New hope for mastocytosis sufferers: BLU-263 trial targets stubborn symptoms

NCT ID NCT04910685

First seen Nov 03, 2025 · Last updated May 09, 2026 · Updated 32 times

Summary

This study tests a new drug called elenestinib (BLU-263) for people with indolent systemic mastocytosis whose symptoms are not well controlled by current treatments. About 534 adults will receive either the drug or a placebo alongside their usual symptom-relief medications. The goal is to see if BLU-263 can reduce overall symptom burden and improve daily life.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for SMOLDERING SYSTEMIC MASTOCYTOSIS are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • AOU Policlinico G.Rodolico - San Marco

    RECRUITING

    Catania, 95123, Italy

  • Brigham and Women's Hospital

    RECRUITING

    Boston, Massachusetts, 02115, United States

  • CHU Amiens-Picardie

    RECRUITING

    Amiens, 80000, France

  • CHU Grenoble

    RECRUITING

    Grenoble, 38043, France

  • CHU Tivoli

    RECRUITING

    La Louvière, 7100, Belgium

  • CHU Toulouse - Hopital Larrey

    RECRUITING

    Toulouse, France

  • CHU de Caen

    RECRUITING

    Caen, France

  • CHU de Limoges

    RECRUITING

    Limoges, 87042, France

  • CHU de Nantes

    RECRUITING

    Nantes, 44093, France

  • CHU de Poitiers

    RECRUITING

    Poitiers, 86000, France

  • CHUPorto, EPE - Hospital de Santo António

    RECRUITING

    Porto, 4099-001, Portugal

  • Cancer and Haematology Centre

    RECRUITING

    Oxford, OX3 7LE, United Kingdom

  • Centro Hospitalar Universitario Sao Joao, E.P.E.

    RECRUITING

    Porto, 4200-139, Portugal

  • Centro Hospitalar de Lisboa Central, E.P.E. - Hospital de Santo Antonio dos Capuchos

    RECRUITING

    Lisbon, 1169-050, Portugal

  • Charité - Universitätsmedizin Berlin Institute of Allergology

    RECRUITING

    Berlin, 12203, Germany

  • Columbia University Medical Center

    RECRUITING

    New York, New York, 10032, United States

  • Consultorios Medicos Dr. Doreski - Fundacion Respirar

    RECRUITING

    Buenos Aires, 1426, Argentina

  • David Geffen School of Medicine at UCLA

    RECRUITING

    Los Angeles, California, 90095, United States

  • Duke Asthma, Allergy and Airway Center

    RECRUITING

    Durham, North Carolina, 27705, United States

  • ErasmusMC

    RECRUITING

    Rotterdam, South Holland, 3015 GD, Netherlands

  • Fakultní nemocnice Královské Vinohrady, Hematologická klinika 3. LF UK v Praze a FNKV

    RECRUITING

    Prague, 100 34, Czechia

  • General Hospital of Thessaloniki "G. Papanikolaou"

    RECRUITING

    Thessaloniki, 57010, Greece

  • Guy's and St Thomas's NHS Foundation Trust

    RECRUITING

    London, SE1 7EH, United Kingdom

  • Hospital Universitario Ramon y Cajal

    RECRUITING

    Madrid, 28034, Spain

  • Hospital Universitario Vall d'Hebron

    RECRUITING

    Barcelona, Spain

  • Hospital Virgen del Valle - Instituto de Estudios de Mastocitosis de Castilla-La Mancha

    RECRUITING

    Toledo, 45071, Spain

  • Huntsman Cancer Institute, University of Utah

    RECRUITING

    Salt Lake City, Utah, 84112, United States

  • Hôpital Necker - Départementd 'HématologieA dultes

    RECRUITING

    Paris, 75015, France

  • Hôpital de la Pitié Salpétrière

    RECRUITING

    Paris, 75013, France

  • Kepler Universitatsklinikum, Med Campus III. Clinic of Internal Medicine 3 - Hematology and Oncology

