New drug combo targets tough staph blood infections

NCT ID NCT05184764

First seen Nov 01, 2025 · Last updated May 15, 2026 · Updated 22 times

Summary

This study tested a new medicine called AP-SA02, given alongside standard antibiotics, for adults with a serious Staphylococcus aureus bloodstream infection. The main goal was to check if the combination is safe and tolerable. Fifty-six hospitalized adults took part, and researchers monitored side effects and signs of improvement over 12 days.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Banner University Medical Center

    Tucson, Arizona, 85719, United States

  • Emory University Hospital Midtown

    Atlanta, Georgia, 30308, United States

  • Froedtert Hospital and the Medical College of Wisconsin

    Milwaukee, Wisconsin, 53226, United States

  • Henry Ford Health System

    Detroit, Michigan, 48202, United States

  • Icahn School of Medicine at Mount Sinai

    New York, New York, 10029, United States

  • Johns Hopkins University

    Baltimore, Maryland, 21218, United States

  • Lundquist Institute for Biomedical Innovation at Harbor UCLA Medical Center

    Torrance, California, 90502, United States

  • Methodist Hospital Research Institute - Houston

    Houston, Texas, 77030, United States

  • Monash Health

    Clayton, Australia

  • Montefiore Medical Center

    The Bronx, New York, 10467, United States

  • Regional One Healthcare

    Memphis, Tennessee, 38103, United States

  • Rhode Island Hospital

    Providence, Rhode Island, 02903, United States

  • Rocky Mountain Regional VA Medical Center

    Aurora, Colorado, 80045, United States

  • Royal Adelaide Hospital

    Adelaide, Australia

  • Royal Melbourne Hospital

    Melbourne, Australia

  • The Alfred Hospital

    Melbourne, Australia

  • The Jamaica Hospital Medical Center

    Jamaica, New York, 11418, United States

  • Tufts Medical Center

    Boston, Massachusetts, 02111, United States

  • University of California, Los Angeles (UCLA) - Medical Center

    Los Angeles, California, 90095, United States

  • University of California, San Diego (UCSD) - Medical Center

    La Jolla, California, 92037, United States

  • University of Florida (UF) - Division of Infectious Disease

    Gainesville, Florida, 32610, United States

  • University of Florida - Jacksonville

    Jacksonville, Florida, 32209, United States

  • University of Michigan

    Ann Arbor, Michigan, 48103, United States

  • University of North Carolina - Chapel Hill School of Medicine

    Chapel Hill, North Carolina, 27599, United States

  • University of South Florida

    Tampa, Florida, 33620, United States

  • University of Southern California Keck School of Medicine

    Los Angeles, California, 90033, United States

  • Wake Forest University Health Sciences

    Winston-Salem, North Carolina, 27157, United States

  • Westmead Hospital

    Westmead, Australia

Conditions

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