New hope for bladder cancer patients who can't take chemo: study tests drug combos before surgery

NCT ID NCT04586244

First seen Nov 01, 2025 · Last updated May 16, 2026 · Updated 21 times

Summary

This study tested several drug combinations given before bladder removal surgery for people with muscle-invasive bladder cancer who could not take the standard chemotherapy drug cisplatin. The goal was to see if these treatments could boost immune cells in the tumor. The study was stopped early, so results are limited, but it aimed to find better options for this hard-to-treat group.

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Contacts and locations

Locations

  • Azienda Ospedaliera Universitaria Integrata Verona (Ospedale Borgo Roma)

    Verona, 37124, Italy

  • Hopital Europeen Georges Pompidou (Hegp)

    Paris, 75015, France

  • Hospital Saint Louis

    Paris, 75475, France

  • Institut Gustave Roussy

    Villejuif, 94805, France

  • Istituto Di Ricovero E Cura A Carattere Scientifico (Irccs) Ospedale San Raffaele

    Milan, 20132, Italy

  • Istituto Tumori Giovanni Paolo Ii Irccs Ospedale Oncologico Bari

    Bari, 70124, Italy

  • L Azienda Ospedaliero-Universitaria Di Bologna Policlinico S. Orsola - Malpighi

    Bologna, 40138, Italy

  • Ohio State University Medical Center Division of H

    Columbus, Ohio, 43210, United States

  • Oregon Health & Science University

    Portland, Oregon, 97239-4501, United States

  • Universita Campus Bio Medico Di Roma

    Roma, 00128, Italy

  • University of Cincinnati

    Cincinnati, Ohio, 45267, United States

  • University of Iowa

    Iowa City, Iowa, 52242, United States

Conditions

Explore the condition pages connected to this study.