New pill takes on Hard-to-Treat blood cancers

NCT ID NCT07424833

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-stage trial tests a daily pill called APG-3288 in 180 adults with blood cancers like leukemia or lymphoma that have come back or not responded to standard treatments. The main goals are to find the safest dose and check for side effects. Researchers will also look for any signs that the drug is shrinking tumors.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

APG-3288

What this could lead to

If this trial succeeds, it could point toward a new treatment option for people with blood cancers that have not responded to other therapies.

What could go wrong

This is a very early Phase 1 study, so the main goal is safety, not effectiveness. The drug may not work or could cause serious side effects. It will take years before any potential treatment is available.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

chronic lymphocytic leukemia/small lymphocytic lymphoma diffuse large B-cell lymphoma follicular lymphoma hematopoietic and lymphoid system neoplasm Lymphoma, B-Cell, Marginal Zone mantle cell lymphoma marginal zone lymphoma Recurrence refractory hematologic cancer relapsed/refractory diffuse large B-cell lymphoma Waldenstrom macroglobulinemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Henan Cancer Hospital

    Zhengzhou, Henan, China

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Mayo Clinic

    Jacksonville, Florida, 32224, United States