Race against time: experimental drug aims to extend lives in devastating heart disease
NCT ID NCT04973137
Summary
This study tested whether adding the experimental drug birtamimab to standard chemotherapy could help people with a severe, advanced stage of AL amyloidosis, a rare disease where abnormal proteins damage organs like the heart. It specifically enrolled 208 newly diagnosed patients with very serious heart involvement to see if the drug combination could help them live longer. The main goal was to measure the time until death from any cause, comparing the group getting birtamimab to the group getting a placebo, with both groups receiving standard care. The trial was terminated before completion.
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Contacts and locations
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Locations
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AZ Sint-Jan Brugge-Oostende AV
Ostend, Belgium
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Alexandra General Hospital
Athens, Attica, 11528, Greece
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Algemeen Ziekenhuis Sint-Jan Brugge-Oostende - Campus Sint-Jan
Ostend, Oostende, 8400, Belgium
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Ankara UMF
Ankara, Ankara, 06100, Turkey (Türkiye)
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Azienda Ospedaliero-Universitaria Pisana
Pisa, 56124, Italy
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Azienda Ospedaliero-Universitaria di Bologna Policlinico Sant Orsola-Malpighi
Bologna, Bologna, 40138, Italy
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Barbara Ann Karmanos Cancer Institute
Detroit, Michigan, 48201, United States
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Barts Health NHS Trust
London, England, EC1A7BE, United Kingdom
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Barzilai Medical Center
Ashkelon, 7830604, Israel
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Bnai Zion Medical Center
Haifa, Haifa District, 31048, Israel
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Boston University School of Med.
Boston, Massachusetts, 02118, United States
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CHU Nantes
Nantes, Pays de la Loire Region, 44093, France
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CHU UCL Namur (Site Godinne)
Yvoir, Belgium
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CHU de Bordeaux
Bordeaux, France
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Cancer Clinical Trials and Research Unit, Beaumont Hospital
Dublin, Ireland
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Carmel Medical Center
Haifa, 3436212, Israel
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Centre Hospitalier Universitaire Poitiers
Poitiers, Vienne, 86021, France
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Centre Hospitalier Universitaire Universite Catholique de Louvain - Site Godinne
Yvoir, Yvoir, 5530, Belgium
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Centro Hospitalar Universitário Lisboa Norte - Hospital De Santa Maria
Lisbon, Lisbon District, 1649-028, Portugal
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Chonnam National University Hwasun Hospital
Gwangju, Jeollanam-do, 58128, South Korea
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Cleveland Clinic Florida
Weston, Florida, 33331, United States
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Cleveland Clinic Main Campus
Cleveland, Ohio, 44195, United States
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Clinica Universidad de Navarra - Pamplona
Pamplona, Navarre, 31008, Spain
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Clinica Universidad de Navarra -Madrid
Pamplona, Navarre, Spain
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Columbia University Irving Medical Center
New York, New York, 10032, United States
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Complejo Asistencial Universitario de Salamanca - Hospital Clínico
Salamanca, Salamanca, 37007, Spain
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Cork University Hospital
Cork, Munster, T12 DFK4, Ireland
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Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Duke Clinical Research Institute
Durham, North Carolina, 27705, United States
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Ege Universitesi Tip Fakultesi
Izmir, İzmir, 35100, Turkey (Türkiye)
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Fakultni nemocnice ostrava
Ostrava-Poruba, Moravian-Silesian, 70852, Czechia
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Froedtert and Medical College of Wisconsin
Milwaukee, Wisconsin, 53226, United States
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Fukushima Medical University Hospital
Fukushima, Fukushima, 960-1247, Japan
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Gachon University Gil Medical Center
Incheon, 21565, South Korea
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Gazi University
Ankara, Ankara, 06500, Turkey (Türkiye)
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Hackensack University Medical Center
Hackensack, New Jersey, 07601, United States
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Hadassah Medical Center
Jerusalem, Jerusalem, 9112001, Israel
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Hopital Henri Mondor, Creteil
Créteil, France
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Hopital Necker
Paris, Ill-de-France, 75743, France
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Hopital Rangueil
Toulouse, Midi-Pyrenees, 31059, France
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Hospital Clinic of Barcelona
Barcelona, Barcelona, 08036, Spain
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Hospital Josep Trueta ICO Girona
Girona, Girona, 17007, Spain
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Hospital Ramon y Cajal
Madrid, Madrid, 28034, Spain
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Hospital Universitario 12 de Octubre
Vila-real, 1254, Spain
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Hospital Universitario Son Espases
Palma de Mallorca, Balearic Islands, 07120, Spain
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Hospital Universitario de Canarias
Santa Cruz de Tenerife, Santa Cruz de Tenerife, 38320, Spain
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Hospital de Braga
Braga, Braga District, 4710-243, Portugal
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Hôpital Bretonneau
Tours, Centre-Val de Loire, 37044, France
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Hôpital Claude Huriez
Lille, Nord, 59037, France
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Hôpital Haut-Lévêque
Pessac, Gironde, 33604, France
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Hôpital Necker-Enfants Malades
Paris, France
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Hôpitaux Universitaires Henri Mondor
Créteil, Créteil, 94000, France
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Hôpitaux de Brabois
Vandœuvre-lès-Nancy, Lorraine, 54511, France
