New behavioral therapy aims to tame tantrums in rare genetic disorder
NCT ID NCT05829668
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a behavioral therapy for children with Cornelia de Lange syndrome (CdLS) who have problem behaviors like aggression or self-injury. Researchers will identify what triggers these behaviors and then train parents to use a tailored treatment. The goal is to reduce problem behaviors by at least 80%. The study involves 20 children and their families, with some serving as a comparison group.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- ABA-based functional analysis and behavioral treatment
- What this could lead to
- If successful, this could provide an effective, non-drug way to reduce problem behaviors like aggression and tantrums in children with Cornelia de Lange syndrome.
- What could go wrong
- This is a small, early-stage study with only 20 participants, so results may not apply to all children. The treatment requires intensive clinic visits and parent training, which may be hard to sustain.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Kennedy Krieger Institute
RECRUITINGBaltimore, Maryland, 21205, United States
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