    RECRUITING

    Linz, 4021, Austria

  • LMU Klinikum

    RECRUITING

    Munich, 80377, Germany

  • Luzerner Kantonsspital

    RECRUITING

    Lucerne, 6000, Switzerland

  • Mayo Clinic

    RECRUITING

    Rochester, Minnesota, 55902, United States

  • Michigan Medicine University of Michigan

    RECRUITING

    Ann Arbor, Michigan, 48109, United States

  • Oslo University Hospital

    RECRUITING

    Oslo, N-0424, Norway

  • Princess Alexandra Hospital

    RECRUITING

    Woolloongabba, Queensland, Australia

  • Roswell Park Cancer Institute

    RECRUITING

    Buffalo, New York, 14263, United States

  • S.C. Ematologia Fondazione I.R.C.C.S. Policlinico San Matteo

    RECRUITING

    Pavia, 27100, Italy

  • S.S.D. Immunologia Clinica e Allergologia Azienda Ospedaliera Universitaria San Giovanni di Dio e Ruggi d'Aragona

    RECRUITING

    Salerno, 84131, Italy

  • SOD Ematologia (Ambulatori)- AOUC Azienda Ospedaliero Universitaria Careggi

    RECRUITING

    Florence, Tuscany, 50134, Italy

  • Stanford Cancer Institute

    RECRUITING

    Palo Alto, California, 94305, United States

  • The Alfred Hospital

    RECRUITING

    Melbourne, Victoria, 3004, Australia

  • The University of Texas, MD Anderson Cancer Center

    RECRUITING

    Houston, Texas, 77030, United States

  • UCHealth Blood Disorders and Cell Therapies Center - Anschutz Medical Campus

    RECRUITING

    Aurora, Colorado, 80045, United States

  • UOC Ematologia

    RECRUITING

    Milan, Lombardy, 20122, Italy

  • Unita Operativa di Ematologia AOU Policlinico S. Orsola-Malpighi

    RECRUITING

    Bologna, 40138, Italy

  • Unitversitair Ziekenhuis Antwerpen

    RECRUITING

    Edegem, Antwerpen, Belgium

  • Unità Operativa di Allergologia Azienda Ospedaliera Universitaria Integrata di Verona

    RECRUITING

    Verona, 37126, Italy

  • University Clinic Erlangen

    RECRUITING

    Erlangen, 91054, Germany

  • University Clinic Hamburg Eppendorf

    RECRUITING

    Hamburg, 20246, Germany

  • University College London Hospitals (UCLH), Haematology Cancer Clinical Trials Unit

    RECRUITING

    London, NW1 2PG, United Kingdom

  • University General Hospital - General Hospital of West Attica

    RECRUITING

    Chaïdári, 12462, Greece

  • University Hospital Basel

    RECRUITING

    Basel, C-4031, Switzerland

  • University Hospital Plymouth NHS Trust

    RECRUITING

    Plymouth, PL6 8DH, United Kingdom

  • University Hospital of Wales

    RECRUITING

    Cardiff, Wales, CF14 4XW, United Kingdom

  • University Hospital of Wales

    RECRUITING

    Cardiff, CF14 4XW, United Kingdom

  • University Medical Center Groningen

    RECRUITING

    Groningen, 9713 GZ, Netherlands

  • University of Alabama at Birmingham

    RECRUITING

    Birmingham, Alabama, 35294, United States

  • University of Cincinnati Medical Center

    RECRUITING

    Cincinnati, Ohio, 45219, United States

  • Universitätsklinikum RWTH Aachen Klinik für Hämatologie, Onkologie, Hämostaseologie und Stammzelltransplantation

    RECRUITING

    Aachen, Germany

  • Universitätsmedizin Mannheim III. Medizinische Klinik Universität Heidelberg Medizinische Fakultät Mannheim

    RECRUITING

    Mannheim, 68167, Germany

  • Uniwersyteckie Centrum Kliniczne Klinika Alergologii

    RECRUITING

    Gdansk, 80-214, Poland

  • Uppsala University Hospital

    RECRUITING

    Uppsala, 751 85, Sweden

  • Winship Cancer Institute, Emory University

    RECRUITING

    Atlanta, Georgia, 30322, United States

Conditions

Explore the condition pages connected to this study.