New CAR t therapy targets tough lymphoma
NCT ID NCT05370430
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial is testing a new type of immune cell therapy called BAFFR-CAR T cells for people with relapsed or refractory B-cell Non-Hodgkin's lymphoma. The study aims to find a safe dose and check for side effects. About 36 adults whose cancer has not responded to prior treatments will take part.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- BAFFR-CAR T cells (a type of immune cell therapy)
- What this could lead to
- If it works, this could offer a new treatment option for patients with B-cell lymphoma who have not responded to other therapies.
- What could go wrong
- This is a very early Phase 1 trial with only 36 participants, so it is primarily testing safety and dosing. The therapy may not work, and there are risks like cytokine release syndrome and neurotoxicity.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Atrium Health Levine Cancer Institute - Morehead
RECRUITINGCharlotte, North Carolina, 28204, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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City of Hope Medical Center
RECRUITINGDuarte, California, 91010, United States
Contact
Contact Email: •••••@•••••
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Providence Swedish Cancer Institute
RECRUITINGSeattle, Washington, 98104, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Stanford University
RECRUITINGStanford, California, 94305, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Kansas Hospital
RECRUITINGKansas City, Kansas, 66160, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Minnesota
RECRUITINGMinneapolis, Minnesota, 55455, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••