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New drug combo aims to boost immune system against advanced cancers

NCT ID NCT05471856

Recruiting now Disease control Sponsor: Boehringer Ingelheim Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 23, 2026 · Updated 2 times

Summary

This study tests a new drug, BI 1703880, combined with ezabenlimab in adults with advanced solid tumors that haven't responded to other treatments. The main goal is to find a safe dose of BI 1703880. Participants receive both drugs as infusions, with BI 1703880 given weekly then every 3 weeks, and ezabenlimab every 3 weeks. The study focuses on safety and how the body processes the drugs, not on curing the cancer.

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Conditions

The condition(s) this trial relates to.

neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SOLID TUMORS

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • CIO Clara Campal

    RECRUITING

    Madrid, 28050, Spain

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Churchill Hospital

    RECRUITING

    Oxford, OX3 7LE, United Kingdom

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Hospital Clinico Universitario de Valencia

    RECRUITING

    Valencia, 46010, Spain

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Hospital Universitari Vall d'Hebron

    RECRUITING

    Barcelona, 08035, Spain

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Instituto Valenciano de Oncología

    RECRUITING

    Valencia, 46009, Spain

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Japanese Foundation for Cancer Research

    RECRUITING

    Tokyo, Koto-ku, 135-8550, Japan

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • John Theurer Cancer Center

    RECRUITING

    Hackensack, New Jersey, 07601, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • National Cancer Center Hospital East

    RECRUITING

    Chiba, Kashiwa, 277-8577, Japan

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Saitama Medical University International Medical Center

    RECRUITING

    Saitama, Hidaka, 350-1298, Japan

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • The Royal Marsden Hospital, Chelsea

    RECRUITING

    London, SW3 6JJ, United Kingdom

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • The Royal Marsden Hospital, Sutton

    RECRUITING

    Sutton, SM2 5PT, United Kingdom

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Valkyrie Clinical Trials

    RECRUITING

    Los Angeles, California, 90067, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Yale University School of Medicine

    RECRUITING

    New Haven, Connecticut, 06511, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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