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New hope for advanced bladder cancer: maintenance drug aims to keep tumors in check

NCT ID NCT07460245

Not yet recruiting Disease control Sponsor: Gruppo Oncologico Italiano di Ricerca Clinica Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether the drug avelumab can help keep metastatic urothelial carcinoma (a type of bladder cancer) from growing after patients have already received two lines of chemotherapy. About 144 adults whose cancer has not worsened after second-line chemo will receive avelumab as maintenance therapy. The goal is to see if this approach extends the time before the cancer progresses.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

transitional cell carcinoma urothelial carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

UROTHELIAL CARCINOMA

Contacts and locations

Locations

  • AO Santa Maria della Misericordia di Perugia-Struttura Complessa di Oncologia Medica

    Terni, TR, 06132, Italy

  • AOU Careggi

    Florence, FI, 50134, Italy

  • Aou Federico Ii - Uoc Di Oncologia Medica

    Naples, 80131, Italy

  • Ausl/Irccs Di Reggio Emilia - S.O.C. Oncologia Medica Provinciale

    Reggio Emilia, RE, 42123, Italy

  • Irccs San Raffaele - Milano

    Milan, MI, 20132, Italy

  • Istituto Romagnolo Per Lo Studio Dei Tumori "Dino Amadori" Irccs Irst

    Meldola, FC, 47014, Italy

  • Oncologia Medica Universitaria, Azienda Ospedaliera Universitaria Consorziale Policlinico Di Bari

    Bari, BA, Italy

  • POLICLINICO RIUNITI FOGGIA Oncologia Medica

    Foggia, FG, 71122, Italy

  • UOC ONCOLOGIA MEDICA IRCCS Ospedale Policlinico San Martino

    Genova, GE, 16132, Italy

  • UOC Oncologia Medica AOU di Verona

    Verona, VR, 37126, Italy

  • UOC di Oncologia Medica 2 IOV Istituto Oncologico Veneto

    Padova, PD, 35128, Italy

  • UOC di Oncologia Medica AOU Policlinico S. Orsola Malpighi

    Bologna, BO, 40138, Italy

  • Uoc Oncologia - Ospedale Di Macerata

    Province of Macerata, MC, 62100, Italy

  • Uoc Oncologia Medica A.R.Na.S.Civico Benefratelli Di Cristina

    Palermo, PA, 90127, Italy

  • Uoc Oncologia Medica Aorn Cardarelli Napoli

    Naples, 80131, Italy

  • Uoc Oncologia Medica Aou Parma

    Parma, PR, 43126, Italy

  • Uoc Oncologia Medica Fondazione Irccs Istituto Nazionale Dei Tumori

    Milan, MI, 20133, Italy

  • Uoc Oncologia Medica Fondazione Policlinico Universitario A. Gemelli Irccs

    Roma, RM, 00168, Italy

  • Uoc Oncologia Medica- Azienda Ospedaliero-Universitaria Di Modena

    Modena, MO, 41124, Italy

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