New drug combo shows promise in lung cancer battle
NCT ID NCT04487080
First seen Oct 31, 2025 · Last updated Apr 23, 2026 · Updated 25 times
Summary
This study tests whether a combination of two drugs, amivantamab and lazertinib, works better than the current standard drug osimertinib for people with advanced non-small cell lung cancer that has a specific EGFR gene mutation. About 1,074 participants with newly diagnosed, untreated cancer will be randomly assigned to one of three treatment groups. The main goal is to see how long the cancer stays under control before it starts growing again.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Adana City Hospital
Adana, 01060, Turkey (Türkiye)
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Algemeen Ziekenhuis Delta
Roeselare, 8800, Belgium
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Ankara Bilkent City Hospital
Ankara, 6800, Turkey (Türkiye)
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Aou San Luigi Gonzaga
Orbassano, 10043, Italy
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Arizona Oncology Associates, PC - HAL
Goodyear, Arizona, 85395, United States
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Asan Medical Center
Seoul, 05505, South Korea
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Asklepios Klinik Gauting GmbH - Asklepios Fachkliniken Munchen-Gauting
Gauting, 82131, Germany
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Astera Cancer Care
East Brunswick, New Jersey, 08816, United States
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Austin Hospital
Heidelberg, 3084, Australia
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Azienda Ospedaliero Univ. Policlinico Gaspare Rodolico
Catania, 95123, Italy
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Basavatarakam Indo-American Hospital
Hyderabad, 500034, India
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Bashkir State Medical University
Ufa, 450083, Russia
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Başkent University Medical Faculty Adana Application and Research Center
Adana, 01250, Turkey (Türkiye)
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Beacon Hospital Sdn Bhd
Petaling Jaya, 46050, Malaysia
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Beijing Cancer Hospital Respiratory Medicine Department I
Beijing, 100142, China
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Beijing Cancer Hospital Respiratory Medicine Department II
Beijing, 100142, China
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Beijing Chest hospital, Capital medical university
Beijing, 101149, China
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Beijing Friendship Hospital Capital Medical University
Beijing, 100050, China
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CHU Bordeaux
Pessac, 33604, France
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CHU Bretonneau
Tours, 37000, France
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CHU Nantes
Sain-Herblain, 44800, France
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CHU de Grenoble Hopital Albert Michallon
La Tronche, 38700, France
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CHU de Limoges
Limoges, 87000, France
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CIMOVA, Morals Vargas Centro de Investigación SC
León, 37000, Mexico
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Cabrini Medical Centre
Malvern, 3144, Australia
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Cancer Hospital of Xinjiang Medical University
Ürümqi, 830000, China
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Cancer Specialists of North Florida
Jacksonville, Florida, 32256, United States
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Centro Oncologico Riojano Integral (Cori)
La Rioja, F5300COE, Argentina
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Centro Oncológico Korben
Buenos Aires, C1426AGE, Argentina
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Centrum Onkologii im Prof F Lukaszczyka
Bydgoszcz, 85 796, Poland
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Cetus Oncologia
Belo Horizonte, 30110-022, Brazil
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Chaim Sheba Medical Center
Ramat Gan, 5262100, Israel
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Chang Gung Medical Foundation
Kaohsiung City, 833, Taiwan
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Chelsea And Westminster Hospital
London, SW10 9NH, United Kingdom
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Chiang Mai University
Chiang Mai, 50200, Thailand
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China Medical University Hospital
Taichung, 40447, Taiwan
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Chinese PLA General Hospital
Beijing, 100853, China
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Christie NHS Foundation Trust
Manchester, M20 4BX, United Kingdom
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Chung Shan Medical University Hospital
Taichung, 402, Taiwan
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Chungbuk National University Hospital
Cheongju-si, 28644, South Korea
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City Clinical Hospital #1
Nal'chik, 360000, Russia
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City of Hope Long Beach Elm
Long Beach, California, 90813, United States
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Clinica Univ. de Navarra
Pamplona, 31008, Spain
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Clinique Saint Pierre
Ottignies, 1340, Belgium
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Cliniques Universitaires Saint Luc
Brussels, 1200, Belgium
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Clínica Viedma
Viedma, R8500ACE, Argentina
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Current medical technologies
Saint Petersburg, 190121, Russia
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Dnipropetrovsk State Medical Academy, Dnipropetrovsk City Multifield Clinical Hospital # 4
Dnipro, 49102, Ukraine
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E-DA Hospital
Kaohsiung City, 824, Taiwan
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East Jefferson General Hospital
Metairie, Louisiana, 70006, United States
