New CAR-T therapy aims to tackle Hard-to-Treat multiple myeloma

NCT ID NCT06615479

Recruiting now Disease control Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 24, 2026 · Updated 3 times

Summary

This phase 3 trial is testing a new CAR-T cell therapy called arlo-cel against standard treatments for adults with multiple myeloma that has come back or stopped responding to previous therapies. About 440 participants will receive either arlo-cel or a standard regimen. The study will compare how long the cancer stays under control and how well patients respond.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: arlocabtagene autoleucel (arlo-cel), a CAR-T cell therapy targeting GPRC5D
What this could lead to: If successful, this could offer a more effective treatment option for people with multiple myeloma that has returned or not responded to prior therapies.
What could go wrong: This is an early-phase 3 trial, so results are not yet confirmed. CAR-T therapies can cause serious side effects like cytokine release syndrome and neurological problems.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for RELAPSED OR REFRACTORY MULTIPLE MYELOMA (RRMM) are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

plasma cell myeloma Recurrence refractory plasma cell neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RELAPSED OR REFRACTORY MULTIPLE MYELOMA (RRMM)

Contacts and locations

Locations

A. C. Camargo Cancer Center
RECRUITING

São Paulo, São Paulo, 01509-010, Brazil
Aarhus Universitetshospital, Skejby
RECRUITING

Aarhus, Central Jutland, 8200, Denmark
Addenbrooke's Hospital
RECRUITING

Cambridge, Cambridgeshire, CB2 2QQ, United Kingdom
Amsterdam UMC, locatie VUmc
RECRUITING

Amsterdam, North Holland, 1081 HV, Netherlands
Antwerp University Hospital
RECRUITING

Edegem, Antwerpen, 2650, Belgium
Arthur J.E. Child Comprehensive Cancer Centre
RECRUITING

Calgary, Alberta, T2N 5G2, Canada
Asan Medical Center
RECRUITING

Seoul, Seoul-teukbyeolsi [Seoul], 05505, South Korea
Attikon General University Hospital
RECRUITING

Chaïdári, Attikí, 12462, Greece
Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino
RECRUITING

Turin, Piedmont, 10126, Italy
Baptist MD Anderson Cancer Center
RECRUITING

Jacksonville, Florida, 32207, United States
Boston Medical Center
RECRUITING

Boston, Massachusetts, 02118, United States
CHUS - Hospital Clinico Universitario
RECRUITING

Santiago de Compostela, A Coruña [La Coruña], 15706, Spain
CIUSSS de l'Est-de-l'Île-de-Montréal
RECRUITING

Montreal, Quebec, H1T 2M4, Canada
Cantonal Hospital St.Gallen
RECRUITING

Sankt Gallen, Canton of St. Gallen, 9007, Switzerland
Centre Hospitalier Lyon Sud
RECRUITING

Pierre-Bénite, Rhône, 69310, France
Centre Hospitalier Universitaire de Nantes - L' Hopital l'hôtel-Dieu
RECRUITING

Nantes, Pays de la Loire Region, 44000, France
Centrum Onkologii Ziemi Lubelskiej
RECRUITING

Lublin, Lublin Voivodeship, 20-090, Poland
Charité Campus Virchow-Klinikum
RECRUITING

Berlin, 13353, Germany
China Medical University Hospital
RECRUITING

Taichung, 404332, Taiwan
Churchill Hospital
RECRUITING

Oxford, Oxfordshire, OX3 7LE, United Kingdom
Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States
Clinica Universidad de Navarra
RECRUITING

Pamplona, Navarre, 31008, Spain
Cliniques universitaires Saint-Luc
RECRUITING

Brussels, Bruxelles-Capitale, Région de, 1200, Belgium
Debreceni Egyetem Klinikai Kozpont
RECRUITING

Debrecen, Hajdú-Bihar, 4032, Hungary
Dr. Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastırma Hastanesi
RECRUITING

Ankara, 06200, Turkey (Türkiye)
Evangelismos General Hospital of Athens
RECRUITING

