New hope for advanced anal cancer: major trial tests Immune-Boosting drug

NCT ID NCT04472429

Summary

This large, completed Phase 3 trial tested whether adding a new immunotherapy drug (retifanlimab) to standard chemotherapy could better control advanced anal cancer that cannot be removed by surgery. The study involved 308 adults worldwide who had not received prior chemotherapy for their advanced disease. Participants were randomly assigned to receive either the real immunotherapy drug or a placebo (dummy drug) along with their chemotherapy, and researchers measured how long the cancer was kept from growing and how long patients lived.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Addenbrooke'S Hospital

    Cambridge, CB2 0QQ, United Kingdom

  • Aichi Cancer Center Hospital

    Nagoya, 464-8681, Japan

  • Asklepios Klinik Altona

    Hamburg, 22763, Germany

  • Azienda Ospedaliera Universitaria University Degli Studi Della Campania Luigi Vanvitelli

    Napoli, 80131, Italy

  • Azienda Ospedaliero Universitaria Ospedali Riuniti

    Torrette, 60020, Italy

  • Azienda Ospedaliero Universitaria Pisana

    Pisa, 56126, Italy

  • Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda

    Milan, 20162, Italy

  • Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda

    Milan, 20162, Italy

  • Baylor Scott and White Research Institute

    Dallas, Texas, 75246, United States

  • Blue Ridge Cancer Care

    Roanoke, Virginia, 24014, United States

  • Castle Hill Hospital

    Hull, HU16 5JQ, United Kingdom

  • Center Hospital of the National Center For Global Health and Medicine

    Shinjuku-ku, 162-8655, Japan

  • Centre Antoine Laccassagne

    Nice, 06200, France

  • Centre Hospitalier Universitaire de Bordeaux

    Bordeaux, 33075, France

  • Centre Leon Berard

    Lyon, 69008, France

  • Centre de Lutte Contre Le Cancer - Institut de Cancerologie de L'Ouest - Rene Gauducheau

