Brain gene therapy trial offers hope for untreatable epilepsy
NCT ID NCT06063850
Summary
This first-in-human study is testing whether a new gene therapy called AMT-260 can safely reduce seizures in adults with drug-resistant temporal lobe epilepsy. All 12 participants will receive a single dose delivered directly to the brain using advanced MRI guidance, without removing brain tissue. Researchers will monitor participants for one year to check safety and see if seizure frequency decreases compared to before treatment.
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Contacts and locations
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Study contacts
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Contact
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Allegheny Health Network
RECRUITINGPittsburgh, Pennsylvania, 15212, United States
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Baylor Scott & White Medical Center
RECRUITINGAustin, Texas, 78735, United States
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Cleveland Clinic
RECRUITINGCleveland, Ohio, 44195, United States
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Corewell Health
RECRUITINGGrand Rapids, Michigan, 49503, United States
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Dartmouth Hitchcock Medical Center
RECRUITINGLebanon, New Hampshire, 03756, United States
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Hospital of the University of Pennsylvania
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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Johns Hopkins School of Medicine
RECRUITINGBaltimore, Maryland, 21287, United States
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Kansas University Medical Center
RECRUITINGKansas City, Kansas, 66160, United States
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Massachusetts General Hospital
RECRUITINGBoston, Massachusetts, 02114, United States
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Mayo Clinic Arizona
RECRUITINGPhoenix, Arizona, 85054, United States
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Mayo Clinic Florida
RECRUITINGJacksonville, Florida, 32224, United States
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Medical College of Wisconsin
NOT_YET_RECRUITINGMilwaukee, Wisconsin, 53226, United States
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Midatlantic Epilepsy and Sleep Center
RECRUITINGBethesda, Maryland, 20817, United States
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Northeast Regional Epilepsy Group
RECRUITINGHackensack, New Jersey, 07601, United States
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Ohio State University
RECRUITINGColumbus, Ohio, 43210, United States
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Robert Wood Johnson Hospital
RECRUITINGNew Brunswick, New Jersey, 08901, United States
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Stanford University
RECRUITINGPalo Alto, California, 94304, United States
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University of Alabama at Birmingham
RECRUITINGBirmingham, Alabama, 35294-0021, United States
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Conditions
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