New oral drug combo aims to keep High-Risk childhood leukemia at bay after transplant
NCT ID NCT07012044
First seen Jan 28, 2026 · Last updated Jun 12, 2026 · Updated 29 times
Summary
This phase 1 trial tests the safety and best dose of an oral drug called ASTX727 (a combination of cedazuridine and decitabine) given with filgrastim (a white blood cell booster) as maintenance therapy for children with high-risk acute myeloid leukemia (AML) that has returned or not responded to treatment, after they have received a stem cell transplant. The study aims to prevent the leukemia from coming back by helping the bone marrow produce healthy blood cells and killing abnormal cells. About 47 children will participate to find the safest dose and monitor side effects.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Children's Hospital of Philadelphia
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Children's Hospital of Pittsburgh of UPMC
RECRUITINGPittsburgh, Pennsylvania, 15224, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Memorial Sloan Kettering Cancer Center
RECRUITINGNew York, New York, 10065, United States
Contact
Contact Phone: •••-•••-••••
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Saint Jude Children's Research Hospital
RECRUITINGMemphis, Tennessee, 38105, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Minnesota/Masonic Cancer Center
RECRUITINGMinneapolis, Minnesota, 55455, United States
Contact
Contact Phone: •••-•••-••••
Conditions
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