New ultrasound dye could spot hidden heart defects
NCT ID NCT06938347
First seen Jun 25, 2026 · Last updated Jul 07, 2026 · Updated 4 times
Summary
This phase 3 trial tests a new contrast agent called ASI-02 against the standard agitated saline for detecting right-to-left shunts in the heart. About 300 adults with suspected shunts will receive both agents during an echocardiogram. The goal is to see if ASI-02 finds shunts more accurately and safely than the current method.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- ASI-02 (a contrast agent for ultrasound)
- What this could lead to
- If successful, ASI-02 could become a more reliable and consistent contrast agent for detecting heart defects that allow blood to bypass the lungs.
- What could go wrong
- This is a phase 3 trial, but the primary goal is diagnostic accuracy, not treatment. Even if ASI-02 works better than saline, it may not change patient outcomes or be widely adopted.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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AH Illinois Masonic Center
RECRUITINGChicago, Illinois, 60657, United States
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Aurora St. Lukes Medical Center
RECRUITINGMilwaukee, Wisconsin, 53215, United States
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CentraCare
RECRUITINGSaint Cloud, Minnesota, 56303, United States
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Jackson Heart Clinic
RECRUITINGJackson, Mississippi, 39216, United States
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Mayo Clinic
RECRUITINGRochester, Minnesota, 55905, United States
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NYU Langone Health
RECRUITINGNew York, New York, 10016, United States
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Northwestern University
RECRUITINGChicago, Illinois, 60611, United States
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Toronto General
RECRUITINGToronto, M5G 2C4, Canada
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