Can a single dose predict autism treatment success?

NCT ID NCT07655115

Recruiting now Symptom relief Sponsor: Hospital General Universitario Gregorio Marañon Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether the drug arbaclofen can improve social function, anxiety, and quality of life in children and adolescents with autism. Participants first receive a single dose of arbaclofen or placebo to see if brain-wave changes can predict who will benefit. Then everyone gets arbaclofen for 10 weeks to measure real-world effects. The trial involves 103 participants aged 5–17 who have already taken part in a related study.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: arbaclofen
What this could lead to: If it works, this could point toward a treatment that eases social anxiety and improves quality of life for some children with autism.
What could go wrong: This is still an early-stage test of how well a single dose predicts longer-term response. The main trial is small (103 participants) and may not show clear benefits for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

autism spectrum disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AUTISM SPECTRUM DISORDERS

Contacts and locations

Locations

Assistance Publique Hopitaux De Paris
RECRUITING

Paris, 75019, France
Complejo Asistencial De Zamora Hospital Provincial De Zamora
RECRUITING

Zamora, 49020, Spain
Hospital Clinic De Barcelona
RECRUITING

Barcelona, 08036, Spain
Hospital General Universitario Gregorio Marañón
RECRUITING

Madrid, 28007, Spain
Hospital Universitario De Salamanca
RECRUITING

Salamanca, Spain

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