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Edinburgh Cancer Centre Western General
Edinburgh, EH4 2XU, United Kingdom
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Ehime University Hospital
Toon-shi, 791-0295, Japan
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Fejer Varmegyei Szent Gyorgy Egyetemi Oktatokorhaz
Székesfehérvár, 8000, Hungary
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Flinders Medical Centre
Bedford Park, 5042, Australia
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Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico
Milan, 20122, Italy
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Fondazione IRCCS Istituto Nazionale dei Tumori
Milan, 20133, Italy
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Fudan University Shanghai Cancer Center
Shanghai, 200032, China
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Fundacao Antonio Prudente A C Camargo Cancer Center
São Paulo, 01509 900, Brazil
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Fundacao Faculdade de Medicina Instituto do Cancer do Estado de Sao Paulo
São Paulo, 01246 000, Brazil
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Fundacao Pio XII
Barretos, 14784-400, Brazil
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Gazi Hastanesi
Ankara, 06560, Turkey (Türkiye)
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Grand Hopital De Charleroi Site Les Viviers
Charleroi, 6060, Belgium
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HCG Manavta Cancer Centre
Nashik, 422002, India
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HIA Begin
Saint-Mandé, 94163, France
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Hadassah Medical Center
Jerusalem, 9112001, Israel
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Harbin medical university cancer hospital
Harbin, 150000, China
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Health Pharma Professional Research
México, 03100, Mexico
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Helios Klinikum Emil von Behring GmbH
Berlin, 14165, Germany
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Henan Cancer Hospital
Zhengzhou, 450008, China
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Henry Ford Hospital
Detroit, Michigan, 48202, United States
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Hopital Nord
Marseille, 13915, France
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Hopital Tenon
Paris, 75970, France
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Hosp Regional Univ de Malaga
Málaga, 29011, Spain
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Hosp Univ A Coruna
A Coruña, 15006, Spain
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Hosp Univ Vall D Hebron
Barcelona, 08035, Spain
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Hosp. Clinico Univ. Lozano Blesa
Zaragoza, 50009, Spain
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Hosp. Cuf Porto
Porto, 4100 180, Portugal
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Hosp. Gral. Univ. Gregorio Maranon
Madrid, 28007, Spain
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Hosp. Gral. Univ. Valencia
Valencia, 46014, Spain
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Hosp. Univ. 12 de Octubre
Madrid, 28041, Spain
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Hosp. Univ. La Paz
Madrid, 28046, Spain
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Hosp. Univ. Pta. de Hierro Majadahonda
Majadahonda, 28222, Spain
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Hosp. Univ. Quiron Dexeus
Barcelona, 08028, Spain
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Hosp. Univ. de Burgos
Burgos, 09003, Spain
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Hosp. Virgen Del Rocio
Seville, 41013, Spain
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Hosp. de La Santa Creu I Sant Pau
Barcelona, 08025, Spain
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Hospices Civils de Lyon HCL
Bron, 69500, France
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Hospital Civil de Guadalajara Fray Antonio Alcalde
Guadalajara, 44280, Mexico
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Hospital Evangélico de Cachoeiro de Itapemirim
Vitória, 29308-014, Brazil
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Hospital Kuala Lumpur
Kuala Lumpur, 50586, Malaysia
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Hospital Privado Centro Medico de Cordoba
Córdoba, X5016KEH, Argentina
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Hospital Pulau Pinang
George Town, 10990, Malaysia
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Hospital Sultan Ismail
Johor Bahru, 81100, Malaysia
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Hospital Tengku Ampuan Afzan
Kuantan, 25100, Malaysia
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Huizhou Municipal Central Hospital
Huizhou, 516001, China
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Hunan Cancer hospital Thoracic Medicine Department I
Changsha, 410013, China
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Hunan Cancer hospital Thoracic Medicine Department II
Changsha, 410013, China
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IOS - Instituto de Oncologia de Sorocaba Dr. Gilson Delgado
Sorocaba, 18030-075, Brazil
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IRCCS Ospedale San Raffaele
Milan, 20132, Italy
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Inje University Haeundae Paik Hospital
Busan, 48108, South Korea
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Inst. Cat. D'Oncologia-Badalona
Badalona, 08916, Spain
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Institut Bergonie
Bordeaux, 33000, France
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Institut Català D'Oncologia Girona
Girona, 17007, Spain
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Institut Curie
Paris, 75005, France
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Institut Gustave Roussy
Villejuif, 94805, France
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Institute Coeur Poumon
Lille, 59000, France
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Instituto Alexander Fleming
Buenos Aires, C1428ANZ, Argentina
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Instituto D Or de Pesquisa e Ensino IDOR
Rio de Janeiro, 22281 100, Brazil
