New RAF blocker tested for tough tumors, but study halted early
NCT ID NCT04249843
First seen Nov 01, 2025 · Last updated May 09, 2026 · Updated 24 times
Summary
This early-phase study tested a new oral drug, BGB-3245, designed to block a protein called RAF that helps some tumors grow. It involved 109 adults with advanced solid tumors that had a specific BRAF mutation and had stopped responding to other treatments. The main goals were to check the drug's safety and find the right dose, but the study was terminated early, so results are limited.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Blacktown Hospital
Blacktown, New South Wales, 2148, Australia
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Cedars Sinai Medical Center
Beverly Hills, California, 90212, United States
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MD Anderson
Houston, Texas, 77030, United States
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Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
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Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
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One Clinical Research
Nedlands, Perth, 6009, Australia
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Peter MacCallum Cancer Centre
Melbourne, Victoria, 2010, Australia
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The Kinghorn Cancer Centre, St Vincent Hospital Sydney
Sydney, New South Wales, 2010, Australia
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University of Virginia Comprehensive Cancer Centre
Charlottesville, Virginia, 22903, United States
Conditions
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