Bladder cancer vaccine showdown: which BCG works best?

NCT ID NCT03091660

Ongoing Disease control Sponsor: SWOG Cancer Research Network Source: ClinicalTrials.gov ↗

First seen Apr 12, 2026 · Last updated May 15, 2026 · Updated 3 times

Summary

This large phase 3 trial tests whether a different strain of BCG (a bacteria that boosts the immune system) or adding a BCG skin shot before the standard bladder treatment can better prevent high-grade bladder cancer from coming back. About 1000 patients with early-stage bladder cancer that hasn't spread to muscle will be randomly assigned to one of three treatment groups. The goal is to find the most effective way to keep the cancer from returning.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Arnot Ogden Medical Center/Falck Cancer Center

Elmira, New York, 14905, United States
Atlanta VA Medical Center

Decatur, Georgia, 30033, United States
Audie L Murphy VA Hospital

San Antonio, Texas, 78229, United States
Banner MD Anderson Cancer Center

Gilbert, Arizona, 85234, United States
Baptist MD Anderson Cancer Center

Jacksonville, Florida, 32207, United States
Bay Area Hospital

Coos Bay, Oregon, 97420, United States
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center

Houston, Texas, 77030, United States
Benefis Healthcare- Sletten Cancer Institute

Great Falls, Montana, 59405, United States
Brigham and Women's Hospital

Boston, Massachusetts, 02115, United States
Cancer Care Center of O'Fallon

O'Fallon, Illinois, 62269, United States
Cancer Care Specialists of Illinois - Decatur

Decatur, Illinois, 62526, United States
Carle Cancer Center

Urbana, Illinois, 61801, United States
Carle Physician Group-Effingham

Effingham, Illinois, 62401, United States
Carle Physician Group-Mattoon/Charleston

Mattoon, Illinois, 61938, United States
Carle on Vermilion

Danville, Illinois, 61832, United States
Cedars Sinai Medical Center

Los Angeles, California, 90048, United States
Centralia Oncology Clinic

Centralia, Illinois, 62801, United States
City of Hope Comprehensive Cancer Center

Duarte, California, 91010, United States
Comprehensive Cancer Centers of Nevada

Las Vegas, Nevada, 89148, United States
Comprehensive Cancer Centers of Nevada - Central Valley

Las Vegas, Nevada, 89169, United States
Comprehensive Cancer Centers of Nevada - Henderson

Henderson, Nevada, 89052, United States
Comprehensive Cancer Centers of Nevada - Northwest

Las Vegas, Nevada, 89128, United States
Comprehensive Cancer Centers of Nevada - Town Center

Las Vegas, Nevada, 89144, United States
Comprehensive Cancer Centers of Nevada-Horizon Ridge

Henderson, Nevada, 89052, United States
Comprehensive Cancer Centers of Nevada-Southeast Henderson

Henderson, Nevada, 89074, United States
Comprehensive Cancer Centers of Nevada-Summerlin

Las Vegas, Nevada, 89144, United States
Crossroads Cancer Center

Effingham, Illinois, 62401, United States
Decatur Memorial Hospital

Decatur, Illinois, 62526, United States
East Jefferson General Hospital

Metairie, Louisiana, 70006, United States
Englewood Hospital and Medical Center

Englewood, New Jersey, 07631, United States
Farmington Health Center

Farmington, Utah, 84025, United States
Fred Hutchinson Cancer Research Center

Seattle, Washington, 98109, United States
George Washington University Medical Center

Washington D.C., District of Columbia, 20037, United States
Good Samaritan Regional Health Center

Mount Vernon, Illinois, 62864, United States
Gundersen Lutheran Medical Center

La Crosse, Wisconsin, 54601, United States
Hawaii Cancer Care - Savio

‘Aiea, Hawaii, 96701, United States
Hawaii Cancer Care Inc - Waterfront Plaza

Honolulu, Hawaii, 96813, United States
Henry Ford Cancer Institute-Downriver

Brownstown, Michigan, 48183, United States
Henry Ford Hospital

Detroit, Michigan, 48202, United States
Henry Ford Macomb Hospital-Clinton Township

