Immunotherapy combo shows promise in Hard-to-Treat cervical cancer

NCT ID NCT03738228

First seen Nov 01, 2025 · Last updated Apr 30, 2026 · Updated 21 times

Summary

This early-phase trial tested whether adding the immunotherapy drug atezolizumab to standard chemoradiation could help control advanced cervical cancer that has spread to lymph nodes. Forty participants received atezolizumab before and during chemoradiotherapy. The main goal was to see if the combination boosted the immune system's ability to fight the cancer. Researchers also monitored side effects. This is not a cure, but aims to improve disease control.

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Contacts and locations

Locations

  • Augusta University Medical Center

    Augusta, Georgia, 30912, United States

  • Cleveland Clinic Foundation

    Cleveland, Ohio, 44195, United States

  • Medical College of Wisconsin

    Milwaukee, Wisconsin, 53226, United States

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10065, United States

  • Ohio State University Comprehensive Cancer Center

    Columbus, Ohio, 43210, United States

  • Roswell Park Cancer Institute

    Buffalo, New York, 14263, United States

  • Thomas Jefferson University Hospital

    Philadelphia, Pennsylvania, 19107, United States

  • UC San Diego Moores Cancer Center

    La Jolla, California, 92093, United States

  • UCHealth University of Colorado Hospital

    Aurora, Colorado, 80045, United States

  • UT Southwestern/Simmons Cancer Center-Dallas

    Dallas, Texas, 75390, United States

  • University of Alabama at Birmingham Cancer Center

    Birmingham, Alabama, 35233, United States

  • University of California Davis Comprehensive Cancer Center

    Sacramento, California, 95817, United States

  • University of Iowa/Holden Comprehensive Cancer Center

    Iowa City, Iowa, 52242, United States

  • University of Oklahoma Health Sciences Center

    Oklahoma City, Oklahoma, 73104, United States

  • University of Pittsburgh Cancer Institute (UPCI)

    Pittsburgh, Pennsylvania, 15232, United States

  • Women and Infants Hospital

    Providence, Rhode Island, 02905, United States

Conditions

Explore the condition pages connected to this study.