New knee implant system tested for tough first replacements
NCT ID NCT03153449
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study is testing the ATTUNE Revision Knee System in 400 people who need a first knee replacement but have complex bone or joint issues. The implant is normally used for revision surgeries, but here it's being used for primary cases. Researchers will track how well patients can do daily activities over 5 years.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
ATTUNE Revision Knee System (a set of knee implant components)
What this could lead to
If successful, this could show that the ATTUNE Revision System is a safe and effective option for people with complex knee anatomy needing a first knee replacement.
What could go wrong
This is an early-stage, non-randomized study without a comparison group, so results may not prove superiority over other implants. Risks include typical surgical complications like infection, implant loosening, or the need for revision surgery.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for PRIMARY KNEE ARTHROPLASTY are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
Arthroplasty Foundation
Louisville, Kentucky, 40215, United States
-
Asklepios Orthopädische Klinik Lindenlohe
Schwandorf in Bayern, Germany
-
CHRU La Cavale Blanche
Brest, France
-
Centre Hospitalier Universitaire de Rennes
Rennes, France
-
Chapel Allerton Orthopaedic Centre
Leeds, United Kingdom
-
Colorado Joint Replacement
Denver, Colorado, 80210, United States
-
Concordia Joint Replacement
Winnipeg, Canada
-
Dartmouth-Hitchcock Medical Center
Lebanon, New Hampshire, 03756, United States
-
Florida Orthopedic Associates
DeLand, Florida, 32720, United States
-
Fondren Orthopedic Group
Houston, Texas, 77030, United States
-
Fremantle Hospital
Fremantle, Australia
-
Hampshire Hospitals NHS Foundation Trust
Basingstoke, United Kingdom
-
James Cook University Hospital
Middlesbrough, United Kingdom
-
Klinik und Poliklinik für Orthopädie und Sportorthopädie am Klinikum rechts der Isar der Technischen Universität Münche
Munich, Germany
-
Krankenhaus der Barmherzigen Schwestern Linz Betriebsgesellschaft m.b.H.
Linz, Austria
-
London Health Sciences Centre University Hospital
London, Ontario, Canada
-
Nuffield Orthopaedic Centre
Oxford, United Kingdom
-
OrthoCarolina Hip and Knee Center
Charlotte, North Carolina, 28207, United States
-
Orthopaedic Center of the Rockies
Fort Collins, Colorado, 80525, United States
-
Orthopedic Partners
Niantic, Connecticut, 06357, United States
-
Rothman Institute
Egg Harbor, New Jersey, 08234, United States
-
Scripps Clinic Torrey Pines
San Diego, California, 92037, United States
-
South Infirmary Public Hospital
Cork, Ireland
-
Southern Joint Replacement Institute
Nashville, Tennessee, 37203, United States
-
St. John of God Murdoch Hospital
Perth, Australia
-
Texas Institute for Hip & Knee Surgery
Austin, Texas, 78751, United States
-
The Ohio State University Wexner Medical Center
Columbus, Ohio, 43210, United States
-
The Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Foundation Trust
Oswestry, United Kingdom
-
UNC Orthopaedics
Chapel Hill, North Carolina, 27514, United States
-
University Hospital Maastricht
Maastricht, Netherlands
-
University of Mississippi Medical Center
Jackson, Mississippi, 39216, United States
-
Victoria Hospital NHS Fife
Kirkcaldy, United Kingdom
-
Wellington Hospital
Wellington, New Zealand
-
Wrightington Hospital
Wigan, United Kingdom