New hope for managing dizzy spells in rare neurological disease

NCT ID NCT05696717

Summary

This study is testing whether a drug called ampreloxetine can safely and effectively reduce symptoms of low blood pressure when standing in people with multiple system atrophy (MSA). About 102 participants will take the drug for 20 weeks, then some will be randomly switched to a placebo to see if symptoms return. The main goal is to see if the drug helps people feel less dizzy and improves their ability to do daily activities.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • AOU San Giovanni di Dio e Ruggi d'Aragona, Salerno

    Salerno, 84131, Italy

  • Aqualane Clinical Research

    Naples, Florida, 34105, United States

  • Astra Clinic (Clinic4U)

    Tallinn, 11315, Estonia

  • Auckland City Hospital

    Grafton, Auckland, 1023, New Zealand

  • Autonomic Unit, National Hospital for Neurology & Neurosurgery

    London, WC1N 3BG, United Kingdom

  • Azienda Ospedaliera Santa Maria di Terni

    Terni, I-05100, Italy

  • Azienda Ospedaliera Universitaria Policlinico Tor Vergata

    Rome, 00133, Italy

  • Barts Health

    London, EC1M 6BQ, United Kingdom

  • Baylor College of Medicine

    Houston, Texas, 77030, United States

  • Bispebjerg Hospital

    Copenhagen, 2400-NV, Denmark

  • Brigham and Women's Hospital (Neuromuscular Division)

    Boston, Massachusetts, 02115, United States

  • CNS-Campus Neurologico Senior

    Torres Vedras, 2560-280, Portugal

  • Centre Hospitalier Universitaire de Bordeaux Health

    Bordeaux, 33076, France

  • Centre d'Investigation Clinique Hôpital Pierre Paul Rique

    Toulouse, 31059 Cedex, France

  • Centro de Pesquisa Clínica (CPC) do Hospital das Clínicas de Porto Alegre (HCPA)

    Porto Alegre, 90035-903, Brazil

  • Charite Universitaetsmedizin Berlin

    Berlin, 12203, Germany

  • Charité - Universitätsmedizin Berlin- Campus Mitte

    Berlin, 10117, Germany

  • David Geffen School of Medicine at UCLA

    Los Angeles, California, 90095, United States

  • Emory University

    Atlanta, Georgia, 30329, United States

  • Fondazione Policlinico Universitario Agostino Gemelli IRCCS

    Rome, 00168, Italy

  • Fundació Assistencial Mutua de Terrassa

    Terrassa, Barcelona, 08222, Spain

  • Fundación Scherbovsky

    Mendoza, M5500, Argentina

  • Hawaii Pacific Neuroscience

    Honolulu, Hawaii, 96817, United States

  • Hopital Caremeau

    Nîmes, Occitanie, Cedex 9, France

  • Hospital Británico de Buenos Aires

    CABA, C1280AEB, Argentina

  • Hospital General de Agudos Jose Maria Ramos Mejía

    CABA, C1221ADC, Argentina

  • Hospital Germans Trias i Pujol, Department of Neurology

    Barakaldo, Bizkaia, 48903, Spain

  • Hospital São Lucas - PUCRS

    Porto Alegre, 90610-000, Brazil

  • Hospital Universitario Infante Sofia Paseo Europa

    Madrid, 28702, Spain

  • Hospital Universitario de La Princesa

    Madrid, 28006, Spain

  • Hospital de Clínicas - Universidade Federal de Minas Gerais (HC - UFMG)

    Belo Horizonte, 30130-100, Brazil

  • INEBA Instituto Neurociencias Buenos Aires

    CABA, Buenos Aires F.D., C1192AAW, Argentina

  • IRCCS Istituto de Scienze Neurologiche di Bologna (ISNB)

    Bologna, 40139, Italy

  • Instituto Fleni

    CABA, Buenos Aires F.D., C1428AQK, Argentina

  • Instituto Investigación Sanitaria Biocruces

    Barakaldo, Bizkaia, 48903, Spain

  • Instituto de Neurologia de Curitiba S\C LTDA

    Curitiba, Paraná, 81210-310, Brazil

  • Instytut Zdrowia dr Boczarska-Jedynak Sp. z o.o., Sp.k.

