Race against time: experimental drug aims to extend lives in devastating heart disease

NCT ID NCT04973137

Summary

This study tested whether adding the experimental drug birtamimab to standard chemotherapy could help people with a severe, advanced stage of AL amyloidosis, a rare disease where abnormal proteins damage organs like the heart. It specifically enrolled 208 newly diagnosed patients with very serious heart involvement to see if the drug combination could help them live longer. The main goal was to measure the time until death from any cause, comparing the group getting birtamimab to the group getting a placebo, with both groups receiving standard care. The trial was terminated before completion.

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Contacts and locations

Locations

  • AZ Sint-Jan Brugge-Oostende AV

    Ostend, Belgium

  • Alexandra General Hospital

    Athens, Attica, 11528, Greece

  • Algemeen Ziekenhuis Sint-Jan Brugge-Oostende - Campus Sint-Jan

    Ostend, Oostende, 8400, Belgium

  • Ankara UMF

    Ankara, Ankara, 06100, Turkey (Türkiye)

  • Azienda Ospedaliero-Universitaria Pisana

    Pisa, 56124, Italy

  • Azienda Ospedaliero-Universitaria di Bologna Policlinico Sant Orsola-Malpighi

    Bologna, Bologna, 40138, Italy

  • Barbara Ann Karmanos Cancer Institute

    Detroit, Michigan, 48201, United States

  • Barts Health NHS Trust

    London, England, EC1A7BE, United Kingdom

  • Barzilai Medical Center

    Ashkelon, 7830604, Israel

  • Bnai Zion Medical Center

    Haifa, Haifa District, 31048, Israel

  • Boston University School of Med.

    Boston, Massachusetts, 02118, United States

  • CHU Nantes

    Nantes, Pays de la Loire Region, 44093, France

  • CHU UCL Namur (Site Godinne)

    Yvoir, Belgium

  • CHU de Bordeaux

    Bordeaux, France

  • Cancer Clinical Trials and Research Unit, Beaumont Hospital

    Dublin, Ireland

  • Carmel Medical Center

    Haifa, 3436212, Israel

  • Centre Hospitalier Universitaire Poitiers

    Poitiers, Vienne, 86021, France

  • Centre Hospitalier Universitaire Universite Catholique de Louvain - Site Godinne

    Yvoir, Yvoir, 5530, Belgium

  • Centro Hospitalar Universitário Lisboa Norte - Hospital De Santa Maria

    Lisbon, Lisbon District, 1649-028, Portugal

  • Chonnam National University Hwasun Hospital

    Gwangju, Jeollanam-do, 58128, South Korea

  • Cleveland Clinic Florida

    Weston, Florida, 33331, United States

  • Cleveland Clinic Main Campus

    Cleveland, Ohio, 44195, United States

  • Clinica Universidad de Navarra - Pamplona

    Pamplona, Navarre, 31008, Spain

  • Clinica Universidad de Navarra -Madrid

    Pamplona, Navarre, Spain

  • Columbia University Irving Medical Center

    New York, New York, 10032, United States

  • Complejo Asistencial Universitario de Salamanca - Hospital Clínico

    Salamanca, Salamanca, 37007, Spain

  • Cork University Hospital

    Cork, Munster, T12 DFK4, Ireland

  • Dana-Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

  • Duke Clinical Research Institute

    Durham, North Carolina, 27705, United States

  • Ege Universitesi Tip Fakultesi

    Izmir, İzmir, 35100, Turkey (Türkiye)

  • Fakultni nemocnice ostrava

    Ostrava-Poruba, Moravian-Silesian, 70852, Czechia

  • Froedtert and Medical College of Wisconsin

    Milwaukee, Wisconsin, 53226, United States

  • Fukushima Medical University Hospital

    Fukushima, Fukushima, 960-1247, Japan

  • Gachon University Gil Medical Center

    Incheon, 21565, South Korea

  • Gazi University

    Ankara, Ankara, 06500, Turkey (Türkiye)

  • Hackensack University Medical Center

    Hackensack, New Jersey, 07601, United States

  • Hadassah Medical Center

    Jerusalem, Jerusalem, 9112001, Israel

  • Hopital Henri Mondor, Creteil

    Créteil, France

  • Hopital Necker

    Paris, Ill-de-France, 75743, France

  • Hopital Rangueil

    Toulouse, Midi-Pyrenees, 31059, France

  • Hospital Clinic of Barcelona

    Barcelona, Barcelona, 08036, Spain

  • Hospital Josep Trueta ICO Girona

    Girona, Girona, 17007, Spain

  • Hospital Ramon y Cajal

    Madrid, Madrid, 28034, Spain

  • Hospital Universitario 12 de Octubre

    Vila-real, 1254, Spain

  • Hospital Universitario Son Espases

    Palma de Mallorca, Balearic Islands, 07120, Spain

  • Hospital Universitario de Canarias

    Santa Cruz de Tenerife, Santa Cruz de Tenerife, 38320, Spain

  • Hospital de Braga

    Braga, Braga District, 4710-243, Portugal

  • Hôpital Bretonneau

    Tours, Centre-Val de Loire, 37044, France

  • Hôpital Claude Huriez

    Lille, Nord, 59037, France

  • Hôpital Haut-Lévêque

    Pessac, Gironde, 33604, France

  • Hôpital Necker-Enfants Malades

    Paris, France

  • Hôpitaux Universitaires Henri Mondor

    Créteil, Créteil, 94000, France

  • Hôpitaux de Brabois

    Vandœuvre-lès-Nancy, Lorraine, 54511, France

  • Institut Català d'Oncologia - Hospital Duran i Reynals

    Barcelona, Barcelona, 08908, Spain

  • Institut Català d'Oncologia - Hospital Germans Trias i Pujol

    Badalona, Barcelona, 08916, Spain

  • Istanbul University Cerrahpasa Medical Faculty

    Istanbul, Istanbul, 34320, Turkey (Türkiye)

