New hope for kids with tough-to-beat leukemia

NCT ID NCT03263936

Completed Disease control Sponsor: Therapeutic Advances in Childhood Leukemia Consortium Source: ClinicalTrials.gov ↗

Summary

This study tested whether adding two drugs (decitabine and vorinostat) before standard chemotherapy could help children and young adults whose acute myeloid leukemia (AML) has come back or hasn't responded to treatment. The main goal was to find the safest dose of this new combination. It involved 37 participants aged 1 to 25 years.

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Contacts and locations

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Locations

All Children's Hospital

St. Petersburg, Florida, 33701, United States
British Columbia Children's Hospital

Vancouver, British Columbia, V6H 3V4, Canada
C.S. Mott Children's Hospital

Ann Arbor, Michigan, 48109-0914, United States
CS Mott Children's Hospital, Ann Arbor

Ann Arbor, Michigan, 48109, United States
Children's Healthcare of Atlanta, Emory University

Atlanta, Georgia, 30322, United States
Children's Hospital Los Angeles

Los Angeles, California, 90027, United States
Children's Hospital New York-Presbyterian

New York, New York, 10032, United States
Children's Hospital Orange County

Orange, California, 92868, United States
Children's Hospital at Westmead

Westmead, Australia
Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, 19104, United States
Children's Hospitals and Clinics of Minnesota

Minneapolis, Minnesota, 55404, United States
Children's National Medical Center

Washington D.C., District of Columbia, 20010, United States
Cincinnati Children's Hospital

Cincinnati, Ohio, 45229, United States
Cook Children's Medical Center

Fort Worth, Texas, 76104, United States
Dana-Farber Cancer Institute

Boston, Massachusetts, 02215, United States
Hospital for Sick Children

Toronto, Ontario, M5G 1X8, Canada
Johns Hopkins University

Baltimore, Maryland, 21231, United States
Levine Children's Hospital

Charlotte, North Carolina, 28203, United States
Lurie Children's Hospital of Chicago

Chicago, Illinois, 60611, United States
Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
National Cancer Institute, Pediatric Oncology Branch

Bethesda, Maryland, 20892, United States
Nationwide Children's Hospital

Columbus, Ohio, 43205, United States
New York University Medical Center

New York, New York, 10016, United States
Oregon Health and Science University

Portland, Oregon, 97239, United States
Primary Children's Hospital

Salt Lake City, Utah, 84113, United States
Sainte Justine University Hospital

Montreal, Quebec, Canada
Seattle Children's Hospital

Seattle, Washington, 98105, United States
Sidney Kimmel Cancer Center at Johns Hopkins

Baltimore, Maryland, 21231, United States
Sydney Children's Hospital

Randwick, New South Wales, 2031, Australia
Texas Children's Cancer Center, Baylor

Houston, Texas, 77030, United States
The Children's Hospital, University of Colorado

Aurora, Colorado, 80045, United States
UCSF School of Medicine

San Francisco, California, 94158, United States
University of Miami

Miami, Florida, 33136, United States

Conditions

Explore the condition pages connected to this study.

ACUTE MYELOGENOUS LEUKEMIA