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Major trial aims to boost bladder cancer survival with new drug combo

NCT ID NCT03661320

Ongoing Disease control Sponsor: Bristol-Myers Squibb Source: ClinicalTrials.gov ↗

Summary

This large, late-stage study is testing whether adding immunotherapy drugs (nivolumab with or without BMS-986205) to standard chemotherapy before bladder removal surgery, and continuing them afterward, works better than chemotherapy alone. It involves 855 adults with muscle-invasive bladder cancer who haven't had prior treatment and are scheduled for surgery. The main goals are to see if the combination leads to more patients having no detectable cancer at surgery and extends the time patients live without their cancer returning.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Local Institution

    Saint Petersburg, 194044, Russia

  • Local Institution

    Saint Petersburg, 197758, Russia

  • Local Institution - 0001

    Omaha, Nebraska, 68198-6840, United States

  • Local Institution - 0002

    Strasbourg, 67091, France

  • Local Institution - 0003

    Toulouse, 31059, France

  • Local Institution - 0004

    Tampa, Florida, 33612, United States

  • Local Institution - 0005

    Chicago, Illinois, 60637, United States

  • Local Institution - 0006

    Peoria, Illinois, 61615, United States

  • Local Institution - 0007

    Nashville, Tennessee, 37232, United States

  • Local Institution - 0009

    Boston, Massachusetts, 02114, United States

  • Local Institution - 0010

    Jena, 07747, Germany

  • Local Institution - 0011

    Linz, 4020, Austria

  • Local Institution - 0012

    Vienna, 1090, Austria

  • Local Institution - 0013

    Herne, 44625, Germany

  • Local Institution - 0015

    Erfurt, 99028, Germany

  • Local Institution - 0016

    Nuremberg, 90419, Germany

  • Local Institution - 0020

    Pierre Benite Cedax, 69495, France

  • Local Institution - 0021

    Littleton, Colorado, 80120-4413, United States

  • Local Institution - 0022

    Tucson, Arizona, 85711, United States

  • Local Institution - 0023

    Norfolk, Virginia, 23502, United States

  • Local Institution - 0024

    Las Vegas, Nevada, 89169, United States

  • Local Institution - 0025

    Minneapolis, Minnesota, 55404, United States

  • Local Institution - 0028

    Tigard, Oregon, 97223, United States

  • Local Institution - 0029

    Albany, New York, 12208, United States

  • Local Institution - 0030

    Austin, Texas, 78731, United States

  • Local Institution - 0031

    Larissa, Thessalía, 411 10, Greece

  • Local Institution - 0032

    Milan, 20133, Italy

  • Local Institution - 0033

    Padua, 35128, Italy

  • Local Institution - 0034

    Pisa, 56126, Italy

  • Local Institution - 0035

    Roma, 00168, Italy

  • Local Institution - 0036

    Pensacola, Florida, 32503, United States

  • Local Institution - 0037

    Heidelberg, Victoria, 3084, Australia

  • Local Institution - 0038

    Murdoch, Western Australia, 6150, Australia

  • Local Institution - 0043

    St Leonards, New South Wales, 2065, Australia

  • Local Institution - 0047

    New York, New York, 10065, United States

  • Local Institution - 0049

    Ciudad Autónoma de Buenos Aires, Buenos Aires, 1280, Argentina

  • Local Institution - 0051

    Capital Federal, Buenos Aires, 1426, Argentina

  • Local Institution - 0052

    Santiago, Santiago Metropolitan, 8380456, Chile

  • Local Institution - 0053

    Santiago, Santiago Metropolitan, 8330024, Chile

  • Local Institution - 0054

    Santiago, Santiago Metropolitan, Chile

  • Local Institution - 0056

    Monterrey, Nuevo León, 64460, Mexico

  • Local Institution - 0058

    Sector 2, 022328, Romania

  • Local Institution - 0060

    Brussels, 1200, Belgium

  • Local Institution - 0062

    Wilrijk, 2610, Belgium

  • Local Institution - 0063

    Ghent, 9000, Belgium

  • Local Institution - 0064

    Bari, 70124, Italy

  • Local Institution - 0065

    Modena, 41012, Italy

  • Local Institution - 0066

    Haifa, 3109601, Israel

  • Local Institution - 0067

    Ramat Gan, 52621, Israel

  • Local Institution - 0068