Clinton Township, Michigan, 48038, United States
Henry Ford Medical Center-Columbus

Novi, Michigan, 48377, United States
Henry Ford Medical Center-Fairlane

Dearborn, Michigan, 48126, United States
Henry Ford West Bloomfield Hospital

West Bloomfield, Michigan, 48322, United States
Hope Cancer Care of Nevada

Las Vegas, Nevada, 89103, United States
Houston Methodist Hospital

Houston, Texas, 77030, United States
Huntsman Cancer Institute/University of Utah

Salt Lake City, Utah, 84112, United States
Indu and Raj Soin Medical Center

Beavercreek, Ohio, 45431, United States
Island Urology

Honolulu, Hawaii, 96813, United States
Island Urology-Hilo

Hilo, Hawaii, 96720, United States
Johns Hopkins University/Sidney Kimmel Cancer Center

Baltimore, Maryland, 21287, United States
Kaiser Permanente-Oakland

Oakland, California, 94611, United States
Kaiser Permanente-South Sacramento

Sacramento, California, 95823, United States
Kaiser Permanente-Vallejo

Vallejo, California, 94589, United States
Kaiser Permanente-Walnut Creek

Walnut Creek, California, 94596, United States
Kettering Medical Center

Kettering, Ohio, 45429, United States
LSU Health Sciences Center at Shreveport

Shreveport, Louisiana, 71103, United States
LSU Healthcare Network / Metairie Multi-Specialty Clinic

Metairie, Louisiana, 70006, United States
Las Vegas Prostate Cancer Center

Las Vegas, Nevada, 89113, United States
Las Vegas Urology - Cathedral Rock

Las Vegas, Nevada, 89128, United States
Las Vegas Urology - Green Valley

Henderson, Nevada, 89074, United States
Las Vegas Urology - Pebble

Henderson, Nevada, 89074, United States
Las Vegas Urology - Pecos

Las Vegas, Nevada, 89074, United States
Las Vegas Urology - Smoke Ranch

Las Vegas, Nevada, 89128, United States
Las Vegas Urology - Sunset

Las Vegas, Nevada, 89113, United States
Laura and Isaac Perlmutter Cancer Center at NYU Langone

New York, New York, 10016, United States
Los Angeles County-USC Medical Center

Los Angeles, California, 90033, United States
Louisiana State University Health Science Center

New Orleans, Louisiana, 70112, United States
Loyola University Medical Center

Maywood, Illinois, 60153, United States
M D Anderson Cancer Center

Houston, Texas, 77030, United States
Madigan Army Medical Center

Tacoma, Washington, 98431, United States
Marshfield Clinic - Ladysmith Center

Ladysmith, Wisconsin, 54848, United States
Marshfield Clinic - Wisconsin Rapids Center

Wisconsin Rapids, Wisconsin, 54494, United States
Marshfield Clinic Stevens Point Center

Stevens Point, Wisconsin, 54482, United States
Marshfield Clinic-Chippewa Center

Chippewa Falls, Wisconsin, 54729, United States
Marshfield Clinic-Minocqua Center

Minocqua, Wisconsin, 54548, United States
Marshfield Clinic-Wausau Center

Wausau, Wisconsin, 54401, United States
Marshfield Medical Center - Weston

Weston, Wisconsin, 54476, United States
Marshfield Medical Center-EC Cancer Center

Eau Claire, Wisconsin, 54701, United States
Marshfield Medical Center-Marshfield

Marshfield, Wisconsin, 54449, United States
Marshfield Medical Center-Rice Lake

Rice Lake, Wisconsin, 54868, United States
Mayo Clinic Hospital in Arizona

Phoenix, Arizona, 85054, United States
Mayo Clinic in Arizona

Scottsdale, Arizona, 85259, United States
MedStar Washington Hospital Center

Washington D.C., District of Columbia, 20010, United States
Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
Memorial Medical Center

