Cancer-Killing virus tested in humans for first time

NCT ID NCT05839600

Terminated Disease control Sponsor: Boehringer Ingelheim Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase trial tested a new immunotherapy called BI 1821736 in 10 adults with advanced solid tumors that had not responded to standard treatments. BI 1821736 is a specially designed virus meant to kill cancer cells and help the immune system fight the cancer. Participants received the drug every 3 weeks for up to 3 months, and doctors monitored safety and tumor response. The study was terminated early, so only limited safety and dosing information is available.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: BI 1821736 (a virus that kills cancer cells and boosts the immune system)
What this could lead to: If it works, this could point toward a new treatment option for advanced solid tumors that have not responded to other therapies.
What could go wrong: This was a very early, small trial (10 people) that was terminated, so results are limited. The virus may cause side effects or not shrink tumors.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for ADVANCED SOLID TUMOR are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SOLID TUMORS

Contacts and locations

Locations

Hospital Clínic de Barcelona

Barcelona, 08036, Spain
Hospital Quiron. I.C.U.

Barcelona, 08023, Spain
Hospital Universitario 12 de Octubre

Madrid, 28041, Spain
Instituto Valenciano de Oncología

Valencia, 46009, Spain
Karolinska Universitetssjukhuset Stockholm

Stockholm, 17177, Sweden
NEXT Oncology-San Antonio-65273

San Antonio, Texas, 78229, United States
Princess Margaret Cancer Centre

Toronto, Ontario, M5G 2M9, Canada
Yale Cancer Center

New Haven, Connecticut, 06511, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.