New drug combo takes aim at Hard-to-Treat KRAS cancers
NCT ID NCT04973163
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-phase study tests a new drug, BI 1823911, alone or with another drug (BI 1701963), in people with advanced solid tumors that have a KRAS G12C mutation. The goal is to find a safe dose and see if the drugs can shrink tumors. About 30 adults with cancers like lung, colorectal, or pancreatic cancer who have run out of other options are taking part.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- BI 1823911 (a KRAS inhibitor) and BI 1701963 (another KRAS-targeting drug)
- What this could lead to
- If successful, this could point toward a new treatment option for people with advanced cancers that have a specific KRAS mutation.
- What could go wrong
- This is a very early (Phase 1) trial with only 30 participants, so safety and effectiveness are not yet known. The drugs may not shrink tumors or could cause side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Brussels - HOSP Jules Bordet
Anderlecht/Brussels-Capital, 1070, Belgium
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Edegem - UNIV UZ Antwerpen
Edegem/Antwerpen, 2650, Belgium
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Hospital Universitari Vall D Hebron
Barcelona, 08035, Spain
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Memorial Sloan-Kettering Cancer Center
New York, New York, 10021, United States
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Sarah Cannon Research Institute at Mary Crowley
Dallas, Texas, 75230, United States
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The Christie
Manchester, M20 4BX, United Kingdom
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The University of Texas MD Anderson Cancer Center
Houston, Texas, 77030, United States
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UZ Leuven
Leuven/Vlaams-Brabant, 3000, Belgium
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Universitair Ziekenhuis Gent
Gent/Oost-Vlaanderen, 9000, Belgium