  • Jichi medical university hospital

    Shimotsuke, Tochigi, Japan

  • Johns Hopkins University

    Bethesda, Maryland, 20814-1422, United States

  • Kaohsiung Chang Gung Memorial Hospital

    Kaohsiung City, Kaohsiung, 833, Taiwan

  • Keimyung University Dongsan Hospital

    Daegu, Gyeongsangbuk-do, 42601, South Korea

  • Klinika Hematologii i Transplantologii

    Gdansk, Pomeranian Voivodeship, 80-214, Poland

  • Kosin University Gospel Hospital

    Busan, 602702, South Korea

  • Kyoto Kuramaguchi Medical Center

    Kita, Kyoto, Japan

  • Maastricht Universitair Medisch Centrum

    Maastricht, Limburg, 6229HX, Netherlands

  • Manchester University NHS Foundation Trust

    Manchester, England, M139WL, United Kingdom

  • Mayo Clinic - Rochester

    Rochester, Minnesota, 55905, United States

  • MedStar Georgetown University Hospital

    Washington D.C., District of Columbia, 20007, United States

  • Medizinische Universität

    Vienna, Austria

  • Medizinische Universität Wien

    Vienna, Austria

  • Nagoya City University Hospital

    Aichi, Japan

  • National Taiwan University Hospital

    Taipei City, Taipei, 10047, Taiwan

  • New York University Langone Hospital - Long Island

    New York, New York, 11501, United States

  • Odense Universitetshospital

    Odense, Region Syddanmark, 5000, Denmark

  • Paracelsus Medical University

    Salzburg, Salzburg, 5020, Austria

  • Paracelsus Medical University

    Salzburg, Austria

  • Perlmutter Cancer Center - 38th Street

    New York, New York, 10016, United States

  • Pitie-Salpêtrière Hospital

    Paris, Ill-de-France, 75013, France

  • Pusan National University Hospital

    Busan, 49241, South Korea

  • Rabin Medical Center - Beilinson Hospital

    Ashkelon, Southern District, 7830604, Israel

  • Rambam Medical Center

    Haifa, Haifa District, 3109601, Israel

  • Red Cross Medical Center

    Shibuya-ku, Tokyo, 150-8935, Japan

  • Roswell Park Comprehensive Cancer Center

    Buffalo, New York, 14263, United States

  • Royal Perth Hospital

    Perth, Western Australia, 6000, Australia

  • Royal Victoria Hospital

    Montreal, Quebec, H3A1A1, Canada

  • SESLHD: St George Hospital

    Kogarah, New South Wales, 2217, Australia

  • Samsung Medical Center

    Seoul, Seoul, 06351, South Korea

  • Semmelweis Egyetem - I. sz. Belgyógyászati Klinika

    Budapest, Budapest, 1087, Hungary

  • Seoul National University Hospital

    Seoul, 03080, South Korea

  • Severance Hospital

    Seoul, Seoul Teugbyeols, 120-752, South Korea

  • Shinshu University Hospital

    Matsumoto, Nagano, 390-0802, Japan

  • Smilow Cancer Hospital Care Center at Trumbull

    Trumbull, Connecticut, 06611, United States

  • Taipei Veterans General Hospital

    Taipei, Taipei, 11217, Taiwan

  • The Catholic University of Korea - Seoul St. Mary's Hospital

    Seoul, 06591, South Korea

  • The Newcastle Upon Tyne Hospitals NHS Foundation Trust

    High Heaton, England, NE77DN, United Kingdom

  • The Ohio State University College of Medicine

    Columbus, Ohio, 43210, United States

  • Theagenio Anti-Cancer Hospital of Thessaloniki

    Thessaloniki, Central Macedonia, 54007, Greece

  • Tom Baker Cancer Centre

    Calgary, Alberta, T2N4N2, Canada

  • Uniklinik Köln

    Köln, Baden-Wurttemberg, 50937, Germany

  • Universitair Medisch Centrum Groningen

    Groningen, Provincie Groningen, 9713GZ, Netherlands

  • University College London Hospitals

    London, England, NW12PG, United Kingdom

  • University Hospital Marqués de Valdecilla

    Santander, Cantabria, 39008, Spain

  • University Hospital of Patras

    Patra, Peloponnese, 26504, Greece

  • University Medicine Mainz

    Mainz, Rhineland-Palatinate, 55131, Germany

  • University of Nebraska Medical Center

    Omaha, Nebraska, 68105, United States

  • University of Tennessee Medical Center

    Knoxville, Tennessee, 37920, United States

  • University of Washington

    Seattle, Washington, 98109, United States

  • Universitätsklinikum Heidelberg

    Heidelberg, Baden-Wurttemberg, 69120, Germany

  • Vanderbilt - Ingram Cancer Center - Henry-Joyce Cancer Clinic

    Nashville, Tennessee, 37232, United States

  • Všeobecná fakultní nemocnice v Praze

    Prague, Prague, 12808, Czechia

  • Yale Cancer Center

    North Haven, Connecticut, 06473, United States

Conditions

Explore the condition pages connected to this study.