New hope for tough blood cancers? early trial launches

NCT ID NCT06372717

Recruiting now Disease control Sponsor: Apollo Therapeutics Ltd Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-stage study tests an experimental drug called APL-4098, alone or with standard treatments, in adults with acute myeloid leukemia (AML) or related blood disorders. The goal is to find a safe dose and see if it shrinks cancer. About 100 people will take part.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: APL-4098 (an experimental oral drug)
What this could lead to: If successful, this could lead to a new treatment option for people with hard-to-treat AML or MDS.
What could go wrong: This is a very early Phase 1 trial with only 100 participants, so the drug may not prove effective or safe. Side effects are unknown and could be serious.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute myeloid leukemia GATA2 Deficiency myelodysplastic syndrome with excess blasts

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE MYELOID LEUKEMIA (AML) ACUTE MYELOID LEUKEMIA REFRACTORY ACUTE MYELOID LEUKEMIA, IN RELAPSE MYELODYSPLASTIC SYNDROME WITH EXCESS BLASTS MYELODYSPLASTIC SYNDROME/ACUTE MYELOID LEUKEMIA

Contacts and locations

Locations

Beatson West of Scotland Cancer Centre
RECRUITING

Glasgow, G120YN, United Kingdom
Hollywood Private Hospital
ACTIVE_NOT_RECRUITING

Nedlands, Western Australia, 6009, Australia
Monash Health
RECRUITING

Clayton, Victoria, 3168, Australia
Royal Perth Hospital
RECRUITING

Perth, Western Australia, 6000, Australia
Sarah Cannon Research Institute UK
RECRUITING

London, W1G 0PU, United Kingdom
St. Vincent's Hospital Melbourne
RECRUITING

Fitzroy, Victoria, 3065, Australia
The Alfred Hospital
RECRUITING

Melbourne, Victoria, 3004, Australia
The Royal Marsden Hospital
RECRUITING

London, SM2 5PT, United Kingdom
University Hospital of Wales
RECRUITING

Cardiff, CF14 4XW, United Kingdom

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