New hope for kids with Tough-to-Treat cancers
NCT ID NCT04773782
Summary
This study tested a drug called avapritinib in children and teenagers (ages 2 to 18) with advanced solid tumors, including brain tumors, that had come back or stopped responding to standard treatments. The trial aimed to find a safe dose and see if the drug could shrink tumors in patients whose cancers had specific genetic changes. All 29 participants received the drug, and researchers measured safety, how the drug moved through the body, and initial signs of effectiveness.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Ann and Robert H. Lurie Children's Hospital of Chicago
Chicago, Illinois, 60611, United States
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Asan Medical Center
Seoul, 05505, South Korea
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Children's Hospital Colorado
Aurora, Colorado, 80045, United States
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Children's Medical Center
Dallas, Texas, 75235, United States
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Columbia University Medical Center
New York, New York, 10032, United States
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Dana Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Dipartimento di Oncologia Medica ed Ematologia - S.C. Pediatria Oncologica
Milan, 20133, Italy
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Duke University Medical Center
Durham, North Carolina, 27710, United States
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Great Ormond Street Hospital For Children
London, WC1N 3JH, United Kingdom
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Gustave Roussy
Villejuif, 94805, France
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Hopp Children's Cancer Center
Heidelberg, Germany
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Medizinische Universitat Wein
Vienna, Vienna, 1090, Austria
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Nationwide Children's Hospital
Columbus, Ohio, 43205, United States
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Oregon Health and Science University
Portland, Oregon, 97239, United States
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Phoenix Children's Hospital
Phoenix, Arizona, 85016, United States
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Royal Children's Hospital
Parkville, Victoria, 3052, Australia
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Samsung Medial Center
Seoul, 06351, South Korea
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Sydney Children's Hospital, Kids Cancer Center
Sydney, New South Wales, 2031, Australia
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The Hospital for Sick Children
Toronto, Ontario, M5G1X8, Canada
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The Johns Hopkins Hospital
Baltimore, Maryland, 21287, United States
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UPMC Children's Hospital of Pittsburgh
Pittsburgh, Pennsylvania, 15224, United States
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Universitaetsmedizin Göttingen
Göttingen, Lower Saxony, 37075, Germany
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University of California San Francisco, Benioff Children's Hospital
San Francisco, California, 94518, United States
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University of Michigan
Ann Arbor, Michigan, 48109, United States
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University of Texas MD Anderson Cancer Center
Houston, Texas, 77030, United States
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Washington University School of Medicine
St Louis, Missouri, 63110, United States
Conditions
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