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Instituto Nacional de Cancerologia
México, 14080, Mexico
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Instituto Portugues de Oncologia
Porto, 4200-072, Portugal
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Irccs Gemelli
Roma, 00168, Italy
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Irkutsk Regional Oncology Dispensary
Irkutsk, 664035, Russia
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Irmandade Santa Casa de Misericordia de Porto Alegre
Porto Alegre, 90020-090, Brazil
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Istanbul Universitesi Cerrahpasa Tip Fakultesi Ic Hastaliklari Anabilim Dali Medikal Onkoloji Bd
Istanbul, 34098, Turkey (Türkiye)
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Istituto Clinico Humanitas
Rozzano, 20089, Italy
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Istituto Europeo di Oncologia
Milan, 20141, Italy
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Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori
Meldola, 47014, Italy
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Jeroen Bosch Ziekenhuis
's-Hertogenbosch, 5223 GZ, Netherlands
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Jilin cancer hospital
Changchun, 130000, China
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Juntendo University Hospital
Bunkyō City, 113 8431, Japan
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Juravinski Cancer Centre
Hamilton, Ontario, L8V 5C2, Canada
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Kanazawa University Hospital
Kanazawa, 920 8641, Japan
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Kangbuk Samsung Hospital
Seoul, 03181, South Korea
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Kansai Medical University Hospital
Hirakata, 573 1191, Japan
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Kaohsiung Medical University Chung Ho Memorial Hospital
Kaohsiung City, 807, Taiwan
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Kindai University Hospital
Osaka Sayama Shi, 589 8511, Japan
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Kliniken der Stadt Koeln gGmbH
Cologne, 51109, Germany
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Korea University Guro Hospital
Seoul, 8308, South Korea
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Krasnoyarsk Regional Oncology Dispensary
Krasnoyarsk, 660133, Russia
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Kurume University Hospital
Kurume, 830-0011, Japan
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Leningrad Regional Oncology Dispensary
Kuzmolovsky, 188663, Russia
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Liga Norte Riograndense Contra O Cancer
Natal, 59062 000, Brazil
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MCK
Moscow, 115533, Russia
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Markusovszky Egyetemi Oktatokorhaz
Szombathely, 9700, Hungary
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Maryland Oncology Hematology, PA
Columbia, Maryland, 21044, United States
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Matsusaka Municipal Hospital
Matsusaka, 515-8544, Japan
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Mayo Clinic
Rochester, Minnesota, 55905, United States
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McGill University Health Centre
Montreal, Quebec, H4A 3J1, Canada
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Medical Center 'Ok Clinic' of LLC 'International Institute of Clinical Studies'
Kyiv, 02091, Ukraine
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Medical Point
Izmir, 35575, Turkey (Türkiye)
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Medipol Mega University Hospital
Istanbul, 34214, Turkey (Türkiye)
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Meir Medical Center
Kfar Saba, 44281, Israel
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Mexico Centre for Clinical Research, S.A. de C.V.
Mexico City, 03100, Mexico
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Ministerio da Saude Instituto Nacional do Cancer
Rio de Janeiro, 20231 050, Brazil
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Minnesota Oncology Hematology P A
Edina, Minnesota, 55435, United States
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Moscow City Oncology Hospital № 62
Krasnogorsk, 143423, Russia
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Municipal Oncology Centre of Uzhgorod Central Municipal Clinical Hospitlal
Uzhhorod, 88000, Ukraine
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Municipal non-profit enterprise 'Regional Center of Oncology'
Kharkiv, 61070, Ukraine
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Mátrai Gyógyintézet-Bronchológia
Gyöngyös, 3233, Hungary
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Médica Sur
Mexico City, 14050, Mexico
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N.N. Petrov Research Institute Of Oncology
Saint Petersburg, 197758, Russia
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Nantong Tumor Hospital
Nantong, 226300, China
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Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut Badawczy
Warsaw, 02-781, Poland
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National Cancer Center Hospital
Chūōku, 104 0045, Japan
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National Cancer Center Hospital East
Kashiwa, 277 8577, Japan
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National Cheng Kung University Hospital
Tainan, 704, Taiwan
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National Hospital Organization Himeji Medical Center
Himeji, 670-8520, Japan
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National Hospital Organization Iwakuni Clinical Center
Yamaguchi, 740-8510, Japan
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National Hospital Organization Kyushu Medical Center
Fukuoka, 810-8563, Japan
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National Hospital Organization Osaka Toneyama Medical Center
Toyonaka-shi, 560-8552, Japan
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National Hospital Organization Shibukawa Medical Center
Shibukawa, 377-0280, Japan
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National Hospital Organization Tokyo Medical Center
