Mushroom extract BLEX 404 joins chemo in new lung cancer trial
NCT ID NCT05764928
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This early-phase trial tests whether adding BLEX 404, a liquid extract from maitake mushrooms, to standard chemotherapy (pemetrexed + cisplatin) can help people with advanced non-small cell lung cancer that has no EGFR mutation. The study will enroll 32 adults aged 20–70 who have not had prior treatment. Researchers will first find the safest dose, then check if the combination shrinks tumors. The mushroom extract is thought to boost the immune system, but this is still experimental.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
BLEX 404 (a mushroom extract from maitake) combined with pemetrexed and cisplatin chemotherapy
What this could lead to
If it works, this could point toward a new combination therapy that boosts the immune system to better fight lung cancer.
What could go wrong
This is an early phase 1/2 trial with only 32 people, so it's too soon to know if it's safe or effective. The mushroom extract may not add benefit over standard chemo and could cause side effects.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Taipei Veteran General Hospital
Taipei, Taiwan
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