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New drug could help heart surgery patients who Don't respond to standard blood thinner

NCT ID NCT06096116

Recruiting now Disease control Sponsor: Octapharma Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a drug called Atenativ, made from human plasma, in 120 adults who are resistant to heparin during planned heart surgery. Heparin is a blood thinner used to prevent clots during surgery, but some patients don't respond well. The drug aims to restore heparin's effectiveness, reducing the need for additional treatments like frozen plasma. The trial is double-blind and placebo-controlled, meaning neither patients nor doctors know who gets the real drug.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

human plasma-derived antithrombin (Atenativ)

What this could lead to

If it works, this could provide a standard treatment for heparin resistance during cardiac surgery, reducing the need for additional blood products and improving surgical safety.

What could go wrong

This is a Phase 3 trial, but with only 120 participants, results may not apply to all patients. The treatment is derived from human plasma, which carries a small risk of allergic reactions or infection transmission.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

hereditary antithrombin deficiency

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACQUIRED ANTITHROMBIN DEFICIENCY

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Atrium Health Wake Forest Baptist

    RECRUITING

    Winston-Salem, North Carolina, 27157, United States

  • CHU de Reims, Hôpital Robert Debré

    TERMINATED

    Reims, France

  • CHU de Rennes

    WITHDRAWN

    Rennes, France

  • Center of Cardiovascular and Transplant Surgery

    RECRUITING

    Brno, Czechia

  • Cleveland Clinic

    NOT_YET_RECRUITING

    Cleveland, Ohio, 44195, United States

  • Duke University Medical Center

    RECRUITING

    Durham, North Carolina, 27710-1000, United States

  • Hospital of Lithuanian university of Health sciences Kauno Klinikos

    RECRUITING

    Kaunas, Lithuania

  • Institute for Cardiovascular Diseases C.C. Iliescu

    RECRUITING

    Bucharest, Romania

  • Institute for Clinical and Experimental Medicine

    RECRUITING

    Prague, Czechia

  • Institute of Cardiovascular Diseases Vojvodina

    NOT_YET_RECRUITING

    Kamenitz, Serbia

  • Kingston Health Sciences Centre

    RECRUITING

    Kingston, Ontario, K7L2V7, Canada

  • Massachusetts General Hospital

    RECRUITING

    Boston, Massachusetts, 02114, United States

  • Montreal Heart Institute

    RECRUITING

    Montreal, Quebec, H1T1C8, Canada

  • OU Health University of Oklahoma Medical Center

    RECRUITING

    Oklahoma City, Oklahoma, 73104, United States

  • Royal Columbian Hospital

    RECRUITING

    New Westminster, British Columbia, V3L0A4, Canada

  • Royal Papworth Hospital

    RECRUITING

    Cambridge, United Kingdom

  • Stanford University School of Medicine

    RECRUITING

    Stanford, California, 94305-5101, United States

  • The James Cook University Hospital

    RECRUITING

    Middlesbrough, United Kingdom

  • The Ohio State University

    RECRUITING

    Columbus, Ohio, 43214, United States

  • Toronto General Hospital

    RECRUITING

    Toronto, Ontario, M5G2C4, Canada

  • University Hospital Coventry and Warwickshire

    RECRUITING

    Coventry, United Kingdom

  • University Hospital Innsbruck

    RECRUITING

    Innsbruck, Austria

  • University Medical Centre Ljubljana

    RECRUITING

    Ljubljana, Slovenia

  • University of Miami

    RECRUITING

    Miami, Florida, 33136, United States

  • University of Texas Southwestern Medical Center

    RECRUITING

    Dallas, Texas, 75390, United States

  • Vienna General Hospital AKH, Medical University of Vienna

    RECRUITING

    Vienna, Austria

  • Vilnius University hospital Santaros Klinikos

    RECRUITING

    Vilnius, Lithuania