Personalized vaccine shows promise in High-Risk bladder cancer trial

NCT ID NCT06534983

Recruiting now Disease control Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 13, 2026 · Updated 28 times

Summary

This study tests whether adding a personalized cancer vaccine (autogene cevumeran) to an immunotherapy drug (nivolumab) can better prevent bladder cancer from coming back after surgery. About 362 people with high-risk muscle-invasive bladder cancer will take part. The approach aims to train the immune system to recognize and attack remaining cancer cells, potentially reducing the risk of recurrence.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

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Locations

A.O. Universitaria Ospedale Consorziale Policlinico Di Bari
RECRUITING

Bari, Apulia, 70124, Italy
A.O. Universitaria S. Luigi Gonzaga
RECRUITING

Orbassano, Piedmont, 10043, Italy
A.O.U di Verona Policlinico G.B. Rossi
RECRUITING

Verona, Veneto, 37134, Italy
AHN Cancer Institute ? Allegheny General Hospital
WITHDRAWN

Pittsburgh, Pennsylvania, 15212, United States
AIDPORT Sp. z o. o.
RECRUITING

Skórzewo, 60-185, Poland
AZ Groeninge
WITHDRAWN

Kortrijk, 8500, Belgium
AZ.Osp S. Orsola ? Malpighi-Reparto di Oncologia Medica
RECRUITING

Bologna, Emilia-Romagna, 40138, Italy
Aalborg Universitetshospital
RECRUITING

Aalborg, 9000, Denmark
Aarhus Universitetshospital
RECRUITING

Aarhus N, 8200, Denmark
Akershus universitetssykehus
COMPLETED

Lørenskog, 1474, Norway
Alexandras Hospital
RECRUITING

Athens, 115 28, Greece
Asan Medical Center
ACTIVE_NOT_RECRUITING

Seoul, 05505, South Korea
Asst Papa Giovanni XXIII
RECRUITING

Bergamo, Lombardy, 24127, Italy
Attikon University General Hospital
RECRUITING

Athens, 124 61, Greece
Barts & London School of Med;Medical Oncology
RECRUITING

London, EC1M 6BQ, United Kingdom
Bon Secours - St. Francis Hospital
WITHDRAWN

Greenville, South Carolina, 29607, United States
Box Hill Hospital
WITHDRAWN

Box Hill, Victoria, 3128, Australia
CUAN Hospital
WITHDRAWN

San Pedro Garza García, Nuevo León, 66278, Mexico
Centre Eugene Marquis Centre Regional de Lutte Contre Le Cancer
RECRUITING

Rennes, 35000, France
Centrum Onkologii Ziemi Lubelskiej im. sw. Jana z Dukli
WITHDRAWN

Lublin, 20-090, Poland
Centrum Onkologii im. Prof. Franciszka ?ukaszczyka
RECRUITING

Bydgoszcz, 85-796, Poland
Chang Gung Medical Foundation - Kaohsiung
RECRUITING

Kaohisung, DUMMY_VALUE, Taiwan
City of Hope Cancer Center
WITHDRAWN

Duarte, California, 91010, United States
Clatterbridge Cancer Centre
WITHDRAWN

Bebington, CH63 4JY, United Kingdom
Clinique Ste-Elisabeth
RECRUITING

Namur, 5000, Belgium
Columbia University Irving Medical Center
WITHDRAWN

New York, New York, 10032, United States
Complejo Hospitalario Universitario de Santiago (CHUS)
RECRUITING

Santiago de Compostela, LA Coruna, 15706, Spain
Cross Cancer Institute
RECRUITING

Edmonton, Alberta, T6G 1Z2, Canada
Erasmus MC
RECRUITING

Rotterdam, 3015 GD, Netherlands
Fred Hutchinson Cancer Research Center
RECRUITING

Seattle, Washington, 98109, United States
Georgetown University Medical Center Lombardi Cancer Center
WITHDRAWN

Washington D.C., District of Columbia, 20007, United States
Henry Ford Health System
WITHDRAWN

Detroit, Michigan, 48202, United States
Herlev Hospital
RECRUITING

Herlev, 2730, Denmark
Highlands Oncology Group.
RECRUITING

Springdale, Arkansas, 72762, United States
Hopital Claude Huriez
RECRUITING

Lille, 59000, France
Hospital Britanico
RECRUITING

Buenos Aires, C1280AEB, Argentina
Hospital Civil de Guadalajara Fray Antonio Alcalde
RECRUITING

Guadalajara, Jalisco, 44280, Mexico
Hospital Clinico San Carlos
RECRUITING

Madrid, 28040, Spain
Hospital Clinico Universitario Lozano Blesa
RECRUITING

Zaragoza, 50009, Spain
Hospital General Universitario de Valencia
RECRUITING

Valencia, 46014, Spain
Hospital Italiano
COMPLETED

Ciudad Autonoma Buenos Aires, C1199ABB, Argentina
Hospital Moinhos de Vento
WITHDRAWN

Porto Alegre, Rio Grande do Sul, 90035-000, Brazil
Hospital Universitario La Paz
RECRUITING

Madrid, 28046, Spain
Hospital Universitario Son Espases
RECRUITING

Palma de Mallorca, Balearic Islands, 07014, Spain
Hospital Universitario Virgen del Rocio
RECRUITING

Seville, 41013, Spain
ICO L'Hospitalet
RECRUITING

L'Hospitalet de Llobregat, Barcelona, 08908, Spain
IFO - Istituto Regina Elena
RECRUITING

