Drug combo tested for Tough-to-Treat blood cancer in frail patients
NCT ID NCT04150029
Summary
This study tested the safety and effectiveness of an experimental drug called MBG453 when combined with two existing drugs (azacitidine and venetoclax) for adults newly diagnosed with acute myeloid leukemia (AML) who were too frail for standard intensive chemotherapy. It aimed to see if this three-drug combination could help control the cancer. The trial was terminated early by the sponsor, so full results are limited.
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Contacts and locations
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Locations
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25Uni of Alabama at Birmingham
Birmingham, Alabama, 35294, United States
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Chattanooga Onc And Hem Assoc PC
Chattanooga, Tennessee, 37404, United States
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Dana Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Duke Univ Medical Center
Durham, North Carolina, 27710, United States
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Huntsman Cancer Institute Univ of Utah
Salt Lake City, Utah, 84112 0550, United States
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Levine Cancer Insitute Carolinas Healthcare System
Charlotte, North Carolina, 28204, United States
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MD Anderson Cancer Center University of Texas
Houston, Texas, 77030, United States
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Mayo Clinic Rochester
Rochester, Minnesota, 55905, United States
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Memorial Sloan Kettering
New York, New York, 10017, United States
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Novartis Investigative Site
Clayton, Victoria, 3168, Australia
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Novartis Investigative Site
Vancouver, British Columbia, V5Z 1M9, Canada
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Novartis Investigative Site
Toronto, Ontario, M5G 2M9, Canada
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Novartis Investigative Site
Montreal, Quebec, H3T 1E2, Canada
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Novartis Investigative Site
Paris, 75475, France
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Novartis Investigative Site
Toulouse, 31059, France
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Novartis Investigative Site
Leipzig, Saxony, 04103, Germany
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Novartis Investigative Site
Berlin, 13353, Germany
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Novartis Investigative Site
Milan, MI, 20162, Italy
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Novartis Investigative Site
Roma, RM, 00133, Italy
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Novartis Investigative Site
Fukushima, Fukushima, 960 1295, Japan
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Novartis Investigative Site
Yamagata, Yamagata, 990 9585, Japan
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Novartis Investigative Site
Seoul, Seocho gu, 06591, South Korea
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Novartis Investigative Site
Barcelona, 08036, Spain
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Novartis Investigative Site
Madrid, 28009, Spain
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Novartis Investigative Site
Kaohsiung City, 83301, Taiwan
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Uni Of Iowa Hospitals And Clinics
Iowa City, Iowa, 52242, United States
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Weill Cornell Medicine NY-Presb
New York, New York, 10021, United States
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Yale University School Of Medicine
New Haven, Connecticut, 06520, United States
Conditions
Explore the condition pages connected to this study.