Could a genetically tweaked bacteria shrink Hard-to-Treat tumors?
NCT ID NCT05120596
First seen Apr 17, 2026 · Last updated May 13, 2026 · Updated 5 times
Summary
This study tests a genetically modified, weakened bacteria (T3P-Y058-739) in about 100 adults with advanced solid tumors that have no standard treatment options. The bacteria is given alone or with the immunotherapy drug pembrolizumab, either as an injection into the tumor or into a vein. The goal is to find a safe dose and see if it can shrink tumors or slow their growth.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Locations
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Cancer Research UK Clinical trials; Unit Partner in CaCTUS- Cancer clinical trials Unit Scotland; Beatson West of Scotland Cancer Centre
RECRUITINGGlasgow, G12 0YN, United Kingdom
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Centre Hospitalier Universitaire Vaudois Lausanne (CHUV)
RECRUITINGLausanne, 1011, Switzerland
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Clinica Universidad de Navarra
RECRUITINGPamplona, Navarre, 31008, Spain
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Clinica Universidad de Navarra
RECRUITINGMadrid, 28027, Spain
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Hospital Clínico Universitario de Valencia (INCLIVA)
RECRUITINGValencia, 46010, Spain
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Hospital Universitario 12 De Octubre
RECRUITINGMadrid, 28041, Spain
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Hospital Universitario La Paz
RECRUITINGMadrid, 28046, Spain
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Institut Catala D'oncologia
RECRUITINGL'Hospitalet de Llobregat, 08908, Spain
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Leeds Clinical Research Facility
RECRUITINGLeeds, LS9 7TF, United Kingdom
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Royal Marsden NHS Foundation Trust
RECRUITINGLondon, SW3 6JJ, United Kingdom
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START Madrid-CIOCC Hospital Univ. HM Sanchinarro
RECRUITINGMadrid, 28050, Spain
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University Hospital Bern (Inselspital)
RECRUITINGBern, 3010, Switzerland
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University Hospital Southampton NHS Foundation Trust
RECRUITINGSouthampton, SO16 6YD, United Kingdom
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University Hospital of Zürich (Universitätsspital Zürich)
RECRUITINGZurich, 8091, Switzerland
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Vall d'Hebron Institute of Oncology
RECRUITINGBarcelona, 08035, Spain
Contact
Conditions
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