    Beersheba, 84101, Israel

  • Local Institution - 0069

    Lake Success, New York, 11042, United States

  • Local Institution - 0070

    Amsterdam, 1066 CX, Netherlands

  • Local Institution - 0072

    Groningen, 9713 GZ, Netherlands

  • Local Institution - 0073

    Sittard-Geleen, 6162 BG, Netherlands

  • Local Institution - 0074

    Nice, 06189, France

  • Local Institution - 0075

    Marseille, 13273, France

  • Local Institution - 0076

    Craiova, 200542, Romania

  • Local Institution - 0078

    Aachen, 52074, Germany

  • Local Institution - 0079

    Magdeburg, 39120, Germany

  • Local Institution - 0080

    Göttingen, 37075, Germany

  • Local Institution - 0081

    Essen, 45136, Germany

  • Local Institution - 0082

    München, 81675, Germany

  • Local Institution - 0084

    Lübeck, 23538, Germany

  • Local Institution - 0085

    Trier, 54292, Germany

  • Local Institution - 0086

    Frankfurt am Main, 60590, Germany

  • Local Institution - 0087

    Auckland, 1023, New Zealand

  • Local Institution - 0089

    Christchurch, 8011, New Zealand

  • Local Institution - 0090

    Klagenfurt, 9020, Austria

  • Local Institution - 0091

    Krems, 3500, Austria

  • Local Institution - 0092

    Ijuí, Rio Grande do Sul, 98700-000, Brazil

  • Local Institution - 0093

    São José do Rio Preto, São Paulo, 15090-000, Brazil

  • Local Institution - 0094

    Fortaleza, Ceará, 60130-241, Brazil

  • Local Institution - 0095

    Jaú, São Paulo, 17210-080, Brazil

  • Local Institution - 0097

    Porto Alegre, Rio Grande do Sul, 90610000, Brazil

  • Local Institution - 0098

    Barretos, São Paulo, 14780-070, Brazil

  • Local Institution - 0099

    Ipatinga, Minas Gerais, 35160-158, Brazil

  • Local Institution - 0100

    Mainz, Rhineland-Palatinate, 55131, Germany

  • Local Institution - 0101

    Besançon, 25000, France

  • Local Institution - 0102

    Zapopan, Jalisco, 45050, Mexico

  • Local Institution - 0103

    Montería, 230003, Colombia

  • Local Institution - 0104

    Bucaramanga, 681004, Colombia

  • Local Institution - 0105

    Colima, 28017, Mexico

  • Local Institution - 0109

    Seville, 41013, Spain

  • Local Institution - 0111

    Madrid, 28007, Spain

  • Local Institution - 0112

    Madrid, 28033, Spain

  • Local Institution - 0113

    Lugo, 27003, Spain

  • Local Institution - 0114

    Madrid, 28041, Spain

  • Local Institution - 0117

    Lancaster, LA1 4RP, United Kingdom

  • Local Institution - 0121

    London, SE1 9RT, United Kingdom

  • Local Institution - 0122

    Glasgow, G12 0YN, United Kingdom

  • Local Institution - 0124

    Oxford, OX3 7LE, United Kingdom

  • Local Institution - 0127

    York, Yorkshire, YO31 8HE, United Kingdom

  • Local Institution - 0128

    Chelmsford, Essex, CM1 7ET, United Kingdom

  • Local Institution - 0129

    Minneapolis, Minnesota, 55455, United States

  • Local Institution - 0130

    Kingswood, New South Wales, 2747, Australia

  • Local Institution - 0131

    Garran, Australian Capital Territory, 2605, Australia

  • Local Institution - 0132

    Lorenskog, 1478, Norway

  • Local Institution - 0133

    Oslo, 0379, Norway

  • Local Institution - 0135

    Kaohsiung City, 833401, Taiwan

  • Local Institution - 0136

    Seoul, 03080, South Korea

  • Local Institution - 0137

    Goyang-si, Gyeonggi-do, 10408, South Korea

  • Local Institution - 0138

    Seoul, 06351, South Korea

  • Local Institution - 0139

    Taipei, 11217, Taiwan

  • Local Institution - 0140

    Seoul, 02841, South Korea

  • Local Institution - 0141

    Taipei, 100229, Taiwan

  • Local Institution - 0143

    North Adelaide, South Australia, 5006, Australia

  • Local Institution - 0144

    Atlanta, Georgia, 30342, United States

  • Local Institution - 0145

    Tampere, 33521, Finland

  • Local Institution - 0146

    Turku, 20251, Finland

  • Local Institution - 0148

    Helsinki, 00029, Finland

  • Local Institution - 0151

    Ciudad Autonoma Buenos Aires, Distrito Federal, 1118, Argentina

  • Local Institution - 0152

    Porto, 4200-072, Portugal

  • Local Institution - 0153

    Lisbon, 1649-035, Portugal