Springfield, Illinois, 62781, United States
Memorial Sloan Kettering Basking Ridge

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Memorial Sloan Kettering Commack

Commack, New York, 11725, United States
Memorial Sloan Kettering Monmouth

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau

Uniondale, New York, 11553, United States
Memorial Sloan Kettering Westchester

East White Plains, New York, 10604, United States
Mercy Hospital Oklahoma City

Oklahoma City, Oklahoma, 73120, United States
Mercy Hospital Saint Louis

St Louis, Missouri, 63141, United States
Mercy Hospital Springfield

Springfield, Missouri, 65804, United States
Moffitt Cancer Center

Tampa, Florida, 33612, United States
Moffitt Cancer Center - McKinley Campus

Tampa, Florida, 33612, United States
Northwestern University

Chicago, Illinois, 60611, United States
Ochsner Medical Center Jefferson

New Orleans, Louisiana, 70121, United States
Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210, United States
OptumCare Cancer Care at Fort Apache

Las Vegas, Nevada, 89148, United States
OptumCare Cancer Care at MountainView

Las Vegas, Nevada, 89128, United States
OptumCare Cancer Care at Oakey

Las Vegas, Nevada, 89102, United States
OptumCare Cancer Care at Seven Hills

Henderson, Nevada, 89052, United States
Oregon Health and Science University

Portland, Oregon, 97239, United States
Pali Momi Medical Center

‘Aiea, Hawaii, 96701, United States
Portland VA Medical Center

Portland, Oregon, 97239, United States
Prisma Health Cancer Institute - Butternut

Greenville, South Carolina, 29605, United States
Prisma Health Cancer Institute - Easley

Easley, South Carolina, 29640, United States
Prisma Health Cancer Institute - Eastside

Greenville, South Carolina, 29615, United States
Prisma Health Cancer Institute - Faris

Greenville, South Carolina, 29605, United States
Prisma Health Cancer Institute - Greer

Greer, South Carolina, 29650, United States
Prisma Health Cancer Institute - Laurens

Clinton, South Carolina, 29325, United States
Prisma Health Cancer Institute - Seneca

Seneca, South Carolina, 29672, United States
Prisma Health Cancer Institute - Spartanburg

Boiling Springs, South Carolina, 29316, United States
Prisma Health Greenville Memorial Hospital

Greenville, South Carolina, 29605, United States
Queen's Cancer Cenrer - POB I

Honolulu, Hawaii, 96813, United States
Queen's Cancer Center - Kuakini

Honolulu, Hawaii, 96817, United States
Queen's Cancer Center - Pearlridge

‘Aiea, Hawaii, 96701, United States
Queen's Medical Center

Honolulu, Hawaii, 96813, United States
Radiation Oncology Centers of Nevada Central

Las Vegas, Nevada, 89106, United States
Ralph H Johnson VA Medical Center

Charleston, South Carolina, 29401, United States
Renown Regional Medical Center

Reno, Nevada, 89502, United States
Rogue Valley Medical Center

Medford, Oregon, 97504, United States
Roswell Park Cancer Institute

Buffalo, New York, 14263, United States
Saint Alphonsus Cancer Care Center-Boise

Boise, Idaho, 83706, United States
Saint Alphonsus Cancer Care Center-Caldwell

Caldwell, Idaho, 83605, United States
Saint Alphonsus Medical Center-Nampa

Nampa, Idaho, 83686, United States
Saint Alphonsus Medical Center-Ontario

Ontario, Oregon, 97914, United States
Saint Francis Medical Center

Cape Girardeau, Missouri, 63703, United States
Saint John Macomb-Oakland Hospital

