Sound waves open brain's shield to attack deadly tumor

NCT ID NCT04417088

First seen Jan 22, 2026 · Last updated Jun 16, 2026 · Updated 29 times

Summary

This early-phase study tested whether a special ultrasound device can safely open the blood-brain barrier in people with recurrent glioblastoma, a serious brain cancer. The goal was to let the chemotherapy drug carboplatin reach the tumor more effectively. Twenty-eight participants were enrolled to check safety and see if the barrier opening worked on MRI scans.

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Contacts and locations

Locations

  • Brigham and Women's Hospital

    Boston, Massachusetts, 02115, United States

  • Cleveland Clinic

    Cleveland, Ohio, 44195, United States

  • Stanford University

    Palo Alto, California, 94304, United States

  • University of Maryland

    Baltimore, Maryland, 21201, United States

Conditions

Explore the condition pages connected to this study.