Athens, Attikí, 106 76, Greece
Fakultni nemocnice Hradec Kralove
RECRUITING

Hradec Králové, Hradec Králové, 500 05, Czechia
Fakultni nemocnice Ostrava
RECRUITING

Ostrava, Moravian-Silesian Region, 708 52, Czechia
Fakultní nemocnice Brno Bohunice
RECRUITING

Brno, Brno-město, 625 00, Czechia
Fiona Stanley Hospital
RECRUITING

Murdoch, Western Australia, 6150, Australia
Fondazione IRCCS Istituto Nazionale dei Tumori
RECRUITING

Milan, Lombardy, 20133, Italy
Fox Chase Cancer Center
RECRUITING

Philadelphia, Pennsylvania, 19111, United States
Freeman Hospital
RECRUITING

Newcastle upon Tyne, NE7 7DN, United Kingdom
Fundeni Clinical Institute
RECRUITING

Bucharest, Bucharest, 022328, Romania
Hadassah Medical Center
RECRUITING

Jerusalem, Jerusalem, 9112001, Israel
Hanusch-Krankenhaus
RECRUITING

Vienna, 1140, Austria
Helsinki University Hospital - Comprehensive Cancer Center (HYKS - Syöpäkeskus)
RECRUITING

Helsinki, Uusimaa, 00029, Finland
Henri Mondor Hospital
RECRUITING

Créteil, Val-de-Marne, 94010, France
Hopital Claude Huriez - CHU de Lille
RECRUITING

Lille, Nord, 59000, France
Hospital Aleman
RECRUITING

Buenos Aires, Buenos Aires F.D., C1118AAT, Argentina
Hospital Italiano de Buenos Aires
RECRUITING

ABB, Buenos Aires F.D., C1199ABB, Argentina
Hospital Universitari Son Espases
RECRUITING

Palma, Balears [Baleares], 07120, Spain
Hospital Universitario Virgen Nieves
RECRUITING

Granada, 18012, Spain
Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca
RECRUITING

Salamanca, 37007, Spain
Huntsman Cancer Institute
RECRUITING

Salt Lake City, Utah, 84112, United States
Hyogo Medical University Hospital
RECRUITING

Nishinomiya, Hyōgo, 663-8501, Japan
Hôpital Saint-Louis
RECRUITING

Paris, 75010, France
IRCCS AOM Azienda Ospedaliera Metropolitana
RECRUITING

Genova, 16132, Italy
IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola
RECRUITING

Bologna, 40138, Italy
Inselspital Bern
RECRUITING

Bern, Canton of Bern, 3010, Switzerland
Institut Catalan d Oncologia (ICO) - Badalona
RECRUITING

Badalona, Barcelona [Barcelona], 08916, Spain
Instituto D'Or de Pesquisa e Ensino (IDOR)
RECRUITING

São Paulo, 01401-002, Brazil
Instituto Português de Oncologia do Porto Francisco Gentil, EPE
RECRUITING

Porto, 4200-072, Portugal
Institutul Regional de Oncologie
RECRUITING

Iași, 700483, Romania
Istituto Clinico Humanitas
RECRUITING

Rozzano, Milano, 20089, Italy
Japanese Red Cross Medical Center
RECRUITING

Shibuya-ku, Tokyo, 150-8935, Japan
Kanazawa University Hospital
RECRUITING

Kanazawa, Ishikawa-ken, 920-8641, Japan
Karolinska Universitetssjukhuset Huddinge
RECRUITING

Huddinge, 141 86, Sweden
Klinikum Chemnitz - Flemmingstraße
RECRUITING

Chemnitz, Saxony, 09116, Germany
Klinikum Nuernberg Nord
RECRUITING

Nuremberg, 90419, Germany
Kumamoto University Hospital
RECRUITING

Kumamoto, 860-8556, Japan
Kyushu University Hospital
RECRUITING

Fukuoka, 812-8582, Japan
Levine Cancer Institute
RECRUITING

Charlotte, North Carolina, 28204, United States
Levine Cancer Institute
RECRUITING

