Race to stop Alzheimer's before it starts: major drug trial targets silent brain changes

NCT ID NCT04468659

Ongoing Prevention Sponsor: Eisai Inc. Source: ClinicalTrials.gov ↗

Summary

This large study is testing whether the drug lecanemab can prevent or delay Alzheimer's disease in people who have early signs of the disease in their brains but do not yet have memory problems or other symptoms. It involves 1,400 participants aged 55-80 who have intermediate or elevated levels of a protein called amyloid in their brains. The main goal is to see if four years of treatment can slow cognitive decline or reduce amyloid buildup compared to a placebo.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

AMC Research

Matthews, North Carolina, 28105, United States
Abington Neurological Associates

Abington, Pennsylvania, 19001, United States
Advanced Clinical Research Network, Corp

Coral Gables, Florida, 33134-1613, United States
Advanced Memory Research Institute of New Jersey

Toms River, New Jersey, 08755, United States
Alzheimer's Research Australia

Nedlands, Western Australia, 6009, Australia
Alzheimer's Research and Treatment Center

Wellington, Florida, 33414, United States
Austin Hospital - Medical and Cognitive Research Unit

Ivanhoe, Victoria, Australia
Banner Alzheimer's Institute

Phoenix, Arizona, 85006, United States
Banner Sun Health Research Institute

Sun City, Arizona, 85351, United States
Barcelona Beta Brain Research Center

Barcelona, 08005, Spain
Baylor College of Medicine

Houston, Texas, 77030, United States
Boston University

Boston, Massachusetts, 02118, United States
Brain Matters Research

Delray Beach, Florida, 33445, United States
Brigham and Woman's Hospital Center for Alzheimer Research and Treatment

Boston, Massachusetts, 21155, United States
Bristol Brain Centre

Bristol, BS10 5NB, United Kingdom
Butler Hospital Memory and Aging Program

Providence, Rhode Island, 02906, United States
CALHN Memory Trials

Adelaide, South Australia, Australia
Calvary Mater Newcastle

Waratah, New South Wales, Australia
Case Western Reserve University/University Hospitals

Beachwood, Ohio, 44122, United States
Central States Research, LLC

Tulsa, Oklahoma, 74136, United States
Centricity Research

Hailfax, Nova Scotia, B3S 1L8, Canada
Charter Research

Winter Park, Florida, 31792, United States
Cleveland Clinic Lou Ruvo Center for Brain Health

Las Vegas, Nevada, 89106, United States
Cleveland Clinic Lou Ruvo Center for Brain Health

Cleveland, Ohio, 44195, United States
Columbia University

New York, New York, 10032, United States
Columbus Memory Center, PC

Columbus, Georgia, 31909, United States
Donald S.Marks, M.D.,P.C.

Plymouth, Massachusetts, 02360, United States
Duke Health Center

Durham, North Carolina, 27705, United States
Eastern Virginia Medical School

Norfolk, Virginia, 23507, United States
Emory University

Atlanta, Georgia, 30329, United States
Fukuoka University Hospital

Fukuoka, Fukuoka, Japan
Fundacion CITA ALZHEIMER

Donostia / San Sebastian, 20009, Spain
Fundació ACE

Barcelona, 08028, Spain
Georgetown University

Washington D.C., District of Columbia, 20057, United States
Glasgow Memory Clinic

Glasgow, ML1 4UF, United Kingdom
Gonzalez MD & Aswad MD Health Sciences

Miami, Florida, 33125, United States
Hoag Memorial Hospital Presbyterian

Newport Beach, California, 92663, United States
Hospital Universitario Marqués de Valdeciila

Santander, 39008, Spain
Hospital Universitario Quirón Salud Madrid

Madrid, 28223, Spain
Houston Methodist Neurological Institute

Houston, Texas, 77030, United States
Howard University

Washington D.C., District of Columbia, 20060, United States
ICR Clinical Research Hospital Tokyo

Shinjuku-Ku, Tokyo, Japan
Icahn School of Medicine at Mount Sinai

New York, New York, 10029, United States
Imperial Memory Unit

London, W6 8RF, United Kingdom
Indiana University School of Medicine

Indianapolis, Indiana, 46202, United States
Johns Hopkins University

Baltimore, Maryland, 21224, United States
K2 Medical Research

Maitland, Florida, 32751, United States
K2 Medical Research - The Villages

Lady Lake, Florida, 32159, United States
K2 Medical Research, Llc

Maitland, Florida, 32751, United States
Keystone Clinical Studies, LLC

Norristown, Pennsylvania, 19403, United States
Kobe University Hospital

Kobe, Hyōgo, 650-0017, Japan
Koseikai Takeda Hospital

Kyoto, Kyoto, Japan
Mayo Clinic Jacksonville

Jacksonville, Florida, 32224, United States
Mayo Clinic, Rochester

Rochester, Minnesota, 55905, United States
Medical Corporation Heishinkai OPHAC Hospital

