Lung cancer trial: does adding a second drug boost survival?

NCT ID NCT03896074

Ongoing Disease control Sponsor: Fondazione Ricerca Traslazionale Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 2 trial compares the drug atezolizumab alone versus atezolizumab plus bevacizumab as a first treatment for people with advanced non-small-cell lung cancer that has a specific marker (PD-L1). About 206 patients are taking part. The main goal is to see if the combination helps people live longer.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

atezolizumab and bevacizumab

What this could lead to

If it works, this could point toward a more effective first-line treatment for advanced non-small-cell lung cancer.

What could go wrong

This is a Phase 2 trial with 206 participants, so results are still early. The combination may not improve survival and could add side effects like bleeding or high blood pressure from bevacizumab.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-SMALL-CELL LUNG CANCER PATIENTS

Contacts and locations

Show contact details

Locations

A.O. Per l' emergenza Cannizzaro

Catania, 95126, Italy
A.O.U. Policlinico - Vittorio Emanuele- Presidio Ospedaliero Gaspare Rodolico

Catania, CT, 95125, Italy
AO Papardo

Messina, 98158, Italy
AOU Ospedali Riuniti "Umberto I- G.M.Lancisi-G.Salesi"

Ancona, 60020, Italy
AOU S. Luigi Orbassano

Orbassano, 10043, Italy
ASST Sette Laghi

Varese, 21100, Italy
AUOI di Verona- Borgo Trento

Verona, 37126, Italy
AUSL della Romagna

Ravenna, RA, 48121, Italy
AUSL di Teramo - Ospedale "Giuseppe Mazzini"

Teramo, TE, 64100, Italy
AZIENDA USL DI PIACENZA-Ospedale Guglielmo da Saliceto

Piacenza, PC, 29121, Italy
Arcispedale Santa Maria Nuova

Reggio Emilia, 42100, Italy
Asst Di Lecco

Lecco, CM, 23900, Italy
Azienda Ospedaliera Dei Colli V.Monaldi

Naples, 80131, Italy
Azienda Ospedaliera S.Giovanni Addolorata

Roma, RM, 00184, Italy
Azienda Ospedaliera San Camillo-Forlanini

Roma, Roma, 00152, Italy
Azienda Ospedaliero-Universitaria Di Modena

Modena, MO, 41124, Italy
C.R.O.B. - I.R.C.C.S.

Rionero in Vulture, PZ, 85028, Italy
Fondazione IRCCS - San Gerardo del Tintori

Monza, MILANO, 20900, Italy
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

Milan, 20122, Italy
Fondazione PTV - POLICLINICO TOR VERGATA

Roma, RM, 00133, Italy
IRCCS ISTITUTO Oncologico Veneto

Padova, 35128, Italy
IRCCS Oncologico Istituto Tumori "Giovanni Paolo II"

Bari, 70124, Italy
IRCCS Ospedale Casa Sollievo della Sofferenza

San Giovanni Rotondo, 71013, Italy
Irccs S.R.L. Irst

Meldola, 47014, Italy
Istituto Nazionale Tumori di Napoli IRCCS Pascale

Naples, 80131, Italy
OSPEDALE SAN PAOLO - ASL Roma 4

Civitavecchia, RM, 00053, Italy
Ospedale Degli Infermi Di Biella

Ponderano, BI, 13875, Italy
Ospedale Della Misericordia

Grosseto, GR, 58100, Italy
Ospedale S.G. Moscati

Statte, TA, 74010, Italy
Ospedale Sacro Cuore- Don Calabria

Negrar, 37024, Italy
P.O. Antonio Perrino

Brindisi, 72100, Italy
P.O. Umberto I

Syracuse, SR, 96100, Italy
Presidio Ospedaliero Unico Av3 - Ospedale Generale Provinciale - Macerata

Province of Macerata, MC, 62100, Italy