Tokyo, 152 8902, Japan
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National Hospital Organization Yamaguchi Ube Medical Center
Yamaguchi, 755-0241, Japan
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National Taiwan University Hospital
Taipei, 10002, Taiwan
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Necmettin Erbakan University Meram Medical Faculty
Konya, 42080, Turkey (Türkiye)
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Niigata Cancer Center Hospital
Niigata, 951-8566, Japan
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Nizhny Novgorod Regional Oncological Dispensary
Nizhny Novgorod, 603000, Russia
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Noble Hospital Pvt Ltd
Pune, 411013, India
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Nottingham University Hospitals NHS Trust
Nottingham, NG5 1PB, United Kingdom
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Núcleo de Pesquisa São Camilo
São Paulo, 04014-002, Brazil
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Okayama University Hospital
Okayama, 700 8558, Japan
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Omsk Clinical Oncology Dispensary
Omsk, 664013, Russia
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Oncoclinicas Rio de Janeiro S A
Rio de Janeiro, 22 250 905, Brazil
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Oncologia Integral Satelite
Naucalpan, 53100, Mexico
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Oncology Consultants Texas
Houston, Texas, 77030, United States
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Oncology Medical Clinics AV Medical group
Saint Petersburg, 196006, Russia
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Oncosite - Centro de Pesquisa Clínica em Oncologia Ltda
Ijuí, 98700-000, Brazil
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Onkologische Schwerpunktpraxis
Heilbronn, 74072, Germany
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Orszagos Koranyi Tbc es Pulmonologiai Intezet
Budapest, H-1529, Hungary
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Ospedale Monaldi
Naples, 80100, Italy
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Ospedale S. Maria Delle Croci
Ravenna, 48121, Italy
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Ospedale San Giuseppe Moscati di Avellino
Avellino, 83100, Italy
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POIS Leipzig GbR
Leipzig, 04357, Germany
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Pan American Center for Oncology Trials LLC
Rio Piedras, 00935, Puerto Rico
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Phramongkutklao Hospital and Medical College
Bangkok, 10400, Thailand
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Pius-Hospital Oldenburg
Oldenburg, 26121, Germany
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Princess Alexandra Hospital
Woolloongabba, 4102, Australia
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Private Specialist Hospitals - MedPolonia
Poznan, 60-693, Poland
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Rabin Medical Center
Petah Tikva, 49100, Israel
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Rambam Health Corporation
Haifa, 3109601, Israel
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Rijnstate Ziekenhuis
Arnhem, 6815 AD, Netherlands
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Robert-Bosch-Krankenhaus - Klinik Schillerhoehe
Stuttgart, 70376, Germany
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Rocky Mountain Cancer Centers
Lone Tree, Colorado, 80124, United States
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Ruijin Hospital Shanghai Jiao Tong University
Shanghai, 200025, China
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Samsung Medical Center
Seoul, 06351, South Korea
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San Gerardo Hospital
Monza, 20052, Italy
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Sarah Cannon Research Institute
Nashville, Tennessee, 37203, United States
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Second Affiliated Hospital, School of Medicine, Zhejiang University
Hangzhou, 310009, China
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Seoul National University Bundang Hospital
Seongnam-si, 13620, South Korea
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Severance Hospital Yonsei University Health System
Seoul, 03722, South Korea
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Shanghai Chest Hospital
Shanghai, 200030, China
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Shanghai East Hospital
Shanghai, 200123, China
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Shengjing Hospital Of China Medical University
Shenyang, 110022, China
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Sichuan Cancer Hospital
Chengdu, 610041, China
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Sir Charles Gairdner Hospital
Nedlands, 6009, Australia
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Sir Run Run Shaw Hospital Zhejiang University School of Medicine
Hangzhou, 310016, China
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Siriraj Hospital
Bangkok, 10700, Thailand
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Songklanagarind Hospital, Prince of Songkla University
Songkhla, 90110, Thailand
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Southern Medical Day Care Centre
Wollongong, 2500, Australia
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Southwest Hospital
Chongqing, 400038, China
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St John of God Hospital Murdoch
Murdoch, 6150, Australia
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State Nonprofit Enterprise National Cancer Institute
Kyiv, 03022, Ukraine
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Städtisches Krankenhaus Martha-Maria Halle-Dölau gGmbH
Halle, 06120, Germany
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Sun Yat-Sen Memorial Hospital Sun Yat-sen University
Guangzhou, 510120, China
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Szpitale Pomorskie Sp z o o
Gdynia, 81 519, Poland
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T C Saglik Bakanlıgi Goztepe Prof Dr Suleyman Yalcın Sehir Hastanesi
Istanbul, 34722, Turkey (Türkiye)