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Institut Català d'Oncologia - Hospital Duran i Reynals
Barcelona, Barcelona, 08908, Spain
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Institut Català d'Oncologia - Hospital Germans Trias i Pujol
Badalona, Barcelona, 08916, Spain
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Istanbul University Cerrahpasa Medical Faculty
Istanbul, Istanbul, 34320, Turkey (Türkiye)
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Jichi medical university hospital
Shimotsuke, Tochigi, Japan
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Johns Hopkins University
Bethesda, Maryland, 20814-1422, United States
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Kaohsiung Chang Gung Memorial Hospital
Kaohsiung City, Kaohsiung, 833, Taiwan
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Keimyung University Dongsan Hospital
Daegu, Gyeongsangbuk-do, 42601, South Korea
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Klinika Hematologii i Transplantologii
Gdansk, Pomeranian Voivodeship, 80-214, Poland
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Kosin University Gospel Hospital
Busan, 602702, South Korea
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Kyoto Kuramaguchi Medical Center
Kita, Kyoto, Japan
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Maastricht Universitair Medisch Centrum
Maastricht, Limburg, 6229HX, Netherlands
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Manchester University NHS Foundation Trust
Manchester, England, M139WL, United Kingdom
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Mayo Clinic - Rochester
Rochester, Minnesota, 55905, United States
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MedStar Georgetown University Hospital
Washington D.C., District of Columbia, 20007, United States
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Medizinische Universität
Vienna, Austria
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Medizinische Universität Wien
Vienna, Austria
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Nagoya City University Hospital
Aichi, Japan
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National Taiwan University Hospital
Taipei City, Taipei, 10047, Taiwan
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New York University Langone Hospital - Long Island
New York, New York, 11501, United States
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Odense Universitetshospital
Odense, Region Syddanmark, 5000, Denmark
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Paracelsus Medical University
Salzburg, Salzburg, 5020, Austria
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Paracelsus Medical University
Salzburg, Austria
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Perlmutter Cancer Center - 38th Street
New York, New York, 10016, United States
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Pitie-Salpêtrière Hospital
Paris, Ill-de-France, 75013, France
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Pusan National University Hospital
Busan, 49241, South Korea
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Rabin Medical Center - Beilinson Hospital
Ashkelon, Southern District, 7830604, Israel
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Rambam Medical Center
Haifa, Haifa District, 3109601, Israel
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Red Cross Medical Center
Shibuya-ku, Tokyo, 150-8935, Japan
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Roswell Park Comprehensive Cancer Center
Buffalo, New York, 14263, United States
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Royal Perth Hospital
Perth, Western Australia, 6000, Australia
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Royal Victoria Hospital
Montreal, Quebec, H3A1A1, Canada
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SESLHD: St George Hospital
Kogarah, New South Wales, 2217, Australia
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Samsung Medical Center
Seoul, Seoul, 06351, South Korea
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Semmelweis Egyetem - I. sz. Belgyógyászati Klinika
Budapest, Budapest, 1087, Hungary
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Seoul National University Hospital
Seoul, 03080, South Korea
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Severance Hospital
Seoul, Seoul Teugbyeols, 120-752, South Korea
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Shinshu University Hospital
Matsumoto, Nagano, 390-0802, Japan
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Smilow Cancer Hospital Care Center at Trumbull
Trumbull, Connecticut, 06611, United States
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Taipei Veterans General Hospital
Taipei, Taipei, 11217, Taiwan
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The Catholic University of Korea - Seoul St. Mary's Hospital
Seoul, 06591, South Korea
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The Newcastle Upon Tyne Hospitals NHS Foundation Trust
High Heaton, England, NE77DN, United Kingdom
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The Ohio State University College of Medicine
Columbus, Ohio, 43210, United States
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Theagenio Anti-Cancer Hospital of Thessaloniki
Thessaloniki, Central Macedonia, 54007, Greece
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Tom Baker Cancer Centre
Calgary, Alberta, T2N4N2, Canada
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Uniklinik Köln
Köln, Baden-Wurttemberg, 50937, Germany
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Universitair Medisch Centrum Groningen
Groningen, Provincie Groningen, 9713GZ, Netherlands
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University College London Hospitals
London, England, NW12PG, United Kingdom
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University Hospital Marqués de Valdecilla
Santander, Cantabria, 39008, Spain
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University Hospital of Patras
Patra, Peloponnese, 26504, Greece
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University Medicine Mainz
Mainz, Rhineland-Palatinate, 55131, Germany
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University of Nebraska Medical Center
Omaha, Nebraska, 68105, United States
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University of Tennessee Medical Center
Knoxville, Tennessee, 37920, United States
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University of Washington
Seattle, Washington, 98109, United States
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Universitätsklinikum Heidelberg
Heidelberg, Baden-Wurttemberg, 69120, Germany
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Vanderbilt - Ingram Cancer Center - Henry-Joyce Cancer Clinic
Nashville, Tennessee, 37232, United States
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Všeobecná fakultní nemocnice v Praze
Prague, Prague, 12808, Czechia
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Yale Cancer Center
North Haven, Connecticut, 06473, United States
Conditions
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