New drug combo shows promise for rare bile duct cancer

NCT ID NCT05174650

First seen Jan 06, 2026 · Last updated May 11, 2026 · Updated 20 times

Summary

This study tests a combination of two drugs, atezolizumab and derazantinib, in 27 adults with advanced bile duct cancer that has a specific FGFR2 gene change. The goal is to see if the treatment can shrink tumors and control the disease. Participants receive the drugs intravenously and by mouth, and are monitored for side effects and tumor response every 8 weeks.

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Contacts and locations

Locations

  • Alexianer Krefeld GmbH

    Krefeld, Germany

  • HELIOS KLinikum Bad Saarow

    Bad Saarow, Germany

  • Johanniter Krankenhaus Bonn

    Bonn, Germany

  • Klinikum Esslingen

    Esslingen am Neckar, Germany

  • Klinikum rechts der Isar, Technische Universität München

    München, Germany

  • Krankenhaus Nordwest gGmbH

    Frankfurt, Germany

  • LMU München Großhadern

    Munich, Germany

  • MVZ am Oskar-Helene Heim Berlin

    Berlin, Germany

  • Marienhospital Wesel

    Wesel, Germany

  • Medizinische Hochschule Hannover

    Hanover, Germany

  • Uniklinikum Köln

    Cologne, Germany

  • Universitätsklinikum Leipzig

    Leipzig, Germany

  • Universitätsklinikum Tübingen

    Tübingen, Germany

  • Universitätsmedizin Berlin Charité

    Berlin, Germany

  • Universitätsmedizin Mainz

    Mainz, Germany

  • Universitätsmedizin Mannheim

    Mannheim, Germany

  • Vivantes Klinikum Berlin Friedrichshain

    Berlin, Germany

Conditions

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