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Taipei Medical University Shuang Ho Hospital
New Taipei City, 23561, Taiwan
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Taizhou Hospital of Zhejiang Province
Linhai, 317000, China
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Tambov Regional Oncology Clinical Dispansary
Tambov, 392013, Russia
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Tata Medical Center
Kolkata, 700160, India
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Tata Memorial Hospital
Mumbai, 400012, India
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Tel Aviv Sourasky Medical Center
Tel Aviv, 6423906, Israel
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Texas Oncology P A
Austin, Texas, 78745, United States
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The Cancer Institute Hospital of JFCR
Tokyo, 135 8550, Japan
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The Catholic University of Korea Seoul St Mary s Hospital
Seoul, 06591, South Korea
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The First Affiliated Hospital Sun Yat sen University
Guangzhou, 510080, China
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The First Affiliated Hospital of Wenzhou Medical University
Wenzhou, 325000, China
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The First Affiliated Hospital of Xian Jiaotong University
Xi'an, 710061, China
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The First People's Hospital Of Changzhou
Changzhou, 213003, China
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The Ottawa Hospital Cancer Centre
Ottawa, Ontario, K1H 8L6, Canada
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The Royal Marsden NHS Trust
London, SW3 6JJ, United Kingdom
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The Royal Marsden NHS Trust 1
Sutton, SM2 5PT, United Kingdom
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The Second Affiliated Hospital of Zhejiang University College of Medicine
Hangzhou, 310009, China
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Thoraxklinik am Universitatsklinikum Heidelberg
Heidelberg, 69126, Germany
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Tianjin Medical University General Hospital
Tianjin, 300052, China
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Tomsk Cancer Research Institute
Tomsk, 634050, Russia
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TongJi Hospital of TongJi Medical College of Huazhong University of Science & Technology
Wuhan, 430030, China
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Trakya University Medical Faculty
Edirne, 22030, Turkey (Türkiye)
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Tudogyogyintezet Torokbalint
Törökbálint, 2045, Hungary
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UCL Cancer Institute
London, NW1 2PG, United Kingdom
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UMC Radboud
Nijmegen, 6525AG, Netherlands
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UPCO Unidade de Pesquisa Clinica em Oncologia
Pelotas, 96020 080, Brazil
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UZ Leuven
Leuven, 3000, Belgium
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Uls Santa Maria - Hosp. Pulido Valente
Lisbon, 1769-001, Portugal
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Uls Santo Antonio - Hosp. Santo Antonio
Porto, 4099-001, Portugal
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Uniao Brasileira de Educacao e Assistencia Hospital Sao Lucas da PUCRS
Porto Alegre, 90610-000, Brazil
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Universitaetsklinikum Essen
Essen, 45147, Germany
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University Cancer And Blood Center LLC
Athens, Georgia, 30607, United States
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University Malaya Medical Centre
Kuala Lumpur, 59100, Malaysia
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University of California Irvine
Orange, California, 92868, United States
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University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, 15232, United States
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Uniwersyteckie Centrum Kliniczne
Gdansk, 80 214, Poland
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Veszprém Megyei Tudőgyógyintézet
Farkasgyepü, 8582, Hungary
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Virginia Cancer Specialists
Fairfax, Virginia, 22031, United States
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Wakayama Medical University Hospital
Wakayama, 641 8510, Japan
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Warminsko-Mazurskie Centrum Chorob Pluc w Olsztynie
Olsztyn, 10-357, Poland
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Washington University School Of Medicine
St Louis, Missouri, 63110, United States
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West China Hospital Sichuan University
Chengdu, 610041, China
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Westmead Hospital
Westmead, 2145, Australia
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Willamette Valley Cancer Institute and Research Center
Eugene, Oregon, 97401, United States
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William Osler Health System
Brampton, Ontario, L6R 3J7, Canada
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Yantai Yuhuangding Hospital
Yantai, 264000, China
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Yaroslavl Regional Clinical Oncology Hospital
Yaroslavl, 150054, Russia
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Ynova Pesquisa Clinica
Florianópolis, 88020-210, Brazil
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Yuma Regional Medical Center
Yuma, Arizona, 85364, United States
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Zentralklinik Bad Berka GmbH
Bad Berka, 99437, Germany
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Zhejiang Cancer Hospital
Hangzhou, 310022, China
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Ziekenhuis St Jansdal
Harderwijk, 3844 DG, Netherlands
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i Can Oncology Center
Monterrey, 64710, Mexico
Conditions
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