Pill combo could replace chemo for tough leukemia
NCT ID NCT04817241
First seen Nov 10, 2025 · Last updated May 14, 2026 · Updated 23 times
Summary
This study tests whether an all-oral combination of ASTX727 (a pill form of decitabine) plus venetoclax works as well as standard chemotherapy for younger adults (18-65) with high-risk acute myeloid leukemia (AML) that lacks a FLT3 mutation. The trial has two phases: first, finding a safe dose, then comparing the oral combo to standard chemo for event-free survival. Only 5 participants were enrolled, so results are very early.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Montefiore Medical Center - Moses Campus
The Bronx, New York, 10467, United States
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Montefiore Medical Center-Einstein Campus
The Bronx, New York, 10461, United States
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Roswell Park Cancer Institute
Buffalo, New York, 14263, United States
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University of Alabama at Birmingham Cancer Center
Birmingham, Alabama, 35233, United States
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University of Virginia Cancer Center
Charlottesville, Virginia, 22908, United States
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Vanderbilt University/Ingram Cancer Center
Nashville, Tennessee, 37232, United States
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Yale University
New Haven, Connecticut, 06520, United States
Conditions
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