First patients test new pill targeting tough stomach cancers

NCT ID NCT06056024

Summary

This was a first-in-human study to find a safe and tolerable dose of a new oral drug, BI 3706674, for adults with advanced stomach or esophageal cancer that had stopped responding to other treatments. The trial tested different dose levels to see how the drug was processed by the body and whether it could shrink tumors. It specifically enrolled patients whose cancer had a certain genetic feature (KRAS wild type amplified).

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Contacts and locations

Locations

  • Ajou University Hospital

    Suwon, 16499, South Korea

  • Asan Medical Center

    Seoul, 05505, South Korea

  • Japanese Foundation for Cancer Research

    Tokyo, Koto-ku, 135-8550, Japan

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • Mayo Clinic-Arizona

    Phoenix, Arizona, 85054, United States

  • Memorial Sloan-Kettering Cancer Center

    New York, New York, 10065, United States

  • NCKUH

    Tainan, 704, Taiwan

  • National Cancer Center Hospital East

    Chiba, Kashiwa, 277-8577, Japan

  • National Taiwan University Hospital

    Taipei, 100, Taiwan

  • Samsung Medical Center

    Seoul, 135-710, South Korea

  • Seoul National University Bundang Hospital

    Seongnam, 13620, South Korea

  • Seoul National University Hospital

    Seoul, 03080, South Korea

  • Severance Hospital

    Seoul, 03722, South Korea

  • The Catholic University of Korea, Seoul St.Mary's Hospital

    Seoul, 137-701, South Korea

  • The University of Texas MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • University of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States

  • Yale Cancer Center

    New Haven, Connecticut, 06511, United States

Conditions

Explore the condition pages connected to this study.