Warren, Michigan, 48093, United States
Saint Joseph Mercy Hospital

Ann Arbor, Michigan, 48106, United States
Saint Luke's Cancer Institute - Boise

Boise, Idaho, 83712, United States
Saint Luke's Cancer Institute - Fruitland

Fruitland, Idaho, 83619, United States
Saint Luke's Cancer Institute - Meridian

Meridian, Idaho, 83642, United States
Saint Luke's Cancer Institute - Nampa

Nampa, Idaho, 83686, United States
Saint Luke's Cancer Institute - Twin Falls

Twin Falls, Idaho, 83301, United States
Seattle Cancer Care Alliance

Seattle, Washington, 98109, United States
Smilow Cancer Center/Yale-New Haven Hospital

New Haven, Connecticut, 06510, United States
South Jordan Health Center

South Jordan, Utah, 84009, United States
Southern Illinois University School of Medicine

Springfield, Illinois, 62702, United States
Sparrow Hospital

Lansing, Michigan, 48912, United States
Springfield Clinic

Springfield, Illinois, 62702, United States
Stanford Cancer Institute Palo Alto

Palo Alto, California, 94304, United States
State University of New York Upstate Medical University

Syracuse, New York, 13210, United States
Straub Clinic and Hospital

Honolulu, Hawaii, 96813, United States
The Carle Foundation Hospital

Urbana, Illinois, 61801, United States
Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, 19107, United States
UC Irvine Health/Chao Family Comprehensive Cancer Center

Orange, California, 92868, United States
UCSF Medical Center-Mission Bay

San Francisco, California, 94158, United States
UNC Lineberger Comprehensive Cancer Center

Chapel Hill, North Carolina, 27599, United States
USC / Norris Comprehensive Cancer Center

Los Angeles, California, 90033, United States
UT Southwestern/Simmons Cancer Center-Dallas

Dallas, Texas, 75390, United States
UTMB Cancer Center at Victory Lakes

League City, Texas, 77573, United States
University Hospital

San Antonio, Texas, 78229, United States
University Medical Center New Orleans

New Orleans, Louisiana, 70112, United States
University of Colorado Hospital

Aurora, Colorado, 80045, United States
University of Florida Health Science Center - Gainesville

Gainesville, Florida, 32610, United States
University of Hawaii Cancer Center

Honolulu, Hawaii, 96813, United States
University of Illinois

Chicago, Illinois, 60612, United States
University of Iowa/Holden Comprehensive Cancer Center

Iowa City, Iowa, 52242, United States
University of Kansas Hospital-Westwood Cancer Center

Westwood, Kansas, 66205, United States
University of Michigan Comprehensive Cancer Center

Ann Arbor, Michigan, 48109, United States
University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104, United States
University of Rochester

Rochester, New York, 14642, United States
University of South Alabama Mitchell Cancer Institute

Mobile, Alabama, 36688, United States
University of Texas Health Science Center at San Antonio

San Antonio, Texas, 78229, United States
University of Texas Medical Branch

Galveston, Texas, 77555-0565, United States
University of Washington Medical Center - Montlake

Seattle, Washington, 98195, United States
Urology Specialists of Nevada - Central

Las Vegas, Nevada, 89106, United States
Urology Specialists of Nevada - Green Valley

Henderson, Nevada, 89074, United States
Urology Specialists of Nevada - Northwest

Las Vegas, Nevada, 89128, United States
Urology Specialists of Nevada - Southwest

Las Vegas, Nevada, 89148, United States
West Virginia University Healthcare

Morgantown, West Virginia, 26506, United States
Yale University

New Haven, Connecticut, 06520, United States

Conditions

Explore the condition pages connected to this study.

STAGE 0 BLADDER UROTHELIAL CARCINOMA STAGE 0IS BLADDER UROTHELIAL CARCINOMA STAGE 0IS BLADDER UROTHELIAL CARCINOMA STAGE I BLADDER UROTHELIAL CARCINOMA STAGE I BLADDER UROTHELIAL CARCINOMA