Osaka, Osaka, Japan
Medical Corporation Heishinkai OPHAC Hospital

Suita-shi, Osaka, Japan
National Center for Geriatrics and Gerontology

Obu-shi, Aichi-ken, Japan
National Center of Neurology and Psychiatry

Kodaira-shi, Tokyo, Japan
National Clinical Research, Inc

Richmond, Virginia, 23294, United States
National University Hospital

Singapore, Singapore
Northwestern University

Chicago, Illinois, 60611, United States
Ohio State University

Columbus, Ohio, 43210, United States
Oregon Health & Science University

Portland, Oregon, 97239, United States
P-One Clinic, Keikokai Medical Corporation

Hachioji -shi, Tokyo, Japan
Parkwood Institute Main Building

London, Ontario, N6C0A7, Canada
Ralph H. Johnson VA Medical Center

Charleston, South Carolina, 20403, United States
Ralph H. Johnson VA Medical Center

Charleston, South Carolina, 29403, United States
Renstar Medical Research

Ocala, Florida, 34470, United States
Rhode Island Hospital

Providence, Rhode Island, 02903, United States
Rush University Medical Center

Chicago, Illinois, 60612, United States
SIBCR

Seattle, Washington, 98108, United States
Sharp Mesa Vista Hospital

San Diego, California, 92123, United States
Shonan Kamakura General Hospital

Kamakura-shi, Kanagawa, Japan
St Pancras Clinical Research

London, EC2Y 8EA, United Kingdom
St Vincent's Hospital Sydney

Darlinghurst, New South Wales, Australia
Stanford University

Palo Alto, California, 94304, United States
Summit Research Network, Oregon

Portland, Oregon, 97210, United States
Sunnybrook Health Sciences Centre

Toronto, Ontario, M4N 3M5, Canada
Synexus Clinical Research

Orlando, Florida, 32806, United States
Synexus Clinical Research

The Villages, Florida, 32162, United States
The University of Texas Health Science Center at San Antonio

San Antonio, Texas, 78229-3900, United States
The University of Tokyo Hospital

Bunkyo-ku, Tokyo, Japan
Tohoku University Hospital

Sendai, Miyagi, Japan
Tokyo Metropolitan Geriatric Hospital

Itabashi-ku, Tokyo, Japan
Toronto Memory Program

Toronto, Ontario, M3B 2S7, Canada
True North Clinical Research

New Minas, Nova Scotia, B4N 3R7, Canada
True North Clinical Research Inc.

New Minas, Nova Scotia, B4N 3R7, Canada
UCI MIND

Irvine, California, 92697-4285, United States
Univeristy of California, San Francisco

San Francisco, California, 94158, United States
University of Alabama, Birmingham

Birmingham, Alabama, 35233, United States
University of California, Davis

Walnut Creek, California, 94598, United States
University of Kansas

Fairway, Kansas, 66205, United States
University of Kentucky

Lexington, Kentucky, 40504, United States
University of Michigan (UMICH)

Ann Arbor, Michigan, 48105, United States
University of North Texas Health Sciences Center

Fort Worth, Texas, 76107, United States
University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States
University of Pittsburgh

Pittsburgh, Pennsylvania, 15213, United States
University of Rochester

Rochester, New York, 14620, United States
University of South Florida - Health Byrd Alzheimer Institute

Tampa, Florida, 33613, United States
University of Southern California

Los Angeles, California, 90033, United States
University of Texas, Southwestern MC at Dallas

Dallas, Texas, 75390, United States
University of Washington Memory and Brain Wellness Center

Seattle, Washington, 98104, United States
University of Wisconsin

Madison, Wisconsin, 53792, United States
Vanderbilt University Medical Center

Nashville, Tennessee, 37212, United States
Wake Forest University Health Sciences

Winston-Salem, North Carolina, 27157, United States
Washington University

St Louis, Missouri, 63108, United States
Westmead Hospital

Westmead, New South Wales, Australia
Wien Center for Clinical Research

Miami Beach, Florida, 33140, United States
Yale University School of Medicine

New Haven, Connecticut, 06510, United States

Conditions

Explore the condition pages connected to this study.

EARLY PRECLINICAL ALZHEIMER'S DISEASE PRECLINICAL ALZHEIMER'S DISEASE