    Saint-Herblain, 44800, France

  • Chu Besancon Hospital Jean Minjoz

    Besançon, 25030, France

  • Chu Hopital de La Timone

    Marseille, 13385, France

  • Chu Toulouse Hopital Rangueil

    Toulouse, 31059, France

  • Chu de Rennes - Hospital Pontchaillou

    Rennes, 35033, France

  • Churchill Hospital

    Oxford, OX3 7LE, United Kingdom

  • City of Hope National Medical Center

    Duarte, California, 91010, United States

  • Comitato Etico Fondazione Irccs Istituto Nazionale Dei Tumori Milano

    Milan, 20133, Italy

  • Complejo Hospitalario Universitario A Coruna

    A Coruña, 15006, Spain

  • European Institute of Oncology

    Milan, 20141, Italy

  • Flinders Medical Centre

    Bedford Park, South Australia, 5042, Australia

  • Fondazione Irccs Ca Granda Ospedale Maggiore

    Milan, 20122, Italy

  • Haukeland University Hospital

    Bergen, 05021, Norway

  • Herlev Og Gentofte Hospital

    Herlev, 02730, Denmark

  • Hopital Charles Nicolle Chu Rouen Hospital de Bois-Guillaume

    Rouen, 76031, France

  • Hospital Clinic de Barcelona

    Barcelona, 08036, Spain

  • Hospital General Universitario Vall D Hebron

    Barcelona, 08035, Spain

  • Hospital Universitaire Pitie-Salpetriere

    Paris, 75651, France

  • Hospital Universitario 12 de Octubre

    Madrid, 28041, Spain

  • Hospital Universitario Miguel Servet

    Zaragoza, 50009, Spain

  • Hospital Universitario Virgen Del Rocio

    Seville, 41013, Spain

  • Hospital Universitario de La Paz

    Madrid, 28046, Spain

  • Hospital de La Miletrie

    Poitiers, 86021, France

  • I.R.C.C.S. Casa Sollievo Della Sofferenza

    San Giovanni Rotondo, 71013, Italy

  • Institut Du Cancer de Montpellier

    Montpellier, 34298, France

  • Institut Gustave Roussy

    Villejuif, 94805, France

  • Institut de Cancerologie de L Ouest - Site Paul Papin

    Angers, 49055, France

  • Institut de Cancerologie de Strasbourg

    Strasbourg, 67200, France

  • Iov - Istituto Oncologico Veneto Irccs

    Padua, 35128, Italy

  • Kyushu University Hospital

    Fukuoka, 812-8582, Japan

  • Leeds Teaching Hospital

    Leeds, LS 9 7TF, United Kingdom

  • Maryland Oncology Hematology, P.A.

    Columbia, Maryland, 21044, United States

  • Mayo Clinic

    Rochester, Minnesota, 55905, United States

  • Monash Medical Centre Clayton

    Clayton, Victoria, 03168, Australia

  • National Cancer Center Hospital

    Chūōku, 104-0045, Japan

  • Ochsner Clinic

    New Orleans, Louisiana, 70121, United States

  • Osaka International Cancer Institute

    Osaka, 541-8567, Japan

  • Oslo Universitetssykehus

    Oslo, 00450, Norway

  • Ospedale Degli Infermi

    Rimini, 47923, Italy

  • Panoncology Trials Pan American Center For Oncology Trials, Llc

    San Juan, 00935, Puerto Rico

  • Princess Alexandra Hospital Australia

    Woolloongabba, Queensland, 04102, Australia

  • Renovatio Clinical Consultants Llc

    The Woodlands, Texas, 77380, United States

  • Rocky Mountain Cancer Center

    Denver, Colorado, 80218, United States

  • Royal Cornwall Hospital Truro Sunrise Centre

    Truro, TR1 3LQ, United Kingdom

  • Royal Free London Nhs Foundation Trust

    London, NW3 2QG, United Kingdom

  • Royal Preston Hospital

    Preston, PR2 9HT, United Kingdom

  • Royal Surrey County Hospital

    Guildford, GU2 7XX, United Kingdom

  • Royal Sussex County Hospital

    Brighton, BN2 5BE, United Kingdom

  • Sahlgrenska University Hospital

    Gothenburg, 413 45, Sweden

  • Saitama Medical University International Medical Center

    Hidaka-shi, 350-1298, Japan

  • Sansum Clinic

    Santa Barbara, California, 93105, United States

  • Skaenes Universitetssjukhus Lund

    Lund, 22185, Sweden

  • Son Espases University Hospital

    Palma de Mallorca, 07120, Spain

  • Stockholm South General Hospital Sodersjukhuset

    Stockholm, 118 83, Sweden

  • Texas Oncology

    Austin, Texas, 78745, United States

  • Texas Oncology-Wichita Falls Texoma Cancer Center

    Wichita Falls, Texas, 76310, United States

  • The Christie Nhs Foundation Trust Uk

    Manchester, M20 4BV, United Kingdom

  • The Royal Marsden Nhs Foundation Trust - Chelsea

    London, SW3 6JJ, United Kingdom

  • The Royal Marsden Nhs Foundation Trust - Sutton

    Sutton, SM2 5PT, United Kingdom

  • The University of Arizona Cancer Center

    Tucson, Arizona, 85724, United States

  • Tohoku University Hospital

    Sendai, 980-8574, Japan

  • UC Davis Comprehensive Cancer Center

    Sacramento, California, 95817, United States

  • Ulb Hospital Erasme

    Brussels, 01070, Belgium

  • Universitatsklinikum Bonn Aoer

    Bonn, 53127, Germany

  • University Clinic Carl Gustav Carus Technical University Dresden

    Dresden, 01307, Germany

  • University Di Cagliari-Presidio Policlinico Monserrato

    Monserrato, 09042, Italy

  • Vejle Hospital

    Vejle, 07100, Denmark

  • Virginia Cancer Specialists, Pc

    Arlington, Virginia, 22205, United States

  • Zna Middelheim

    Antwerp, 02020, Belgium

Conditions

Explore the condition pages connected to this study.