New knee implant system tested for tough first replacements

NCT ID NCT03153449

Ongoing Disease control Sponsor: DePuy Orthopaedics Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 07, 2026 · Updated 2 times

Summary

This study is testing the ATTUNE Revision Knee System in 400 people who need a first knee replacement but have complex bone or joint issues. The implant is normally used for revision surgeries, but here it's being used for primary cases. Researchers will track how well patients can do daily activities over 5 years.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ATTUNE Revision Knee System (a set of knee implant components)
What this could lead to: If successful, this could show that the ATTUNE Revision System is a safe and effective option for people with complex knee anatomy needing a first knee replacement.
What could go wrong: This is an early-stage, non-randomized study without a comparison group, so results may not prove superiority over other implants. Risks include typical surgical complications like infection, implant loosening, or the need for revision surgery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Congenital Abnormalities Joint Instability

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PRIMARY KNEE ARTHROPLASTY

Contacts and locations

Locations

Arthroplasty Foundation

Louisville, Kentucky, 40215, United States
Asklepios Orthopädische Klinik Lindenlohe

Schwandorf in Bayern, Germany
CHRU La Cavale Blanche

Brest, France
Centre Hospitalier Universitaire de Rennes

Rennes, France
Chapel Allerton Orthopaedic Centre

Leeds, United Kingdom
Colorado Joint Replacement

Denver, Colorado, 80210, United States
Concordia Joint Replacement

Winnipeg, Canada
Dartmouth-Hitchcock Medical Center

Lebanon, New Hampshire, 03756, United States
Florida Orthopedic Associates

DeLand, Florida, 32720, United States
Fondren Orthopedic Group

Houston, Texas, 77030, United States
Fremantle Hospital

Fremantle, Australia
Hampshire Hospitals NHS Foundation Trust

Basingstoke, United Kingdom
James Cook University Hospital

Middlesbrough, United Kingdom
Klinik und Poliklinik für Orthopädie und Sportorthopädie am Klinikum rechts der Isar der Technischen Universität Münche

Munich, Germany
Krankenhaus der Barmherzigen Schwestern Linz Betriebsgesellschaft m.b.H.

Linz, Austria
London Health Sciences Centre University Hospital

London, Ontario, Canada
Nuffield Orthopaedic Centre

Oxford, United Kingdom
OrthoCarolina Hip and Knee Center

Charlotte, North Carolina, 28207, United States
Orthopaedic Center of the Rockies

Fort Collins, Colorado, 80525, United States
Orthopedic Partners

Niantic, Connecticut, 06357, United States
Rothman Institute

Egg Harbor, New Jersey, 08234, United States
Scripps Clinic Torrey Pines

San Diego, California, 92037, United States
South Infirmary Public Hospital

Cork, Ireland
Southern Joint Replacement Institute

Nashville, Tennessee, 37203, United States
St. John of God Murdoch Hospital

Perth, Australia
Texas Institute for Hip & Knee Surgery

Austin, Texas, 78751, United States
The Ohio State University Wexner Medical Center

Columbus, Ohio, 43210, United States
The Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Foundation Trust

Oswestry, United Kingdom
UNC Orthopaedics

Chapel Hill, North Carolina, 27514, United States
University Hospital Maastricht

Maastricht, Netherlands
University of Mississippi Medical Center

Jackson, Mississippi, 39216, United States
Victoria Hospital NHS Fife

Kirkcaldy, United Kingdom
Wellington Hospital

Wellington, New Zealand
Wrightington Hospital

Wigan, United Kingdom