New drug combo takes on tough lung cancer
NCT ID NCT05990738
First seen Jun 27, 2026 · Last updated Aug 05, 2026 · Updated 5 times
Summary
This early-stage trial tests a new antibody-like drug called BI 764532 alongside standard chemotherapy in adults with advanced small cell lung cancer that has returned after platinum-based treatment. The main goal is to find a safe dose and check for side effects. About 69 participants will receive the combination and be monitored regularly.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- BI 764532 (Obrixtamig) plus topotecan or other single-agent chemotherapy
- What this could lead to
- If it works, this could point toward a new combination treatment for small cell lung cancer that has stopped responding to standard chemotherapy.
- What could go wrong
- This is an early Phase 1 safety trial with only 69 participants, so it is too small to prove effectiveness. The drug may cause side effects or fail to shrink tumors.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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HOP Civil
Strasbourg, 67091, France
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INS Curie
Paris, 75005, France
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Institut Gustave Roussy
Villejuif, 94805, France
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Leicester Royal Infirmary
Leicester, LE1 5WW, United Kingdom
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Mayo Clinic - Florida
Jacksonville, Florida, 32224, United States
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MedStar Georgetown University Hospital
Washington D.C., District of Columbia, 20007, United States
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Polish Mother's Memorial Hospital - Research Institute
Lodz, 93-338, Poland
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Thoraxklinik-Heidelberg gGmbH am Universitätsklinikum Heidelberg
Heidelberg, 69126, Germany
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University of Miami
Miami, Florida, 33136, United States
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Universitätsklinikum Carl Gustav Carus Dresden
Dresden, 01307, Germany
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Universitätsklinikum Erlangen
Erlangen, 91054, Germany
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Universitätsklinikum Würzburg AÖR
Würzburg, 97078, Germany
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Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Mainz, 55131, Germany
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Virginia Commonwealth University
Richmond, Virginia, 23219, United States
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