    Oświęcim, 32-600, Poland

  • Krakowska Akademia Neurologii Sp.zo.o.

    Krakow, 31-505, Poland

  • Massachusetts Chan Medical School

    Worcester, Massachusetts, 01655, United States

  • Medical University of Innsbruck

    Innsbruck, A-6020, Austria

  • Medstar Georgetown University Hospital

    Washington D.C., District of Columbia, 20007, United States

  • Monash Health

    Clayton, Victoria, 3168, Australia

  • Movement Disorders Center of Arizona

    Scottsdale, Arizona, 85258, United States

  • Movement Disorders and Autonomic Disorders Clinic; University of Utah

    Salt Lake City, Utah, 84108, United States

  • Médico/Hospital de la Policía Federal Churruca Visca

    CABA, Buenos Aires F.D., C1437JCP, Argentina

  • NYU Langone Health NYU Dysautonomia Center

    New York, New York, 10016, United States

  • National Taiwan University Cancer Center

    Taipei, Taiwan, 106, Taiwan

  • Neuro-Care Sp. z o.o. Sp. Komandytowa

    Katowice, 40-749, Poland

  • Neurocentrum-Miwomed

    Gdansk, 80-207, Poland

  • Neurostudies, Inc

    Port Charlotte, Florida, 33952, United States

  • Northshore University Health System

    Glenview, Illinois, 60026-1339, United States

  • Parkinson's Centre of Ospedale CTO

    Milan, 20126, Italy

  • Parkinson's Disease And Movement Disorders Center of Boca Raton

    Boca Raton, Florida, 33486, United States

  • Pia Fond. Cardinale Giovanni Panico Azienda Ospedaliera

    Tricase, 73039, Italy

  • Praxis Dr. Oehlwein, Outpatient Clinic

    Gera, Thuringia, 07551, Germany

  • Quest Research Institute

    Farmington Hills, Michigan, 48334, United States

  • Rush University Medical Center

    Chicago, Illinois, 60612, United States

  • SFM Clinical Research, LLC

    Boca Raton, Florida, 33487, United States

  • Salford Royal Hospital

    Salford, M6 8HD, United Kingdom

  • Santa Chiara Hospital

    Trento, 38122, Italy

  • Semmelweis Egyetem

    Budapest, 1085, Hungary

  • Stanford Neuroscience Health Center

    Palo Alto, California, 94304, United States

  • Tartu University Hospital

    Tartu, 30029, Estonia

  • The Alfred Hospital

    Melbourne, Victoria, 3168, Australia

  • The Neurological Institute at Columbia University Medical Center

    New York, New York, 10032, United States

  • The Parkinson's and Movement Disorder Institute

    Fountain Valley, California, 92708, United States

  • Theravance Biopharma Investigative Site

    Parkville, Victoria, 3050, Australia

  • Theravance Biopharma Investigative Site

    Tel Aviv, 64239, Israel

  • Theravance Biopharma Investigative Site

    Christchurch, 8011, New Zealand

  • UC San Diego Movement Disorder Center

    La Jolla, California, 92037, United States

  • Universitatsklinikum Tulln

    Tulln, Austria

  • University Hospitals Birmingham NHS Foundation Trust

    Birmingham, B15 2GW, United Kingdom

  • University of Belgrade Neurology Clinic

    Belgrade, 11000, Serbia

  • University of Calgary - Health Sciences Centre

    Calgary, Alberta, T2N 4Z6, Canada

  • University of Cincinnati Medical Center

    Cincinnati, Ohio, 45219, United States

  • University of Kansas Medical Center Research Institute, Inc.

    Kansas City, Kansas, 66160, United States

  • University of South Florida Ataxia Research Center

    Tampa, Florida, 33612, United States

  • University of Texas Southwestern Medical Center

    Dallas, Texas, 75390, United States

  • Vanderbilt University Medical Center

    Nashville, Tennessee, 37232, United States

Conditions

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