Rome, Lazio, 00144, Italy
IOV - Istituto Oncologico Veneto - IRCCS
WITHDRAWN

Padova, Veneto, 35128, Italy
Inova Schar Cancer Institute
WITHDRAWN

Fairfax, Virginia, 22031, United States
Institut Gustave Roussy
RECRUITING

Villejuif, 94805, France
Institut Paoli Calmettes
WITHDRAWN

Marseille, 13273, France
Instituto Alexander Fleming
RECRUITING

Buenos Aires, 1426, Argentina
Instituto Valenciano Oncologia
RECRUITING

Valencia, 46009, Spain
Istituto Clinico Humanitas
WITHDRAWN

Rozzano, Lombardy, 20089, Italy
Istituto Nazionale Tumori Irccs Fondazione G. Pascale
WITHDRAWN

Naples, Campania, 80131, Italy
Jewish General Hospital
COMPLETED

Montreal, Quebec, H3T 1E2, Canada
Kaiser Permanente - Baldwin Park
RECRUITING

Baldwin Park, California, 91706, United States
Kaiser Permanente - Los Angeles (N. Vermont)
RECRUITING

Los Angeles, California, 90027, United States
Kaiser Permanente - Riverside
RECRUITING

Riverside, California, 92505, United States
Klinikum Stuttgart - Katharinenhospital
RECRUITING

Stuttgart, 70174, Germany
Klinikum rechts der Isar der TU München
WITHDRAWN

München, 81675, Germany
Lyell McEwin Hospital
RECRUITING

Elizabeth Vale, South Australia, 5112, Australia
MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
MSK Bergen
RECRUITING

Montvale, New Jersey, 07645, United States
MSK Commack
RECRUITING

Commack, New York, 11725, United States
MSK Monmouth
RECRUITING

Middletown, New Jersey, 07748, United States
MSK Nassau
RECRUITING

Uniondale, New York, 11553, United States
MSK Westchester
RECRUITING

Harrison, New York, 10604, United States
Marien Hospital Herne
RECRUITING

Herne, 44625, Germany
McGill University Health Center
COMPLETED

Montreal, Quebec, H4A 3J1, Canada
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
Memorial Sloan Kettering Cancer Center Basking Ridge
RECRUITING

Basking Ridge, New Jersey, 07920, United States
Narodowy Instytut Onkologii im. M. Sklodowskiej-Curie
WITHDRAWN

Warsaw, 02-781, Poland
National Taiwan Uni Hospital
WITHDRAWN

Taipei, 100, Taiwan
Norton Cancer Institute
WITHDRAWN

Louisville, Kentucky, 40207, United States
Princess Margaret Cancer Center
RECRUITING

Toronto, Ontario, M5G 1Z5, Canada
Providence Portland Medical Ctr
RECRUITING

Portland, Oregon, 97225, United States
Radomskie Centrum Onkologii
RECRUITING

Radom, 26-600, Poland
Rhode Island Hospital
WITHDRAWN

Providence, Rhode Island, 02903, United States
Royal Devon and Exeter Hospital
RECRUITING

Exeter, EX2 5DW, United Kingdom
Royal Preston Hosptial
WITHDRAWN

Preston, PR2 9HT, United Kingdom
Sahlgrenska University Hospital
RECRUITING

Gothenburg, 413 45, Sweden
Samsung Medical Center
RECRUITING

Seoul, 06351, South Korea
Seoul National University Bundang Hospital
RECRUITING

Seongnam-si, 463-707, South Korea
Seoul National University Hospital
RECRUITING

Seoul, 03080, South Korea
Severance Hospital, Yonsei University Health System
WITHDRAWN

Seoul, 03722, South Korea
Skånes Onkologiska Klinik, Universitetssjukhuset
WITHDRAWN

Lund, 22185, Sweden
Southampton General Hospital
WITHDRAWN

Southampton, SO16 6YD, United Kingdom
St. Antonius locatie Leidsche Rijn
WITHDRAWN

Utrecht, 3543 AZ, Netherlands
Sunshine Hospital
RECRUITING

St Albans, Victoria, 3021, Australia
Szpital Kliniczny Ministerstwa Spraw Wewn?trznych i Administracji z Warmi?sko-Mazurskim Centrum Onkologii w Olsztynie
RECRUITING

Olsztyn, 10-228, Poland
Szpital Wojewodzki im. M. Kopernika w Koszalinie
RECRUITING

Koszalin, 75-581, Poland
Taipei Veterans General Hospital
RECRUITING

Taipei, 112, Taiwan
Theageneio Hospital
RECRUITING

Thessaloniki, 546 39, Greece
UZ Gent
WITHDRAWN

Ghent, 9000, Belgium
UZ Leuven Gasthuisberg
WITHDRAWN

Leuven, 3000, Belgium
Uniklinik Essen
WITHDRAWN

Essen, 45122, Germany
Uniklinik-Eppendorf
WITHDRAWN

Hamburg, 20246, Germany
Uniklinikum Heidelberg
COMPLETED

Heidelberg, 69120, Germany
University of California San Francisco
RECRUITING

San Francisco, California, 94158, United States
University of Washington Medical Center
RECRUITING

Seattle, Washington, 98195, United States
Universitätsklinikum Düsseldorf;Urologische Klinik
RECRUITING

Düsseldorf, 40225, Germany
Universitätsklinikum Jena, Urologische Klinik und Poliklinik
RECRUITING

Jena, 07747, Germany
Universitätsklinikum Ulm
ACTIVE_NOT_RECRUITING

Ulm, 89081, Germany
Vall d'Hebron Institute of Oncology (VHIO), Barcelona
RECRUITING

Sant Andreu de la Barca, Barcelona, 08740, Spain
Vivantes Klinikum Am Urban
COMPLETED

Berlin, 10967, Germany
Yale Cancer Center
WITHDRAWN

New Haven, Connecticut, 06520, United States

Conditions

Explore the condition pages connected to this study.

MUSCLE-INVASIVE UROTHELIAL CARCINOMA