  • Local Institution - 0154

    Singapore, 168583, Singapore

  • Local Institution - 0156

    Málaga, 29010, Spain

  • Local Institution - 0157

    Macquarie University, New South Wales, 2109, Australia

  • Local Institution - 0158

    Grålum, 1714, Norway

  • Local Institution - 0159

    Kelowna, British Columbia, V1Y 5L3, Canada

  • Local Institution - 0160

    La Paz, BAJA Californa SUR, 23040, Mexico

  • Local Institution - 0163

    Paris, 75014, France

  • Local Institution - 0164

    Rio de Janeiro, 20231-050, Brazil

  • Local Institution - 0165

    Taichung, 407219, Taiwan

  • Local Institution - 0166

    Boston, Massachusetts, 02215, United States

  • Local Institution - 0168

    Niigata, Niigata, 9518520, Japan

  • Local Institution - 0169

    Yokohama, Kanagawa, 222-0036, Japan

  • Local Institution - 0170

    Hamamatasu, Shizuoka, 431-3192, Japan

  • Local Institution - 0171

    Kita-gun, Kagawa-ken, 761-0793, Japan

  • Local Institution - 0172

    Shinjuku-ku, Tokyo, 160-8582, Japan

  • Local Institution - 0173

    Sayama, Osaka, 589-8511, Japan

  • Local Institution - 0174

    Fukuoka, 812-8582, Japan

  • Local Institution - 0175

    Takatsuki, Osaka, 569-8686, Japan

  • Local Institution - 0176

    Hidaka-shi, Saitama, 3501298, Japan

  • Local Institution - 0177

    Sapporo, Hokkaido, 060-8543, Japan

  • Local Institution - 0178

    Minato-ku, Tokyo, 1058470, Japan

  • Local Institution - 0179

    Tsukuba, Ibaraki, 3058576, Japan

  • Local Institution - 0180

    Kyoto, 606-8507, Japan

  • Local Institution - 0181

    Columbia, Maryland, 21044, United States

  • Local Institution - 0182

    North York, Ontario, M2K 1E1, Canada

  • Local Institution - 0183

    Omaha, Nebraska, 68130, United States

  • Local Institution - 0184

    Sapporo, Hokkaido, 0030804, Japan

  • Local Institution - 0185

    Sapporo, Hokkaido, 0608604, Japan

  • Local Institution - 0186

    Komaki, Aichi-ken, 485-8520, Japan

  • Local Institution - 0188

    Saint-Herblain, 44805, France

  • Local Institution - 0189

    Charleston, South Carolina, 29425, United States

  • Local Institution - 0190

    Montreal, Quebec, H3T 1M5, Canada

  • Local Institution - 0191

    Cleveland, Ohio, 44195, United States

  • Local Institution - 0192

    Chicoutimi, Quebec, G7H 5H6, Canada

  • Local Institution - 0193

    Meldola (FC), 47014, Italy

  • Local Institution - 0194

    Chaïdári, 12462, Greece

  • Local Institution - 0195

    Athens, Attikí, 155 62, Greece

  • Local Institution - 0196

    Tel Aviv, Tel Aviv, 6423906, Israel

  • Local Institution - 0198

    Angers, 49100, France

  • Local Institution - 0199

    Clermont-Ferrand, 63000, France

  • Local Institution - 0200

    Montpellier, 34298, France

  • Local Institution - 0201

    Colombia, Bogota D.C., 0, Colombia

  • Local Institution - 0202

    Brest, Finistère, 29609, France

  • Local Institution - 0203

    Seongnam-si, Kyǒnggi-do, 13620, South Korea

  • Local Institution - 0204

    Créteil, Val-de-Marne, 94010, France

  • Local Institution - 0205

    Amiens, 80054, France

  • Local Institution - 0206

    La Tronche, 38043, France

  • Local Institution - 0208

    Gyeongsangnam-do, 50612, South Korea

  • Local Institution - 0209

    Boston, Massachusetts, 02215, United States

  • Local Institution - 0210

    Santiago, Santiago Metropolitan, 8420383, Chile

  • Local Institution - 0211

    Seoul, 05505, South Korea

  • Local Institution - 0212

    Porto Alegre, Rio Grande do Sul, 90035-001, Brazil

  • Local Institution - 0214

    São Paulo, 01221-020, Brazil

  • Local Institution - 0215

    Seongnam-si, 13496, South Korea

  • Local Institution - 0217

    Bordeaux, 33076, France

  • Local Institution - 0218

    Daegu, 41404, South Korea

  • Local Institution - 0219

    Cluj-Napoca, 400015, Romania

  • Local Institution - 0220

    Busan, 48108, South Korea

  • UC Davis Comprehensive Cancer Center

    Sacramento, California, 95817, United States

Conditions

Explore the condition pages connected to this study.

MUSCLE INVASIVE BLADDER CANCER URINARY BLADDER NEOPLASMS