Charlotte, North Carolina, 28204, United States
Liverpool Hospital
RECRUITING

Liverpool, New South Wales, 2170, Australia
Local Institution - 0012
NOT_YET_RECRUITING

Nova Lima, Minas Gerais, 34000-000, Brazil
Local Institution - 0084
NOT_YET_RECRUITING

Katowice, 40-519, Poland
Local Institution - 0125
NOT_YET_RECRUITING

Budapest, 1097, Hungary
Local Institution - 0178
NOT_YET_RECRUITING

Riyadh, 12713, Saudi Arabia
Local Institution - 0181
WITHDRAWN

Singapore, Central Singapore, 169608, Singapore
Local Institution - 0192
NOT_YET_RECRUITING

Hamilton, Ontario, L8V5C2, Canada
Local Institution - 0214
WITHDRAWN

ABB, Buenos Aires F.D., C1199ABB, Argentina
Local Institution - 0219
WITHDRAWN

Minneapolis, Minnesota, 55455, United States
Local Institution - 0221
NOT_YET_RECRUITING

Stony Brook, New York, 11794, United States
Local Institution - 0223
NOT_YET_RECRUITING

Washington D.C., District of Columbia, 20007, United States
Local Institution - 0227
NOT_YET_RECRUITING

Charleston, South Carolina, 29425, United States
Local Institution - 0228
WITHDRAWN

Orlando, Florida, 32804, United States
Local Institution - 0232
NOT_YET_RECRUITING

Pittsburgh, Pennsylvania, 15224, United States
Louisiana State University Health Sciences Shreveport
RECRUITING

Shreveport, Louisiana, 71103, United States
Maastricht UMC+
RECRUITING

Maastricht, Limburg, 6229 HX, Netherlands
Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Medizinische Hochschule Hannover
RECRUITING

Hanover, Lower Saxony, 30625, Germany
Monash Health
RECRUITING

Clayton, Victoria, 3168, Australia
Nagoya City University Hospital
RECRUITING

Nagoya, Aichi-ken, 467-8602, Japan
National Cancer Center Hospital East
RECRUITING

Kashiwa, Chiba, 277-8577, Japan
National Hospital Organization Okayama Medical Center
RECRUITING

Okayama, 701-1192, Japan
National Taiwan University Cancer Center (NTUCC)
RECRUITING

Taipei City, Taipei, 106, Taiwan
National Taiwan University Hospital
RECRUITING

Taipei, 10002, Taiwan
National University Hospital
RECRUITING

Singapore, Central Singapore, 119074, Singapore
Odense Universitetshospital
RECRUITING

Odense, Region Syddanmark, 5000, Denmark
Ordensklinikum Linz GmbH Elisabethinen
RECRUITING

Linz, Upper Austria, 4020, Austria
Osaka Red Cross Hospital
RECRUITING

Osaka, 543-8555, Japan
Oulun yliopistollinen sairaala
RECRUITING

Oulu, 90220, Finland
P.O. "S. Maria della Misericordia" Azienda Sanitaria Universitaria Friuli Centrale
RECRUITING

Udine, 33100, Italy
Peter MacCallum Cancer Centre
RECRUITING

Melbourne, Victoria, 3000, Australia
Princess Alexandra Hospital
RECRUITING

Brisbane, Queensland, 4102, Australia
QEII Health Sciences Centre - Victoria General Site
RECRUITING

Halifax, Nova Scotia, B3H 2Y9, Canada
Radboudumc
RECRUITING

Nijmegen, Gelderland, 6525 GA, Netherlands
Rigshospitalet
RECRUITING

Copenhagen, Capital Region, 2100, Denmark
Roskilde Sygehus
RECRUITING

Roskilde, Region Sjælland, 4000, Denmark
Royal Adelaide Hospital
RECRUITING

Adelaide, South Australia, 5000, Australia
Royal Prince Alfred Hospital
RECRUITING

Camperdown, New South Wales, 2050, Australia
Sahlgrenska Universitetssjukhuset
RECRUITING

