECRUITINGBirmingham, Alabama, 35294, United States
Contact Phone: •••-•••-••••
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Yale Cancer Center
RECRUITINGNew Haven, Connecticut, 06520, United States
Contact Phone: •••-•••-••••
Conditions
Explore the condition pages connected to this study.