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New hope for Post-Surgery sugar crashes: avexitide trial underway

NCT ID NCT06747468

Ongoing Disease control Sponsor: Amylyx Pharmaceuticals Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a drug called avexitide in 75 adults who have dangerous low blood sugar episodes after gastric bypass surgery. Participants receive either the drug or a placebo for 16 weeks to see if it reduces severe sugar crashes. The goal is to control this long-term condition, not cure it.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

dumping syndrome hypoglycemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

POST-BARIATRIC HYPOGLYCEMIA

Contacts and locations

Locations

  • Brigham and Women's Hospital

    Boston, Massachusetts, 02115, United States

  • Centricity Research Morehead City Multispecialty

    Morehead City, North Carolina, 28557-3126, United States

  • Cleveland Clinic

    Cleveland, Ohio, 44195-0001, United States

  • Consano Clinical Research

    Shavano Park, Texas, 78231-1281, United States

  • Cotton-O'Neil Diabetes and Endocrinology Center

    Topeka, Kansas, 66606-2806, United States

  • Diabetes and Gandular Disease Clinic

    San Antonio, Texas, 78229-4801, United States

  • Duke Center for Metabolic and Weight Loss Surgery

    Durham, North Carolina, 27704-2726, United States

  • East Coast Institute for Research

    Jacksonville, Florida, 32216, United States

  • Endocrine and Psychiatry Center

    Houston, Texas, 77095-2856, United States

  • Georgia Clincal Research

    Lawrenceville, Georgia, 30044, United States

  • Hanson Diabetes Center

    Port Charlotte, Florida, 33952-6722, United States

  • Joslin Diabetes Center

    Boston, Massachusetts, 02215-5306, United States

  • NYC Health + Hospitals/Queens - BRANY

    New Hyde Park, New York, 11042-1214, United States

  • Penn Medicine University City

    Philadelphia, Pennsylvania, 19104, United States

  • Southern Endocrinology & Diabetes Associates

    Mesquite, Texas, 75149, United States

  • Stanford Health Care - Endocrinology Clinic

    Stanford, California, 94304, United States

  • Texas Valley Clinical Research, LLC

    Weslaco, Texas, 78596-7288, United States

  • UT Health San Antonio

    San Antonio, Texas, 78229-3931, United States

  • UWHealth - Junction Rd Medical Center Endocrinology Clinic

    Madison, Wisconsin, 53717-2656, United States

  • University of Colorado Health Anschutz Medical Campus

    Aurora, Colorado, 80045-2541, United States

  • Vanderbilt Weight Loss Center

    Nashville, Tennessee, 37212-3609, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.