Gothenburg, Västra Götalands Län [se-14], 413 45, Sweden
Samsung Medical Center
RECRUITING

Seoul, Seoul-teukbyeolsi [Seoul], 06351, South Korea
Seoul National University Hospital
RECRUITING

Seoul, Seoul-teukbyeolsi [Seoul], 03080, South Korea
Sheba Medical Center
RECRUITING

Ramat Gan, Central District, 5262100, Israel
Sheffield Teaching Hospitals NHS Foundation Trust
RECRUITING

Sheffield, S10 2JF, United Kingdom
Skånes Universitetssjukhus Lund
RECRUITING

Lund, 222 42, Sweden
Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein
RECRUITING

São Paulo, 05652-900, Brazil
Sourasky Medical Center
RECRUITING

Tel Aviv, Tell Abīb, 6423906, Israel
Spitalul Universitar de Urgență București
RECRUITING

Bucharest, 050098, Romania
Sykehusapoteket Ull
RECRUITING

Oslo, 0450, Norway
TUM Klinikum
RECRUITING

Munich, Bavaria, 81675, Germany
Taipei Veterans General Hospital
RECRUITING

Taipei, 11217, Taiwan
The Alfred Hospital
RECRUITING

Melbourne, Victoria, 3004, Australia
The Catholic Univ. of Korea Seoul St. Mary's Hospital
RECRUITING

Seoul, Seoul-teukbyeolsi [Seoul], 06591, South Korea
The Christie NHS Foundation Trust
RECRUITING

Manchester, M20 4BX, United Kingdom
Turku University Hospital
RECRUITING

Turku, 20251, Finland
UCLA Hematology/Oncology - Santa Monica
RECRUITING

Los Angeles, California, 90404, United States
UZ Gent
RECRUITING

Ghent, Oost-Vlaanderen, 9000, Belgium
Universitaetsklinikum Hamburg-Eppendorf
RECRUITING

Hamburg, 20246, Germany
Universitaetsklinikum Heidelberg
RECRUITING

Heidelberg, D-69120, Germany
Universitaetsklinikum Magdeburg
RECRUITING

Magdeburg, Saxony-Anhalt, 39120, Germany
Universitaetsklinikum Schleswig-Holstein Campus Kiel
RECRUITING

Kiel, Schleswig-Holstein, 24105, Germany
Universitaetsklinikum Wuerzburg
RECRUITING

Würzburg, 97080, Germany
Universitair Medisch Centrum Utrecht
RECRUITING

Utrecht, 3584 CX, Netherlands
University College London Hospital
RECRUITING

London, London, City of, NW1 2PG, United Kingdom
University Hospital of Patras
RECRUITING

Pátrai, Achaḯa, 26504, Greece
University of Alabama at Birmingham
RECRUITING

Birmingham, Alabama, 35205, United States
University of California, Irvine (UCI) Health - UC Irvine Medical Center
RECRUITING

Orange, California, 92868, United States
University of Miami Hospital and Clinics, Sylvester Cancer Center
RECRUITING

Miami, Florida, 33136, United States
University of Texas MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Universitätsklinikum Leipzig
RECRUITING

Leipzig, Saxony, 04103, Germany
Université Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant-Godinne - Site Godinne
RECRUITING

Yvoir, Namur, 5530, Belgium
Uniwersyteckie Centrum Kliniczne
RECRUITING

Gdansk, Pomeranian Voivodeship, 80-214, Poland
Vancouver General Hospital
RECRUITING

Vancouver, British Columbia, V5Z 1M9, Canada
Vseobecna fakultni nemocnice v Praze
RECRUITING

Prague, 12808, Czechia
Weill Cornell Medical College
RECRUITING

New York, New York, 10065, United States
Winship Cancer Institute, Emory University
RECRUITING

Atlanta, Georgia, 30322, United States
Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika w Lodzi
RECRUITING

Lodz, Łódź Voivodeship, 93-513, Poland
Yamagata University Hospital
RECRUITING

Yamagata, 990-9585, Japan

More trials for these conditions

Other studies related to the condition(s) this trial covers.